Volume 19, Issue 11 e202200762

Research Article

Two New Eremophilane-Type Sesquiterpenoids from Ligularia sagitta

Wan-Hong Chen

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050 P. R. China

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Hong-Ying Yang,

Hong-Ying Yang

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Yu-Xian Wang,

Yu-Xian Wang

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Mei-Lian Wen,

Mei-Lian Wen

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Zhong-Duo Yang,

Corresponding Author

Zhong-Duo Yang

[email protected]

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050 P. R. China

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Jian-Jun Chen,

Corresponding Author

Jian-Jun Chen

[email protected]

orcid.org/0000-0001-5937-5569

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Wan-Hong Chen,

Wan-Hong Chen

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050 P. R. China

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Hong-Ying Yang,

Hong-Ying Yang

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Yu-Xian Wang,

Yu-Xian Wang

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Mei-Lian Wen,

Mei-Lian Wen

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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Zhong-Duo Yang,

Corresponding Author

Zhong-Duo Yang

[email protected]

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050 P. R. China

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Jian-Jun Chen,

Corresponding Author

Jian-Jun Chen

[email protected]

orcid.org/0000-0001-5937-5569

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China

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First published: 30 September 2022

https://doi.org/10.1002/cbdv.202200762

Citations: 1

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Abstract

Two new eremophilane-type sesquiterpenoids, sagittacins F and G (1 and 2), together with one known isomer of sagittacin F (3) were isolated from the leaves and stems of Ligularia sagitta. Their structures were elucidated by interpretation of spectroscopic data and the absolute configurations of 1 and 3 were determined by X-ray spectroscopy. Compound 1 belongs to a rare class of eremophilane-type sesquiterpenoid featuring an α-oriented hydroxy group at C-1. A nitric oxide (NO) production inhibitory assay was applied to evaluate their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 2 and 3 exhibited modest NO production inhibitions with IC₅₀ values of 45.15±2.72 and 49.83±2.34 μM, respectively.

Graphical Abstract

Conflict of interest

The authors declare no conflict of interest.

Open Research

Data Availability Statement

The data that support the findings of this study are available in the supplementary material of this article.

Supporting Information

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Volume19, Issue11

November 2022

e202200762

Two New Eremophilane-Type Sesquiterpenoids from Ligularia sagitta

Abstract

Graphical Abstract

Conflict of interest

Open Research

Data Availability Statement

Supporting Information

References

Citing Literature

References

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Two New Eremophilane-Type Sesquiterpenoids from Ligularia sagitta

Abstract

Graphical Abstract

Conflict of interest

Open Research

Data Availability Statement

Supporting Information

References

Citing Literature

References

Related

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