Volume 19, Issue 11 e202200682

Research Article

Phelliribsin B: A New Styrylpyrone Derivative from the Medicinal Fungus Phellinus ribis

Wenjing Ren,

Wenjing Ren

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Wen-Jing Ren and Meng-Yu Bao contributed equally to this work.

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Mengyu Bao,

Mengyu Bao

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Wen-Jing Ren and Meng-Yu Bao contributed equally to this work.

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Jin Zhang,

Jin Zhang

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

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Yanhua Cao,

Yanhua Cao

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021 China

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Baoguo Duan,

Baoguo Duan

Sishui Siheyuan Culture and Tourism Development Company, Ltd., Sisui, 273200 China

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Lingchuan Xu,

Lingchuan Xu

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Key Laboratory of Medicinal Fungi and Resource Development in Shandong Province, Jinan, 250355 China

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Yuhong Liu,

Corresponding Author

Yuhong Liu

[email protected]

orcid.org/0000-0002-6872-6284

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Key Laboratory of Medicinal Fungi and Resource Development in Shandong Province, Jinan, 250355 China

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Wenjing Ren,

Wenjing Ren

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Wen-Jing Ren and Meng-Yu Bao contributed equally to this work.

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Mengyu Bao,

Mengyu Bao

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Wen-Jing Ren and Meng-Yu Bao contributed equally to this work.

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Jin Zhang,

Jin Zhang

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

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Yanhua Cao,

Yanhua Cao

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021 China

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Baoguo Duan,

Baoguo Duan

Sishui Siheyuan Culture and Tourism Development Company, Ltd., Sisui, 273200 China

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Lingchuan Xu,

Lingchuan Xu

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Key Laboratory of Medicinal Fungi and Resource Development in Shandong Province, Jinan, 250355 China

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Yuhong Liu,

Corresponding Author

Yuhong Liu

[email protected]

orcid.org/0000-0002-6872-6284

School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355 P. R. China

Key Laboratory of Medicinal Fungi and Resource Development in Shandong Province, Jinan, 250355 China

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First published: 08 October 2022

https://doi.org/10.1002/cbdv.202200682

Citations: 1

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Abstract

A novel styrylpyrone derivative, named phelliribsin B (1), as well as four biogenetically related known compounds, phellifuropyranone A (2), inoscavin C (3), inoscavin A (4), and inoscavin D (5) were separated and purified from the medicinal fungus Phellinus ribis. The structure of phelliribsin B was determined by spectroscopic analysis, and the absolute configuration was assigned by experimental and calculated ECD data. Additionally, the plausible biosynthetic pathway of 1 was also proposed. Compound 1 showed moderately cytotoxic activity against HepG2 and SKOV-3 tumor cell lines with IC₅₀ values of 32.71 and 57.89 μM, respectively. Based on the results of cytotoxicity against HepG2 tumor cells, the structure-activity relationship of compounds 1–4 with similar skeletons was discussed. The styrylpyrone derivatives with similar skeletons have moderately cytotoxic activity and have the potential to play an important role in the anti-tumor treatment.

Graphical Abstract

Conflict of interest

The authors declare no conflict of interest.

Open Research

Data Availability Statement

The data that support the findings of this study are available in the supplementary material of this article.

Supporting Information

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Volume19, Issue11

November 2022

e202200682

Phelliribsin B: A New Styrylpyrone Derivative from the Medicinal Fungus Phellinus ribis

Abstract

Graphical Abstract

Conflict of interest

Open Research

Data Availability Statement

Supporting Information

References

Citing Literature

References

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Phelliribsin B: A New Styrylpyrone Derivative from the Medicinal Fungus Phellinus ribis

Abstract

Graphical Abstract

Conflict of interest

Open Research

Data Availability Statement

Supporting Information

References

Citing Literature

References

Related

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