Review
Natural Compounds with Oxepinochromene Scaffold. Structure, Source, Biological Activity and Synthesis
Renata Gašparová,
Corresponding Author
Renata Gašparová
Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie J. Herdu 2, Trnava, Slovak Republic
Search for more papers by this authorRenata Gašparová,
Corresponding Author
Renata Gašparová
Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie J. Herdu 2, Trnava, Slovak Republic
Search for more papers by this authorFirst published: 13 October 2022
Abstract
Natural products containing oxepinochromene motifs were first isolated from natural sources in 1960s. Natural oxepinochromenes are relatively rare and their source is limited to several endophytic and endolichenic fungi or higher plants. The importance of natural oxepinochromene derivatives lies in their promising biological activity. They exhibit a wide range of activities such as antibacterial, anticancer, anti-inflammatory or antifungal. Consequently, their synthesis has attracted significant interest. This review discusses the source, biosynthesis, biological activity, reactions as well as the total synthesis of oxepinochromene derivatives, belonging to the xanthone, terpenoid and flavone groups of phenolic secondary metabolites.
Graphical Abstract
Conflict of interest
The authors declare no conflict of interest.
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