Volume 43, Issue 6 pp. 764-768

Communication

Benzo[g]coumarin-benzothiazole hybrid: A fluorescent probe for the detection of amyloid-beta aggregates

Na Hee Kim,

Na Hee Kim

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea

Search for more papers by this author

Youngbuhm Huh,

Corresponding Author

Youngbuhm Huh

[email protected]

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea

Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

Correspondence

Youngbuhm Huh and Dokyoung Kim, Department of Biomedical Science, Graduate School Kyung Hee University, Seoul 02447, Republic of Korea.

Email: [email protected] and [email protected]

Search for more papers by this author

Dokyoung Kim,

Corresponding Author

Dokyoung Kim

[email protected]

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea

Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

Center for Converging Humanities, Kyung Hee University, Seoul, Republic of Korea

Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, Republic of Korea

KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea

Correspondence

Youngbuhm Huh and Dokyoung Kim, Department of Biomedical Science, Graduate School Kyung Hee University, Seoul 02447, Republic of Korea.

Email: [email protected] and [email protected]

Search for more papers by this author

Na Hee Kim,

Na Hee Kim

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea

Search for more papers by this author

Youngbuhm Huh,

Corresponding Author

Youngbuhm Huh

[email protected]

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea

Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

Correspondence

Youngbuhm Huh and Dokyoung Kim, Department of Biomedical Science, Graduate School Kyung Hee University, Seoul 02447, Republic of Korea.

Email: [email protected] and [email protected]

Search for more papers by this author

Dokyoung Kim,

Corresponding Author

Dokyoung Kim

[email protected]

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea

Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

Center for Converging Humanities, Kyung Hee University, Seoul, Republic of Korea

Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, Republic of Korea

KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea

Correspondence

Youngbuhm Huh and Dokyoung Kim, Department of Biomedical Science, Graduate School Kyung Hee University, Seoul 02447, Republic of Korea.

Email: [email protected] and [email protected]

Search for more papers by this author

First published: 30 March 2022

https://doi.org/10.1002/bkcs.12525

Citations: 7

Funding information: Ministry of Health & Welfare, Republic of Korea, Grant/Award Number: HI21C0239; Korea Health Industry Development Institute; Ministry of Education, Grant/Award Number: 2018-R1A6A1A03025124; National Research Foundation

Share a link

Email
Wechat
Bluesky

Abstract

Here, we disclose a new turn-on type fluorescent probe (named BCB-1) for the detection of Aβ plaques, which is an essential biomarker in Alzheimer's disease (AD). BCB-1 has a hybrid structure of benzo[g]coumarin and benzothiazole, and it showed significant emission enhancement at the near-infrared (NIR) region when sensing Aβ plaques. BCB-1 also showed high selectivity and sensitivity toward Aβ plaques, and its bio-imaging applicability was confirmed within an AD mouse (5XFAD) brain. We expect our superb AD diagnosis fluorescent probe to be broadly applied in Aβ plaques related clinical and biological studies.

Supporting Information

REFERENCES

1O. Hansson, S. Lehmann, M. Otto, H. Zetterberg, P. Lewczuk, Alzheimer's Res. Ther. 2019, 11, 1.
10.1186/s13195-019-0485-0
CAS PubMed Web of Science® Google Scholar
2H. Lu, X.-C. Zhu, T. Jiang, J.-T. Yu, L. Tan, Ann. Transl. Med. 2015, 3, 70.
PubMed Web of Science® Google Scholar
3S. Park, Y. Yi, M. H. Lim, Bull. Korean Chem. Soc. 2021, 42, 17.
10.1002/bkcs.12172
CAS Web of Science® Google Scholar
4J. Kim, D. Kim, Bull. Korean Chem. Soc. 2022, 43, 78.
10.1002/bkcs.12433
CAS Web of Science® Google Scholar
5G. Moya-Alvarado, N. Gershoni-Emek, E. Perlson, F. C. Bronfman, Mol. Cell. Proteomics 2016, 15, 409.
10.1074/mcp.R115.053330
CAS PubMed Google Scholar
6T. Ojakaar, I. Koychev, Front. Neurol. 2021, 12, 772836.
10.3389/fneur.2021.772836
PubMed Web of Science® Google Scholar
7A. Cano, P. Turowski, M. Ettcheto, J. T. Duskey, G. Tosi, E. Sánchez-López, M. L. García, A. Camins, E. B. Souto, A. Ruiz, J. Nanobiotechnology. 2021, 19, 1.
10.1186/s12951-021-00864-x
CAS PubMed Web of Science® Google Scholar
8C. Ross, M. Taylor, N. Fullwood, D. Allsop, Int. J. Nanomed. 2018, 13, 8507.
10.2147/IJN.S183117
CAS PubMed Web of Science® Google Scholar
9A. D. Cohen, G. D. Rabinovici, C. A. Mathis, W. J. Jagust, W. E. Klunk, M. D. Ikonomovic, Adv. Pharmacol. 2012, 64, 27.
10.1016/B978-0-12-394816-8.00002-7
CAS PubMed Web of Science® Google Scholar
10S. Landau, B. Thomas, L. Thurfjell, M. Schmidt, R. Margolin, M. Mintun, M. Pontecorvo, S. Baker, W. Jagust, Eur. J. Nucl. Med. Mol. Imaging 2014, 41, 1398.
10.1007/s00259-014-2753-3
CAS PubMed Web of Science® Google Scholar
11C. Mathis, N. S. Mason, B. Lopresti, W. Klunk, Semin. Nucl. Med. 2012, 42, 423.
10.1053/j.semnuclmed.2012.07.001
PubMed Web of Science® Google Scholar
12Z. Guo, C. Yan, W. H. Zhu, Angew. Chem., Int. Ed. 2020, 59, 9812.
10.1002/anie.201913249
CAS PubMed Web of Science® Google Scholar
13A. A. Reinke, J. E. Gestwicki, Chem. Biol. Drug Des. 2011, 77, 399.
10.1111/j.1747-0285.2011.01110.x
CAS PubMed Web of Science® Google Scholar
14H. Wu, Z. Liu, Y. Shao, G. Li, Y. Pan, L. Wang, E. U. Akkaya, Chem. Commun. 2022, 58, 3747.
10.1039/D1CC07133E
CAS PubMed Web of Science® Google Scholar
15N. Karton-Lifshin, L. Albertazzi, M. Bendikov, P. S. Baran, D. Shabat, J. Am. Chem. Soc. 2012, 134, 20412.
10.1021/ja308124q
CAS PubMed Web of Science® Google Scholar
16S. Singha, D. Kim, B. Roy, S. Sambasivan, H. Moon, A. S. Rao, J. Y. Kim, T. Joo, J. W. Park, Y. M. Rhee, Chem. Sci. 2015, 6, 4335.
10.1039/C5SC01076D
CAS PubMed Web of Science® Google Scholar
17X. Tian, L. C. Murfin, L. Wu, S. E. Lewis, T. D. James, Chem. Sci. 2021, 12, 3406.
10.1039/D0SC06928K
CAS PubMed Web of Science® Google Scholar
18Y. Jung, J. Jung, Y. Huh, D. Kim, J. Anal. Methods Chem. 2018, 2018, 5249765.
10.1155/2018/5249765
PubMed Web of Science® Google Scholar
19S. Sarkar, M. Santra, S. Singha, Y. W. Jun, Y. J. Reo, H. R. Kim, K. H. Ahn, J. Mater. Chem. B 2018, 6, 4446.
10.1039/C8TB01144C
CAS PubMed Web of Science® Google Scholar
20D. Kim, H. Moon, S. H. Baik, S. Singha, Y. W. Jun, T. Wang, K. H. Kim, B. S. Park, J. Jung, I. Mook-Jung, J. Am. Chem. Soc. 2015, 137, 6781.
10.1021/jacs.5b03548
CAS PubMed Web of Science® Google Scholar
21D. Kim, S. H. Baik, S. Kang, S. W. Cho, J. Bae, M.-Y. Cha, M. J. Sailor, I. Mook-Jung, K. H. Ahn, ACS Cent. Sci. 2016, 2, 967.
10.1021/acscentsci.6b00309
CAS PubMed Web of Science® Google Scholar
22J. Shin, P. Verwilst, H. Choi, S. Kang, J. Han, N. H. Kim, J. G. Choi, M. S. Oh, J. S. Hwang, D. Kim, Angew. Chem., Int. Ed. 2019, 58, 5648.
10.1002/anie.201900549
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume43, Issue6

June 2022

Pages 764-768

This article also appears in:

Emerging Investigators

Benzo[g]coumarin-benzothiazole hybrid: A fluorescent probe for the detection of amyloid-beta aggregates

Abstract

Supporting Information

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Benzo[g]coumarin-benzothiazole hybrid: A fluorescent probe for the detection of amyloid-beta aggregates

Abstract

Supporting Information

REFERENCES

Citing Literature

References

Related

Information