Atypical development of the central auditory system in young children with Autism spectrum disorder
Yuko Yoshimura
Institute of Human and Social Sciences, Kanazawa University, Kanazawa, 920-1192 Japan
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorCorresponding Author
Mitsuru Kikuchi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640 Japan
Address for correspondence and reprints: Mitsuru Kikuchi, Research Center for child Mental Development, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan. E-mail: [email protected]Search for more papers by this authorHirotoshi Hiraishi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorChiaki Hasegawa
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorTetsuya Takahashi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorGerard B. Remijn
International Education Center, Kyushu University, Fukuoka, 815-8540 Japan
Search for more papers by this authorManabu Oi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorToshio Munesue
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorHaruhiro Higashida
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorYoshio Minabe
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorHaruyuki Kojima
Institute of Human and Social Sciences, Kanazawa University, Kanazawa, 920-1192 Japan
Search for more papers by this authorYuko Yoshimura
Institute of Human and Social Sciences, Kanazawa University, Kanazawa, 920-1192 Japan
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorCorresponding Author
Mitsuru Kikuchi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640 Japan
Address for correspondence and reprints: Mitsuru Kikuchi, Research Center for child Mental Development, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan. E-mail: [email protected]Search for more papers by this authorHirotoshi Hiraishi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorChiaki Hasegawa
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorTetsuya Takahashi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorGerard B. Remijn
International Education Center, Kyushu University, Fukuoka, 815-8540 Japan
Search for more papers by this authorManabu Oi
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorToshio Munesue
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorHaruhiro Higashida
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorYoshio Minabe
Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640 Japan
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 920-8640 Japan
Search for more papers by this authorHaruyuki Kojima
Institute of Human and Social Sciences, Kanazawa University, Kanazawa, 920-1192 Japan
Search for more papers by this authorAbstract
The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32–121 months of age) and 35 children with autism spectrum disorder (ASD) (38–111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. Autism Res 2016, 9: 1216–1226. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
Supporting Information
| Filename | Description |
|---|---|
| aur1604-sup-0001-supptables.doc148 KB |
Table S1. Age of the participants in previous quantitative MEG studies of children with ASD. Table S2. Hierarchical regression analysis summery for P1m latency on age and mental processing scale in TD children. Table S3. Hierarchical regression analysis summery for P1m latency on age and verbal ability in TD children. Table S4. Hierarchical regression analysis summery for P1m latency on age and mental processing scale in ASD children. Table S5. Hierarchical regression analysis summery for P1m latency on age and verbal ability in ASD children. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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