Fibrous-biocomposites scaffold of natural rubber with bioactive glass–ceramic particles obtained by solution blowing spinning
Luiz Rogério Monteiro Lima
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Validation (equal), Writing - original draft (equal)
Search for more papers by this authorJosé Luiz Vilches
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Writing - original draft (equal)
Search for more papers by this authorGuilherme Ferreira Caetano
Graduate Program in Biomedical Sciences, University Center of Hermínio Ometto Foundation, FHO, Araras, São Paulo, Brazil
Division of Dermatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorLais Dantas Silva
Postgraduate Program in Materials Engineering, Federal Institute of Maranhão - IFMA, São Luis, Brazil
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorViviane Oliveira Soares
Department of Sciences, Regional Campus of Goioerê, State University of Maringá (UEM), Goioerê, Paraná, Brazil
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorRenivaldo José dos Santos
Department of Engineering, School of Engineering and Science, São Paulo State University (UNESP), Rosana, São Paulo, Brazil
Contribution: Data curation (supporting), Formal analysis (supporting), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorAlex Otávio Sanches
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorJosé Antônio Malmonge
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Conceptualization (equal), Formal analysis (equal), Methodology (equal), Supervision (equal), Validation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Alexander L. Yarin
Department of Mechanical and Industrial Engineering, University of Illinois at Chicago (UIC), Chicago, Illinois, USA
Correspondence
Alexander L. Yarin, University of Illinois at Chicago (UIC), Department of Mechanical and Industrial Engineering, 842 W. Taylor St, Chicago, Illinois 60607-7022, USA.
Email: [email protected]
Michael Jones Silva, São Paulo State University (UNESP), School of Engineering and Science, Department of Energy Engineering, Rosana, São Paulo 19274-000, Brazil.
Email: [email protected]
Contribution: Supervision (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Michael Jones Silva
Department of Engineering, School of Engineering and Science, São Paulo State University (UNESP), Rosana, São Paulo, Brazil
Correspondence
Alexander L. Yarin, University of Illinois at Chicago (UIC), Department of Mechanical and Industrial Engineering, 842 W. Taylor St, Chicago, Illinois 60607-7022, USA.
Email: [email protected]
Michael Jones Silva, São Paulo State University (UNESP), School of Engineering and Science, Department of Energy Engineering, Rosana, São Paulo 19274-000, Brazil.
Email: [email protected]
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Funding acquisition (equal), Investigation (equal), Methodology (equal), Project administration (lead), Resources (lead), Supervision (lead), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorLuiz Rogério Monteiro Lima
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Validation (equal), Writing - original draft (equal)
Search for more papers by this authorJosé Luiz Vilches
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Writing - original draft (equal)
Search for more papers by this authorGuilherme Ferreira Caetano
Graduate Program in Biomedical Sciences, University Center of Hermínio Ometto Foundation, FHO, Araras, São Paulo, Brazil
Division of Dermatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorLais Dantas Silva
Postgraduate Program in Materials Engineering, Federal Institute of Maranhão - IFMA, São Luis, Brazil
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorViviane Oliveira Soares
Department of Sciences, Regional Campus of Goioerê, State University of Maringá (UEM), Goioerê, Paraná, Brazil
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorRenivaldo José dos Santos
Department of Engineering, School of Engineering and Science, São Paulo State University (UNESP), Rosana, São Paulo, Brazil
Contribution: Data curation (supporting), Formal analysis (supporting), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorAlex Otávio Sanches
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (equal), Writing - original draft (equal)
Search for more papers by this authorJosé Antônio Malmonge
Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil
Contribution: Conceptualization (equal), Formal analysis (equal), Methodology (equal), Supervision (equal), Validation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Alexander L. Yarin
Department of Mechanical and Industrial Engineering, University of Illinois at Chicago (UIC), Chicago, Illinois, USA
Correspondence
Alexander L. Yarin, University of Illinois at Chicago (UIC), Department of Mechanical and Industrial Engineering, 842 W. Taylor St, Chicago, Illinois 60607-7022, USA.
Email: [email protected]
Michael Jones Silva, São Paulo State University (UNESP), School of Engineering and Science, Department of Energy Engineering, Rosana, São Paulo 19274-000, Brazil.
Email: [email protected]
Contribution: Supervision (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Michael Jones Silva
Department of Engineering, School of Engineering and Science, São Paulo State University (UNESP), Rosana, São Paulo, Brazil
Correspondence
Alexander L. Yarin, University of Illinois at Chicago (UIC), Department of Mechanical and Industrial Engineering, 842 W. Taylor St, Chicago, Illinois 60607-7022, USA.
Email: [email protected]
Michael Jones Silva, São Paulo State University (UNESP), School of Engineering and Science, Department of Energy Engineering, Rosana, São Paulo 19274-000, Brazil.
Email: [email protected]
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Funding acquisition (equal), Investigation (equal), Methodology (equal), Project administration (lead), Resources (lead), Supervision (lead), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this author[Correction added on January 13, 2025, after first online publication: Lais Dantas Silva author has been included in the author group as fourth author]
Abstract
Bioactive glass-ceramics (BGs) are widely used in clinical applications due to their excellent biodynamic and biological properties, though their low mechanical strength limits their use in load-bearing contexts. This study aimed to develop fibrous biocomposite scaffolds based on natural rubber (NR) reinforced with BG particles, such as biosilicato (BioS) and 45S5-K (BL0), to improve tensile strength, biocompatibility, and bioactivity for biomedical applications, such as tissue engineering. Morphological, tensile, thermal, and biological tests were conducted to evaluate the impact of BG particles on the NR fibrous matrix. TG/DTG analysis revealed similar decomposition profiles for NR/BioS and NR/BL0 biocomposites compared to NR mats, with primary degradation occurring in the 290–450°C range. Tensile tests demonstrated that the addition of 30 mass% BioS or BL0 enhanced the ultimate tensile strength (σbreak) of the NR matrix from 1.44 ± 0.08 to 3.38 ± 1.31 MPa (NR/BioS) and 1.97 ± 0.53 MPa (NR/BL0). The Cole–Cole plot indicated system heterogeneity and strong NR-BG particle interactions. Cytotoxicity tests revealed over 70% MSC viability for NR, NR/BioS, and NR/BL0 biocomposites, meeting ISO 10993-5:2009 standards. These findings suggest that incorporating BioS and BL0 enhances the mechanical and biological properties of NR-based scaffolds, making them suitable for biomedical applications, such as bone regeneration.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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