Electrospun poly(L-lactide)/poly(ε-caprolactone) blend fibers and their cellular response to adipose-derived stem cells
Gui-Ying Liao
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorLiang Chen
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorCorresponding Author
Xiao-Yong Zeng
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Xiao-Yong Zeng, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Xiao-Lin Xie, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Search for more papers by this authorXing-Ping Zhou
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorCorresponding Author
Xiao-Lin Xie
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Xiao-Yong Zeng, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Xiao-Lin Xie, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Search for more papers by this authorE-Jun Peng
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorZhang-Qun Ye
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorYiu-Wing Mai
Center for Advanced Materials Technology (CAMT), School of Aerospace, Mechanical and Mechatronic Engineering J07, University of Sydney, Sydney, New South Wales, Australia
Search for more papers by this authorGui-Ying Liao
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorLiang Chen
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorCorresponding Author
Xiao-Yong Zeng
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Xiao-Yong Zeng, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Xiao-Lin Xie, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Search for more papers by this authorXing-Ping Zhou
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorCorresponding Author
Xiao-Lin Xie
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Xiao-Yong Zeng, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Xiao-Lin Xie, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China===
Search for more papers by this authorE-Jun Peng
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorZhang-Qun Ye
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Search for more papers by this authorYiu-Wing Mai
Center for Advanced Materials Technology (CAMT), School of Aerospace, Mechanical and Mechatronic Engineering J07, University of Sydney, Sydney, New South Wales, Australia
Search for more papers by this authorAbstract
Polymer blending is one of the most effective methods for providing new, desirable biocomposites for tissue-engineering applications. In this study, electrospun poly(L-lactide)/poly(ε-caprolactone) (PLLA/PCL) blend fibrous membranes with defect-free morphology and uniform diameter were optimally prepared by a 1 : 1 ratio of PLLA/PCL blend under a solution concentration of 10 wt %, an applied voltage of 20 kV, and a tip-to-collector distance of 15 cm. The fibrous membranes also showed a porous structure and high ductility. Because of the rapid solidification of polymer solution during electrospinning, the crystallinity of electrospun PLLA/PCL blend fibers was much lower than that of the PLLA/PCL blend cast film. To obtain an initial understanding of biocompatibility, adipose-derived stem cells (ADSCs) were used as seed cells to assess the cellular response, including morphology, proliferation, viability, attachment, and multilineage differentiation on the PLLA/PCL blend fibrous scaffold. Because of the good biocompatibility and nontoxic effect on ADSCs, the PLLA/PCL blend electrospun fibrous membrane provided a high-performance scaffold for feasible application in tissue engineering using ADSCs. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
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