Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand
Hui Liu
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China
Search for more papers by this authorYing-ying Kou
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Search for more papers by this authorLi Feng
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, People's Republic of China
Search for more papers by this authorDong-dong Li
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Search for more papers by this authorChun-Yan Gao
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Search for more papers by this authorCorresponding Author
Jin-lei Tian
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.Search for more papers by this authorJing-yan Zhang
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China
Search for more papers by this authorCorresponding Author
Shi-ping Yan
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.Search for more papers by this authorHui Liu
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China
Search for more papers by this authorYing-ying Kou
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Search for more papers by this authorLi Feng
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, People's Republic of China
Search for more papers by this authorDong-dong Li
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Search for more papers by this authorChun-Yan Gao
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Search for more papers by this authorCorresponding Author
Jin-lei Tian
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.Search for more papers by this authorJing-yan Zhang
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China
Search for more papers by this authorCorresponding Author
Shi-ping Yan
Department of Chenistry, Nankai University, Tianjin, 300071, People's Republic of China
Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.Search for more papers by this authorAbstract
Two new mononuclear iron(III) complexes, [Fe(HL)2](ClO4) · (H2O)1.75· CH3CN (1) and [Fe(HL)Cl2] · DMF (2) [H2L = 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole] have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers. Copyright © 2010 John Wiley & Sons, Ltd.
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