Communication
Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition
Ke Xu,
Wenchang Li,
Shaoheng Zhu,
Prof. Dr. Tingshun Zhu,
Ke Xu
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorWenchang Li
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorShaoheng Zhu
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Tingshun Zhu
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorKe Xu,
Wenchang Li,
Shaoheng Zhu,
Prof. Dr. Tingshun Zhu,
Ke Xu
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorWenchang Li
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorShaoheng Zhu
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Tingshun Zhu
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 China
Search for more papers by this authorGraphical Abstract
Atroposelective [4+2]: A new organocatalyzed atroposelective arene formation reaction involves a carbene-catalyzed formal [4+2] cycloaddition of conjugated enals and α-aryl ketones. This study expands the synthetic potential of N-heterocyclic carbene (NHC) organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.
Abstract
Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.
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