Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation
Satyajit Roy
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
These authors contributed equally to this work.
Search for more papers by this authorHillol Khatua
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
These authors contributed equally to this work.
Search for more papers by this authorSandip Kumar Das
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
Search for more papers by this authorCorresponding Author
Prof. Dr. Buddhadeb Chattopadhyay
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
Search for more papers by this authorSatyajit Roy
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
These authors contributed equally to this work.
Search for more papers by this authorHillol Khatua
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
These authors contributed equally to this work.
Search for more papers by this authorSandip Kumar Das
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
Search for more papers by this authorCorresponding Author
Prof. Dr. Buddhadeb Chattopadhyay
Division of Molecular Synthesis & Drug Discovery, Centre of Bio-Medical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow, 226014 U.P., India
Search for more papers by this authorGraphical Abstract
1,2,3,4: A unique intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by employing a catalytic amount of Fe(TPP)Cl and Zn dust. This reaction precludes the traditional click reaction between organic azides and alkynes.
Abstract
A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.
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