Minireview
Assemblies of Peptides in a Complex Environment and their Applications
Dr. Huaimin Wang,
Zhaoqianqi Feng,
Prof. Dr. Bing Xu,
Dr. Huaimin Wang
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454 USA
Search for more papers by this authorZhaoqianqi Feng
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454 USA
Search for more papers by this authorCorresponding Author
Prof. Dr. Bing Xu
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454 USA
Search for more papers by this authorDr. Huaimin Wang,
Zhaoqianqi Feng,
Prof. Dr. Bing Xu,
Dr. Huaimin Wang
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454 USA
Search for more papers by this authorZhaoqianqi Feng
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454 USA
Search for more papers by this authorCorresponding Author
Prof. Dr. Bing Xu
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454 USA
Search for more papers by this authorGraphical Abstract
The rational design of peptide assemblies to achieve complex functions in a cellular environment has attracted increasing attention in recent years. In this Minireview, selected examples of peptide assemblies are highlighted, with a focus on instructed assembly for the spatiotemporal control of peptide assemblies in cells.
Abstract
Using peptide assemblies with emergent properties to achieve elaborate functions has attracted increasing attention in recent years. Besides tailoring the self-assembly of peptides in vitro, peptide research is advancing into a new and exciting frontier: the rational design of peptide assemblies (or their derivatives) for biological functions in a complex environment. This Minireview highlights recent developments in peptide assemblies and their applications in biological systems. After introducing the unique merits of peptide assemblies, we discuss the recent progress in designing peptides (or peptide derivatives) for self-assembly with conformational control. Then, we describe biological functions of peptide assemblies, with an emphasis on approach-instructed assembly for spatiotemporal control of peptide assemblies, in the cellular context. Finally, we discuss the future promises and challenges of this exciting area of chemistry.
Conflict of interest
The authors declare no conflict of interest.
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