The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics
Lu An
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
These authors contributed equally to this work.
Search for more papers by this authorXiaodong Wang
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
These authors contributed equally to this work.
Search for more papers by this authorXichuan Rui
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorDr. Jiaomin Lin
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorProf. Hong Yang
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorCorresponding Author
Prof. Qiwei Tian
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorCheng Tao
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorCorresponding Author
Prof. Shiping Yang
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorLu An
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
These authors contributed equally to this work.
Search for more papers by this authorXiaodong Wang
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
These authors contributed equally to this work.
Search for more papers by this authorXichuan Rui
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorDr. Jiaomin Lin
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorProf. Hong Yang
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorCorresponding Author
Prof. Qiwei Tian
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorCheng Tao
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorCorresponding Author
Prof. Shiping Yang
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234 China
Search for more papers by this authorGraphical Abstract
A turn-on theranostics agent was developed by utilizing the in situ reaction of Cu2O (see picture: brown) and endogenous H2S (yellow) at colon tumor sites. Based on in vitro and in vivo experiments, excellent photoacoustic imaging and photothermal therapy were both confirmed after being triggered by this in situ reaction. Cu9S8 shown in green.
Abstract
Expression of a high concentration of H2S is closely related to the formation of colon cancer tumors. However, only a few H2S-triggered theranostics agents for colon cancer have been reported to date. Now, a turn-on theranostics agent was developed by utilizing the in situ reaction of Cu2O and endogenous H2S at colon tumor sites. Based on in vitro and in vivo experiments, excellent photoacoustic imaging and photothermal therapy were both confirmed by this in situ reaction-activated colon cancer theranostics method. This work established a simple and efficient strategy for both diagnosis and treatment of colon cancer with a novel trigger mechanism, which provides a new route for colon cancer theranostics based on the in situ reactions at the tumor sites.
Supporting Information
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
| Filename | Description |
|---|---|
| anie201810082-sup-0001-misc_information.pdf1.8 MB | Supplementary |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1
- 1aR. L. Siegel, K. D. Miller, S. A. Fedewa, D. J. Ahnen, R. G. S. Meester, A. Barzi, A. Jemal, CA Cancer J. Clin. 2017, 67, 177–193;
- 1bL. Ricci-Vitiani, D. G. Lombardi, E. Pilozzi, M. Biffoni, M. Todaro, C. Peschle, R. De Maria, Nature 2006, 445, 111–115.
- 2
- 2aC. Hassan, A. Repici, Am. J. Roentgenol. 2017, 209, 88–93;
- 2bY. Zhang, Z. Chen, J. Li, Medicine 2017, 96, e 8242.
- 3K. Kashfi, Biochem. Pharmacol. 2018, 149, 1–4.
- 4
- 4aC. Szabo, C. Coletta, C. Chao, K. Módis, B. Szczesny, A. Papapetropoulos, M. R. Hellmich, Proc. Natl. Acad. Sci. USA 2013, 110, 12474–12479;
- 4bM. R. Hellmich, C. Szabo, Handb. Exp. Pharmacol. 2015, 230, 233–241;
- 4cY. C. Wu, X. J. Wang, L. Yu, F. K. L. Chan, A. S. L. Cheng, J. Yu, J. J. Y. Sung, W. K. K. Wu, C. H. Cho, PLoS One 2012, 7, e 37572;
- 4dY. Chen, C. Zhu, Z. Yang, J. Chen, Y. He, Y. Jiao, W. He, L. Qiu, J. Cen, Z. Guo, Angew. Chem. Int. Ed. 2013, 52, 1688–1691; Angew. Chem. 2013, 125, 1732–1735.
- 5C. Szabó, Nat. Rev. Drug Discovery 2007, 6, 917–935.
- 6X. Cao, L. Ding, Z.-z. Xie, Y. Yang, M. Whiteman, P. K. Moore, J.-S. Bian, Antioxid. Redox. Sign. 2018, https://doi.org/10.1089/ars.2017.7058.
- 7
- 7aW. Xuan, C. Sheng, Y. Cao, W. He, W. Wang, Angew. Chem. Int. Ed. 2012, 51, 2282–2284; Angew. Chem. 2012, 124, 2328–2330;
- 7bM. D. Hartle, M. D. Pluth, Chem. Soc. Rev. 2016, 45, 6108–6117;
- 7cV. S. Lin, W. Chen, M. Xian, C. J. Chang, Chem. Soc. Rev. 2015, 44, 4596–4618.
- 8
- 8aC. Zhao, X. Zhang, K. Li, S. Zhu, Z. Guo, L. Zhang, F. Wang, Q. Fei, S. Luo, P. Shi, H. Tian, W.-H. Zhu, J. Am. Chem. Soc. 2015, 137, 8490–8498;
- 8bS. Chen, Z.-j. Chen, W. Ren, H.-w. Ai, J. Am. Chem. Soc. 2012, 134, 9589–9592.
- 9
- 9aB. Shi, X. Gu, Q. Fei, C. Zhao, Chem. Sci. 2017, 8, 2150–2155;
- 9bG. Xu, Q. Yan, X. Lv, Y. Zhu, K. Xin, B. Shi, R. Wang, J. Chen, W. Gao, P. Shi, C. Fan, C. Zhao, H. Tian, Angew. Chem. Int. Ed. 2018, 57, 3626–3630; Angew. Chem. 2018, 130, 3688–3692;
- 9cJ. Cao, R. Lopez, J. M. Thacker, J. Y. Moon, C. Jiang, S. N. S. Morris, J. H. Bauer, P. Tao, R. P. Mason, A. R. Lippert, Chem. Sci. 2015, 6, 1979–1985;
- 9dK. Zhang, J. Zhang, Z. Xi, L.-Y. Li, X. Gu, Q.-Z. Zhang, L. Yi, Chem. Sci. 2017, 8, 2776–2781.
- 10Y. Ma, X. Li, A. Li, P. Yang, C. Zhang, B. Tang, Angew. Chem. Int. Ed. 2017, 56, 13752–13756; Angew. Chem. 2017, 129, 13940–13944.
- 11D.-F. Zhang, H. Zhang, Y. Shang, L. Guo, Cryst. Growth Des. 2011, 11, 3748–3753.
- 12D. Gao, Z. Sheng, Y. Liu, D. Hu, J. Zhang, X. Zhang, H. Zheng, Z. Yuan, Adv. Healthcare Mater. 2017, 6, 1601094.
- 13Y. Wang, Y. Wu, Y. Liu, J. Shen, L. Lv, L. Li, L. Yang, J. Zeng, Y. Wang, L. W. Zhang, Z. Li, M. Gao, Z. Chai, Adv. Funct. Mater. 2016, 26, 5335–5344.
- 14D. Ni, D. Jiang, H. F. Valdovinos, E. B. Ehlerding, B. Yu, T. E. Barnhart, P. Huang, W. Cai, Nano Lett. 2017, 17, 3282–3289.
- 15Q. Tian, F. Jiang, R. Zou, Q. Liu, Z. Chen, M. Zhu, S. Yang, J. Wang, J. Wang, J. Hu, ACS Nano 2011, 5, 9761–9771.
