Biocatalytic Feedback-Driven Temporal Programming of Self-Regulating Peptide Hydrogels
Thomas Heuser
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.de
Search for more papers by this authorElisabeth Weyandt
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.de
Search for more papers by this authorCorresponding Author
Dr. Andreas Walther
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.de
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.deSearch for more papers by this authorThomas Heuser
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.de
Search for more papers by this authorElisabeth Weyandt
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.de
Search for more papers by this authorCorresponding Author
Dr. Andreas Walther
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.de
DWI—Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen (Germany) http://www.dwi.rwth-aachen.deSearch for more papers by this authorGraphical Abstract
Programmed to self-destruct: An internal enzymatic feedback system enables the autonomous self-regulation over time of a pH-responsive peptide gelator (see picture; SA=self-assembly). The resulting dynamic hydrogels with programmed lifetimes are suitable for application in fluidic guidance, burst release, and transient rapid prototyping.
Abstract
Switchable self-assemblies respond to external stimuli with a transition between near-equilibrium states. Although being a key to present-day advanced materials, these systems respond rather passively, and do not display autonomous dynamics. For autonomous behavior, approaches must be found to orchestrate the time domain of self-assemblies, which would lead to new generations of dynamic and self-regulating materials. Herein, we demonstrate catalytic control of the time domain of pH-responsive peptide hydrogelators in a closed system. We program transient acidic pH states by combining a fast acidic activator with the slow, enzymatic, feedback-driven generation of a base (dormant deactivator). This transient state can be programmed over orders of magnitude in time. It is coupled to dipeptides to create autonomously self-regulating, dynamic gels with programmed lifetimes, which are used for fluidic guidance, burst release, and self-erasing rapid prototyping.
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| Filename | Description |
|---|---|
| anie_201505013_sm_MovieS1.mp44.7 MB | MovieS1 |
| anie_201505013_sm_MovieS2.mp45.8 MB | MovieS2 |
| anie_201505013_sm_miscellaneous_information.pdf950 KB | miscellaneous_information |
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