Communication
Palladium-Catalyzed Enantioselective CH Arylation for the Synthesis of P-Stereogenic Compounds†
Zi-Qi Lin,
Wei-Zhen Wang,
Shao-Bai Yan,
Prof. Dr. Wei-Liang Duan,
Zi-Qi Lin
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
Search for more papers by this authorWei-Zhen Wang
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
Search for more papers by this authorShao-Bai Yan
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Wei-Liang Duan
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)Search for more papers by this authorZi-Qi Lin,
Wei-Zhen Wang,
Shao-Bai Yan,
Prof. Dr. Wei-Liang Duan,
Zi-Qi Lin
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
Search for more papers by this authorWei-Zhen Wang
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
Search for more papers by this authorShao-Bai Yan
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Wei-Liang Duan
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)Search for more papers by this author†
This work was financially supported by the National Basic Research Program of China (973 Program 2010CB833300) and NSFC (20902099, 21172238, and 21472218).
Graphical Abstract
Dressing up phosphorus: The title reaction of N-(o-bromoaryl)-diarylphosphinic amides is described for the synthesis of phosphorus compounds bearing a P-stereogenic center. The method provides good enantioselectivities and high yields. The products were readily transformed into P-chiral biphenyl monophosphine ligands.
Abstract
A palladium-catalyzed enantioselective CH arylation of N-(o-bromoaryl)-diarylphosphinic amides is described for the synthesis of phosphorus compounds bearing a P-stereogenic center. The method provides good enantioselectivities and high yields. The products were readily transformed into P-chiral biphenyl monophosphine ligands.
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