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Free Access
Inside Back Cover: An Unusual Protein–Protein Interaction through Coupled Unfolding and Binding (Angew. Chem. Int. Ed. 37/2014)
First published: 07 July 2014
Graphical Abstract
Protein–protein interactions can involve the folding of a disordered region to form the binding interface. In their Communication on page 9784 ff., J. Y. Suh and co-workers report the opposite case, in which binding is accompanied by local unfolding. The structure of an engineered peptide bound to fibronectin extradomain B reveals coupled unfolding and binding through β-strand displacement. The unfolding exposes a hydrophobic surface that provides key interactions for the complex.
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