Catching Bubbles: Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse-Electron-Demand Diels–Alder Reactions†
Aimen Zlitni
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorNancy Janzen
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorDr. F. Stuart Foster
Department of Medical Biophysics, University of Toronto, Sunnybrook Hospital, Toronto, Ont. M4N S658 (Canada)
Search for more papers by this authorCorresponding Author
Dr. John F. Valliant
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)Search for more papers by this authorAimen Zlitni
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorNancy Janzen
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Search for more papers by this authorDr. F. Stuart Foster
Department of Medical Biophysics, University of Toronto, Sunnybrook Hospital, Toronto, Ont. M4N S658 (Canada)
Search for more papers by this authorCorresponding Author
Dr. John F. Valliant
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)
Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, Ont., L8S 4M1 (Canada)Search for more papers by this authorFinancial support for this research was provided by the Natural Sciences and Engineering Research Council (NSERC) of Canada, The Ontario Ministry of Research and Innovation, the Ontario Research Fund (grant no. RE03-051), and the Canadian Cancer Society (grant no. 2011-700896). The authors also acknowledge Frederick R. Roberts and VisualSonics for their technical support.
Graphical Abstract
Catching bubbles: Tetrazine-functionalized microbubbles were prepared for use as ultrasound contrast agents, and shown to selectively localize on cells labeled with a TCO-derivatized antibody against VEGFR2. This capture approach based on labeling and bioorthogonal chemistry was validated in a flow-chamber assay and in vivo through ultrasound imaging of VEGFR2-positive and VEGFR2-negative murine tumor models. TCO=trans-cyclooctene.
Supporting Information
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| Filename | Description |
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| anie_201402473_sm_miscellaneous_information.pdf6 MB | miscellaneous_information |
| anie_201402473_sm_with-no-tco-antibody.mp429.5 MB | with-no-tco-antibody |
| anie_201402473_sm_with-tco-antibody.mp436.5 MB | with-tco-antibody |
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