Communication
ChenPhos: Highly Modular P-Stereogenic C1-Symmetric Diphosphine Ligands for the Efficient Asymmetric Hydrogenation of α-Substituted Cinnamic Acids
Dr. Weiping Chen,
Dr. Felix Spindler,
Dr. Benoit Pugin,
Dr. Ulrike Nettekoven,
Corresponding Author
Dr. Weiping Chen
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Present address: School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032 (P. R. China)
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)Search for more papers by this authorDr. Felix Spindler
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Search for more papers by this authorDr. Benoit Pugin
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Search for more papers by this authorDr. Ulrike Nettekoven
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Search for more papers by this authorDr. Weiping Chen,
Dr. Felix Spindler,
Dr. Benoit Pugin,
Dr. Ulrike Nettekoven,
Corresponding Author
Dr. Weiping Chen
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Present address: School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032 (P. R. China)
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)Search for more papers by this authorDr. Felix Spindler
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Search for more papers by this authorDr. Benoit Pugin
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Search for more papers by this authorDr. Ulrike Nettekoven
Solvias AG, WRO-1055.6.68B, Mattenstrasse 22, Postfach, 4002 Basel (Switzerland)
Search for more papers by this authorGraphical Abstract
These cats are purrfectionists: The ChenPhos ligands (see structure) showed dramatically higher catalytic activity in the title reaction than their C2-symmetric predecessor with two dimethylaminoethyl-substituted ferrocenyl(phenyl)phosphanyl groups. The ready accessibility, extreme air stability, and high enantioselectivity, activity, and productivity of these ligands make them very promising for a wide range of practical applications.
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