Communication
Synchronous ArF and ArSn Bond Formation through Fluorostannylation of Arynes†
Prof. Dr. Hiroto Yoshida,
Ryuma Yoshida,
Prof. Dr. Ken Takaki,
Corresponding Author
Prof. Dr. Hiroto Yoshida
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)Search for more papers by this authorRyuma Yoshida
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)
Search for more papers by this authorProf. Dr. Ken Takaki
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)
Search for more papers by this authorProf. Dr. Hiroto Yoshida,
Ryuma Yoshida,
Prof. Dr. Ken Takaki,
Corresponding Author
Prof. Dr. Hiroto Yoshida
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)Search for more papers by this authorRyuma Yoshida
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)
Search for more papers by this authorProf. Dr. Ken Takaki
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan)
Search for more papers by this author†
We thank Central Glass Co. Ltd. for a generous gift of trifluoromethanesulfonic anhydride.
Graphical Abstract
An aryne insertion into the FSn bond of tributyltin fluoride leads to the synchronous formation of ArF and ArSn bonds to afford diverse 2-fluoroarylstannanes straightforwardly. The formal total synthesis of flurbiprofen by using a fluorostannylation product is also reported.
Supporting Information
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