Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit†
Tomohiro Doura
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
Search for more papers by this authorRyunosuke Hata
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
Search for more papers by this authorDr. Hiroshi Nonaka
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
Search for more papers by this authorProf. Kazuhiro Ichikawa
Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka (Japan)
Search for more papers by this authorCorresponding Author
Prof. Shinsuke Sando
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)Search for more papers by this authorTomohiro Doura
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
Search for more papers by this authorRyunosuke Hata
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
Search for more papers by this authorDr. Hiroshi Nonaka
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
Search for more papers by this authorProf. Kazuhiro Ichikawa
Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka (Japan)
Search for more papers by this authorCorresponding Author
Prof. Shinsuke Sando
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)
INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka (Japan)Search for more papers by this authorThis work was supported by the NEXT Program and partly by Grant-in-Aid number 22685018 from JSPS. We thank Mr. T. Abe of Oxford Instruments for helpful discussion and technical assistance on the DNP experiments.
Graphical Abstract
How to live longer: A fully deuterated 13C methoxy group (13CD3O) is presented as a new long-lived hyperpolarization unit for designing a sensitive 13C magnetic resonance probe. By utilizing the unit, a hyperpolarized magnetic resonance probe for sensing hypochlorous acid was successfully designed.
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