CH⋅⋅⋅O Hydrogen Bonding Induced Triazole Foldamers: Efficient Halogen Bonding Receptors for Organohalogens†
Dr. Li-Yan You
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
These authors contributed equally to this project.
Search for more papers by this authorDr. Shi-Gui Chen
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
These authors contributed equally to this project.
Search for more papers by this authorCorresponding Author
Prof. Xin Zhao
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)Search for more papers by this authorProf. Yi Liu
The Molecular Foundry, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720 (USA)
Search for more papers by this authorDr. Wen-Xian Lan
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
Search for more papers by this authorYing Zhang
Chemistry of Department, Fudan University, 220 Handan Road, Shanghai 200433 (China)
Search for more papers by this authorProf. Hao-Jie Lu
Chemistry of Department, Fudan University, 220 Handan Road, Shanghai 200433 (China)
Search for more papers by this authorProf. Chun-Yang Cao
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
Search for more papers by this authorCorresponding Author
Prof. Zhan-Ting Li
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
Chemistry of Department, Fudan University, 220 Handan Road, Shanghai 200433 (China)
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)Search for more papers by this authorDr. Li-Yan You
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
These authors contributed equally to this project.
Search for more papers by this authorDr. Shi-Gui Chen
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
These authors contributed equally to this project.
Search for more papers by this authorCorresponding Author
Prof. Xin Zhao
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)Search for more papers by this authorProf. Yi Liu
The Molecular Foundry, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720 (USA)
Search for more papers by this authorDr. Wen-Xian Lan
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
Search for more papers by this authorYing Zhang
Chemistry of Department, Fudan University, 220 Handan Road, Shanghai 200433 (China)
Search for more papers by this authorProf. Hao-Jie Lu
Chemistry of Department, Fudan University, 220 Handan Road, Shanghai 200433 (China)
Search for more papers by this authorProf. Chun-Yang Cao
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
Search for more papers by this authorCorresponding Author
Prof. Zhan-Ting Li
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)
Chemistry of Department, Fudan University, 220 Handan Road, Shanghai 200433 (China)
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China)Search for more papers by this authorWe thank NSFC (20921091 and 20974118) and STCSM (10J1412200 and 09XD1405300) for financial support.
Graphical Abstract
Into the fold: Intramolecular CH⋅⋅⋅O hydrogen bonding has been utilized to create new aromatic triazole foldamers. Remarkably, all the triazole units of the foldamers are guided to orientate inward to form a nitrogen ring. As a result, they can efficiently bind neutral tri- and didentate organohalogens through multiple N⋅⋅⋅X (X=Cl, Br, I) halogen bonds to form stable 1:1 complexes.
Supporting Information
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