Structural Basis of β-Amyloid-Dependent Synaptic Dysfunctions†
Dr. Christian Haupt
Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Jörg Leppert
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Raik Rönicke
DZNE-Standort Magdeburg c/o Leibniz-Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Jessica Meinhardt
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Search for more papers by this authorDr. Jay K. Yadav
Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Search for more papers by this authorDr. Ramadurai Ramachandran
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Search for more papers by this authorDr. Oliver Ohlenschläger
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Search for more papers by this authorProf. Dr. Klaus G. Reymann
DZNE-Standort Magdeburg c/o Leibniz-Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg (Germany)
Search for more papers by this authorCorresponding Author
Dr. Matthias Görlach
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Matthias Görlach, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Marcus Fändrich, Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Search for more papers by this authorCorresponding Author
Priv.-Doz. Dr. Marcus Fändrich
Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Matthias Görlach, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Marcus Fändrich, Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Search for more papers by this authorDr. Christian Haupt
Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Jörg Leppert
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Raik Rönicke
DZNE-Standort Magdeburg c/o Leibniz-Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Jessica Meinhardt
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Search for more papers by this authorDr. Jay K. Yadav
Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Search for more papers by this authorDr. Ramadurai Ramachandran
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Search for more papers by this authorDr. Oliver Ohlenschläger
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Search for more papers by this authorProf. Dr. Klaus G. Reymann
DZNE-Standort Magdeburg c/o Leibniz-Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg (Germany)
Search for more papers by this authorCorresponding Author
Dr. Matthias Görlach
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Matthias Görlach, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Marcus Fändrich, Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Search for more papers by this authorCorresponding Author
Priv.-Doz. Dr. Marcus Fändrich
Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Matthias Görlach, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena (Germany)
Marcus Fändrich, Max Planck Research Unit for Enzymology of Protein Folding & MLU, Weinbergweg 22, 06120 Halle (Saale) (Germany)
Search for more papers by this authorThe authors thank K. Böhm for technical assistance. The Leibniz Institute for Age Research is financially supported by the State of Thuringia and the Federal Government of Germany. K.G.R. and M.F. are supported by the country Sachsen-Anhalt (Exzellenznetzwerk Biowissenschaften). M.F. was additionally supported by grants from the DFG (SFB 610) and the BMBF (BioFuture).
Graphical Abstract
Learn about Alzheimer: The molecular conformation of a toxic β-amyloid oligomer structure was determined by NMR spectroscopy (see picture). The measurements show a N-terminal β strand that controls the partitioning between oligomer and protofibril formation. Targeting the N-terminus of the peptide neutralizes Aβ-dependent neuronal dysfunctions. The data have important implications for understanding the structural basis of Alzheimer's disease.
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