Externally Triggered Glass Transition Switch for Localized On-Demand Drug Delivery†
Jos T. F. Keurentjes Prof. Dr. Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorMaartje F. Kemmere Dr. Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorHenny Bruinewoud Dr. Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorMicky A. M. E. Vertommen Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorStefan A. Rovers Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorRichard Hoogenboom Dr.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorLéon F. S. Stemkens Ing.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorFabiènne L. A. M. A. Péters Ing.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorNaomi J. C. Tielen Dr.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorDirk T. A. van Asseldonk Dr. Ir.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorAnne F. Gabriel
Pain Management and Research Center, Department of Anaesthesiology, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht (The Netherlands)
Search for more papers by this authorElbert A. Joosten Dr.
Pain Management and Research Center, Department of Anaesthesiology, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht (The Netherlands)
Search for more papers by this authorMarco A. E. Marcus Prof. Dr.
Pain Management and Research Center, Department of Anaesthesiology, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht (The Netherlands)
Search for more papers by this authorJos T. F. Keurentjes Prof. Dr. Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorMaartje F. Kemmere Dr. Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorHenny Bruinewoud Dr. Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorMicky A. M. E. Vertommen Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorStefan A. Rovers Ir.
Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
Search for more papers by this authorRichard Hoogenboom Dr.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorLéon F. S. Stemkens Ing.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorFabiènne L. A. M. A. Péters Ing.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorNaomi J. C. Tielen Dr.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorDirk T. A. van Asseldonk Dr. Ir.
Dolphys Medical B.V. Den Dolech 2, 5612 AZ Eindhoven (The Netherlands)
Search for more papers by this authorAnne F. Gabriel
Pain Management and Research Center, Department of Anaesthesiology, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht (The Netherlands)
Search for more papers by this authorElbert A. Joosten Dr.
Pain Management and Research Center, Department of Anaesthesiology, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht (The Netherlands)
Search for more papers by this authorMarco A. E. Marcus Prof. Dr.
Pain Management and Research Center, Department of Anaesthesiology, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht (The Netherlands)
Search for more papers by this authorThis work was financially supported by SenterNovem.
Graphical Abstract
I want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).
Supporting Information
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