Multiple CH Activations To Construct Biologically Active Molecules in a Process Completely Free of Organohalogen and Organometallic Components†
Bi-Jie Li
College of Chemistry, Peking University, Beijing 100871, China
Search for more papers by this authorShi-Liang Tian
College of Chemistry, Peking University, Beijing 100871, China
Search for more papers by this authorZhao Fang
College of Chemistry, Peking University, Beijing 100871, China
Search for more papers by this authorZhang-Jie Shi
Beijing National Laboratory of Molecular Sciences (BNLMS), PKU Green Chemistry Centre and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China, http://www.shigroup.cn/
State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, Fax: (+86) 10-6276-0890)
Search for more papers by this authorBi-Jie Li
College of Chemistry, Peking University, Beijing 100871, China
Search for more papers by this authorShi-Liang Tian
College of Chemistry, Peking University, Beijing 100871, China
Search for more papers by this authorZhao Fang
College of Chemistry, Peking University, Beijing 100871, China
Search for more papers by this authorZhang-Jie Shi
Beijing National Laboratory of Molecular Sciences (BNLMS), PKU Green Chemistry Centre and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China, http://www.shigroup.cn/
State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, Fax: (+86) 10-6276-0890)
Search for more papers by this authorSupport of this work by a starter grant from Peking University and the grant from National Sciences Foundation of China (No. 20542001, 20521202, 20672006) is gratefully acknowledged.
Graphical Abstract
Step by step: Highly selective cross dehydrogenative arylation of acetanilides was developed to construct biaryls under mild condition. With this method, different aryl CH bonds were activated in sequential reactions to construct functionalized carbazoles (see scheme), which are present as key structural units in various biological molecules and organic optical materials.
Supporting Information
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Citing Literature
January 25, 2008
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