Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-alkenes†
G. K. Surya Prakash Prof. Dr.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorJinbo Hu Dr.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorYing Wang
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorGeorge A. Olah Prof. Dr.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorG. K. Surya Prakash Prof. Dr.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorJinbo Hu Dr.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorYing Wang
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorGeorge A. Olah Prof. Dr.
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA, Fax: (+1) 213-740-6270
Search for more papers by this authorSupport of our work by Loker Hydrocarbon Research Institute is gratefully acknowledged.
Graphical Abstract
A nucleophilic substitution–elimination reaction strategy in which difluoromethyl phenyl sulfone is used as a selective difluoromethylidene equivalent allows the facile synthesis of 1,1-difluoro-1-alkenes from primary alkyl halides (see scheme).
Supporting Information
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