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Efficient Hydration of Nitriles to Amides in Water, Catalyzed by Ruthenium Hydroxide Supported on Alumina^†

Kazuya Yamaguchi Dr.

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7220

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Mitsunori Matsushita,

Mitsunori Matsushita

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7220

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Noritaka Mizuno Prof. Dr.,

Noritaka Mizuno Prof. Dr.

[email protected]

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7220

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Kazuya Yamaguchi Dr.,

Kazuya Yamaguchi Dr.

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7220

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Mitsunori Matsushita,

Mitsunori Matsushita

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7220

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Noritaka Mizuno Prof. Dr.,

Noritaka Mizuno Prof. Dr.

[email protected]

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7220

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First published: 09 March 2004

https://doi.org/10.1002/anie.200353461

Citations: 222

^†

This work was supported in part by the Core Research for Evolutional Science and Technology (CREST) program of Japan Science and Technology Agency (JST) and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Graphical Abstract

A broad range of amides is accessible in excellent yield (>99 %) by hydration of the corresponding nitriles in water in the presence of the supported ruthenium catalyst Ru(OH)_x/Al₂O₃ (see scheme). For example, the industrially important conversion of acrylonitrile into acrylamide was achieved in quantitative yield and better than 99 % selectivity. The catalyst can be reused without loss of catalytic activity and selectivity.

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Volume43, Issue12

March 12, 2004

Pages 1576-1580

Efficient Hydration of Nitriles to Amides in Water, Catalyzed by Ruthenium Hydroxide Supported on Alumina^†

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Efficient Hydration of Nitriles to Amides in Water, Catalyzed by Ruthenium Hydroxide Supported on Alumina†

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Efficient Hydration of Nitriles to Amides in Water, Catalyzed by Ruthenium Hydroxide Supported on Alumina^†