Mixed Helices—A General Folding Pattern in Homologous Peptides?†
Carsten Baldauf Dipl.-Biochem.
Institut für Biochemie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany, Fax: (+49) 341-973-6998
Search for more papers by this authorRobert Günther Dr.
Institut für Biochemie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany, Fax: (+49) 341-973-6998
Search for more papers by this authorHans-Jörg Hofmann Prof.
Institut für Biochemie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany, Fax: (+49) 341-973-6998
Search for more papers by this authorCarsten Baldauf Dipl.-Biochem.
Institut für Biochemie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany, Fax: (+49) 341-973-6998
Search for more papers by this authorRobert Günther Dr.
Institut für Biochemie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany, Fax: (+49) 341-973-6998
Search for more papers by this authorHans-Jörg Hofmann Prof.
Institut für Biochemie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany, Fax: (+49) 341-973-6998
Search for more papers by this authorThis work was supported by the Deutsche Forschungsgemeinschaft (Project HO2346/1 “Sekundärstrukturbildung in Peptiden mit nicht-proteinogenen Aminosäuren” and SFB 610 “Proteinzustände mit zellbiologischer und medizinischer Relevanz”) and the Fonds der Chemischen Industrie.
Graphical Abstract
You may now exchange rings! “Mixed helices” along a peptide sequence, in which rings of different sizes are held together by hydrogen bonds in alternating directions (see picture), prove to be a general folding principle in homologous α-, β-, γ-, and δ-peptides.
Supporting Information
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