Self-Assembled Aggregates of IgGs as Templates for the Growth of Clusters of Gold Nanoparticles†
Jerry Yang Prof.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorMichael Mayer Dr.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorJennah K. Kriebel
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorPiotr Garstecki Dr.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorGeorge M. Whitesides Prof.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorJerry Yang Prof.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorMichael Mayer Dr.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorJennah K. Kriebel
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorPiotr Garstecki Dr.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorGeorge M. Whitesides Prof.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Fax (+1) 617-495-9857
Search for more papers by this authorThis work was supported by the NIH (Grant GM30367). M.M. acknowledges the Swiss National Science Foundation for a postdoctoral fellowship. J.K. acknowledges support from the NDSEG for a predoctoral fellowship. P.G acknowledges the Foundation for Polish Science for a postdoctoral fellowship. We thank Dr. Declan Ryan for helpful discussions. IgGs=Immunoglobulin Gs.
Graphical Abstract
Immunoglobulin G templates: Clusters of gold nanoparticles are grown (see picture) from templates formed from the self-assembly of immunoglobulin Gs (IgGs) by using a synthetic divalent antigen. Carbohydrates inherent to IgGs create local nucleation centers for the electroless deposition of gold.
Supporting Information
Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53161_s.pdf or from the author.
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