Catechol-Isolated Atomically Dispersed Nanocatalysts for Self-Motivated Cocatalytic Tumor Therapy
Dr. Yuemei Wang
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorShuwen Qiu
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorDr. Liping Wang
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorDr. Penghao Ji
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Yuedong Guo
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorHeliang Yao
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Search for more papers by this authorChenyang Wei
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Minfeng Huo
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorProf. Jianlin Shi
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Yuemei Wang
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorShuwen Qiu
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorDr. Liping Wang
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorDr. Penghao Ji
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Yuedong Guo
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorHeliang Yao
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Search for more papers by this authorChenyang Wei
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Minfeng Huo
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorProf. Jianlin Shi
Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Shanghai Institute of Ceramics, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050 P. R. China
Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, 200072 P. R. China
Search for more papers by this authorAbstract
Nanocatalytic tumor therapy based on Fenton nanocatalysts has attracted considerable attention because of its therapeutic specificity, enhanced outcomes, and high biocompatibility. Nevertheless, the rate-determining step in Fenton chemistry, which involves the transition of a high-valence metallic center (FeIII) to a Fenton-active low-valence metallic center (FeII), has hindered advances in nanocatalyst-based therapeutics. In this study, we constructed mesoporous single iron atomic nanocatalysts (mSAFe NCs) by employing catechols from dopamine to coordinate and isolate single iron atoms. The catechols also serve as reductive ligands, generating a field-effect-based cocatalytic system that instantly reduces FeIII species to FeII species within the mSAFe NCs. This self-motivated cocatalytic strategy enabled by mSAFe NCs accelerates the kinetics of the Fenton catalytic reaction, resulting in remarkable performance for nanocatalytic tumor therapy both in vitro and in vivo.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
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