Fast Isomerization Before Isomerization-Hydroformylation: Probing the Neglected Period with A Novel Microfluidic Device
Dr. Fanfu Guan
Department of Chemical Process R&D, Lianyungang Institute of Research, Jiangsu Hengrui Pharmaceuticals Co., Ltd., 7 Kunlunshan Road, Lianyungang, 222000 China
These authors contributed equally to this work.
Search for more papers by this authorYu Qian
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
These authors contributed equally to this work.
Search for more papers by this authorPeiqi Zhang
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
Search for more papers by this authorDr. Runtong Zhang
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
Search for more papers by this authorCorresponding Author
Prof. Xumu Zhang
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
Search for more papers by this authorCorresponding Author
Dr. Jialin Wen
Department of Chemical Process R&D, Lianyungang Institute of Research, Jiangsu Hengrui Pharmaceuticals Co., Ltd., 7 Kunlunshan Road, Lianyungang, 222000 China
Search for more papers by this authorDr. Fanfu Guan
Department of Chemical Process R&D, Lianyungang Institute of Research, Jiangsu Hengrui Pharmaceuticals Co., Ltd., 7 Kunlunshan Road, Lianyungang, 222000 China
These authors contributed equally to this work.
Search for more papers by this authorYu Qian
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
These authors contributed equally to this work.
Search for more papers by this authorPeiqi Zhang
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
Search for more papers by this authorDr. Runtong Zhang
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
Search for more papers by this authorCorresponding Author
Prof. Xumu Zhang
Guangdong Provincial Key Laboratory of Catalysis, Department of Chemistry, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055 China
Search for more papers by this authorCorresponding Author
Dr. Jialin Wen
Department of Chemical Process R&D, Lianyungang Institute of Research, Jiangsu Hengrui Pharmaceuticals Co., Ltd., 7 Kunlunshan Road, Lianyungang, 222000 China
Search for more papers by this authorAbstract
By combining the concept of flash chemistry and radial synthesis, a novel microreactor (Flashstop reactor) was designed to study isomerization process of hydroformylation by a Rh/tetraphosphite catalyst in a time scale of seconds. It was found that in the initial 313 seconds, 60–99 % of 1-octene was isomerized to 2- and 3-octenes before the formation of aldehydes. Within this period, two different types of isomerization reactions were observed. It was proposed that a monohydride complex without CO ligand accounts for the ultrafast isomerization in the initial 30 seconds. The isomerization rate with such monohydride species was calculated much faster than that with the well-known H(CO)Rh(P−P) species. Both experimental and DFT computational studies were carried out to support this assumption. Fast transformations early on in catalytic cycles have been rarely studied due to the lack of proper tools. We believe that the Flashstop reactor is a powerful tool for analysis of kinetics in gas-liquid biphasic reactions within a time scale of seconds to minutes.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
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