Kurzaufsatz
Klinische Entwicklung von Metallkomplexen als Photosensibilisatoren für die photodynamische Therapie von Krebs
Dr. Johannes Karges,
Corresponding Author
Dr. Johannes Karges
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093 USA
Search for more papers by this authorDr. Johannes Karges,
Corresponding Author
Dr. Johannes Karges
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093 USA
Search for more papers by this authorAbstract
Krebs hat sich in den letzten Jahrzehnten zu einer der häufigsten krankheitsbedingten Todesursachen der Welt entwickelt. Neben den am häufigsten angewendeten Techniken (Chirurgie, Immuntherapie, Strahlentherapie oder Chemotherapie) wird der photodynamischen Therapie zunehmend Aufmerksamkeit gewidmet. Die überwiegende Mehrheit der klinisch eingesetzten Photosensibilisatoren ist jedoch nicht ideal und weist mehrere Einschränkungen auf, darunter schlechte Wasserlöslichkeit, schlechte Photostabilität und langsame Ausscheidung aus dem Körper, was zu Photosensibilität führt. In dem Bemühen, diese Nachteile zu überwinden, wird der Einbindung eines Metallions viel Aufmerksamkeit gewidmet. In diesem Kurzaufsatz wird die klinische Entwicklung von metallhaltigen Verbindungen wie Purlytin®, Lutrin®/Antrin®, Photosens®, TOOKAD® soluble oder TLD-1433 kritisch diskutiert.
Interessenkonflikt
Der Autor erklärt, dass keine Interessenkonflikte vorliegen.
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