Innenrücktitelbild: A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery (Angew. Chem. 12/2020)

Dr. Lanfang Ren

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241 China

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Dr. Jia Lv,

Dr. Jia Lv

South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, 510640 China

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Prof. Dr. Hui Wang,

Prof. Dr. Hui Wang

South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, 510640 China

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Prof. Dr. Yiyun Cheng,

Corresponding Author

Prof. Dr. Yiyun Cheng

[email protected]

orcid.org/0000-0001-6019-5645

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241 China

South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, 510640 China

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Dr. Lanfang Ren,

Dr. Lanfang Ren

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241 China

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Dr. Jia Lv,

Dr. Jia Lv

South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, 510640 China

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Prof. Dr. Hui Wang,

Prof. Dr. Hui Wang

South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, 510640 China

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Prof. Dr. Yiyun Cheng,

Corresponding Author

Prof. Dr. Yiyun Cheng

[email protected]

orcid.org/0000-0001-6019-5645

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241 China

South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, 510640 China

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First published: 26 February 2020

https://doi.org/10.1002/ange.202002155

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Graphical Abstract

Ein koordinatives Dendrimer transportiert 30 verschiedene Proteine und Peptide in das Zytosol lebender Zellen, wobei ihre Bioaktivität nach der intrazellulären Freisetzung erhalten bleibt. In ihrem Forschungsartikel auf S. 4741 berichten Y. Cheng et al., wie die mit einem Dipicolylamin/Zink(II)-Komplex modifizierten Dendrimere in der Lage sind, Proteine durch eine Kombination aus ionischen und koordinativen Wechselwirkungen zu binden. Dies zeigt eine neue Strategie zur Entwicklung robuster und effizienter Polymere für die zytosolische Proteinfreisetzung auf.