Titelbild

Free Access

Rücktitelbild: A D-Peptide Ligand of Nicotine Acetylcholine Receptors for Brain-Targeted Drug Delivery (Angew. Chem. 10/2015)

Xiaoli Wei

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032 (P.R. China)

Search for more papers by this author

Dr. Changyou Zhan,

Corresponding Author

Dr. Changyou Zhan

[email protected]

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)Search for more papers by this author

Qing Shen,

Qing Shen

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Prof. Wei Fu,

Prof. Wei Fu

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Cao Xie,

Cao Xie

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Jie Gao,

Jie Gao

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Chunmei Peng,

Chunmei Peng

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Prof. Ping Zheng,

Prof. Ping Zheng

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032 (P.R. China)

Search for more papers by this author

Prof. Weiyue Lu,

Corresponding Author

Prof. Weiyue Lu

[email protected]

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032 (P.R. China)

State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 (P.R. China)

Xiaoli Wei,

Xiaoli Wei

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032 (P.R. China)

Search for more papers by this author

Dr. Changyou Zhan,

Corresponding Author

Dr. Changyou Zhan

[email protected]

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Qing Shen,

Qing Shen

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Prof. Wei Fu,

Prof. Wei Fu

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Cao Xie,

Cao Xie

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Jie Gao,

Jie Gao

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Chunmei Peng,

Chunmei Peng

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

Search for more papers by this author

Prof. Ping Zheng,

Prof. Ping Zheng

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032 (P.R. China)

Search for more papers by this author

Prof. Weiyue Lu,

Corresponding Author

Prof. Weiyue Lu

[email protected]

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, 201203 (P.R. China)

State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032 (P.R. China)

State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 (P.R. China)

First published: 04 February 2015

https://doi.org/10.1002/ange.201500512

Share a link

Email
Wechat
Bluesky

Graphical Abstract

Peptidliganden …︁ …︁ vermitteln den Transport von Wirkstoffen in das Gehirn, indem sie kognate Rezeptoren auf Gehirn-Endothelzellen “entführen". Ein Problem dabei ist, dass Enzyme L-Peptide inaktivieren und die Transportfähigkeit beschneiden. In ihrer Zuschrift auf S. 3066 ff. identifizieren W. Lu, C. Zhan et al. einen D-Peptidliganden von Nicotinacetylcholin-Rezeptoren, der resistent gegen Proteolyse ist und bessere Transporteigenschaften als der L-Peptidligand aufweist.