Sequence-Selective Molecular Recognition between β Sheets†
James S. Nowick Prof.
Department of Chemistry, University of California, Irvine, Irvine, CA 92697-2025, USA, Fax: (+1) 949-824-9920
Search for more papers by this authorDe Michael Chung
Department of Chemistry, University of California, Irvine, Irvine, CA 92697-2025, USA, Fax: (+1) 949-824-9920
Search for more papers by this authorJames S. Nowick Prof.
Department of Chemistry, University of California, Irvine, Irvine, CA 92697-2025, USA, Fax: (+1) 949-824-9920
Search for more papers by this authorDe Michael Chung
Department of Chemistry, University of California, Irvine, Irvine, CA 92697-2025, USA, Fax: (+1) 949-824-9920
Search for more papers by this authorWe thank the NIH for grant support (GM-49076). D.M.C. thanks the Bill and Melinda Gates Foundation and the UCI Institute for Brain Aging and Dementia for a fellowship and training grant support (NIA-5T32AG000096).
Graphical Abstract
Sequenzselektive molekulare Erkennung zwischen Peptiden mit β-Faltblatt-Sekundärstruktur: Lediglich durch gezielte Positionierung zweier Threonin(Thr)- oder Valin(Val)-Reste lassen sich Peptide erhalten, die bevorzugt entweder Homodimere oder Heterodimere bilden. Gezeigt ist die Struktur eines Thr-Val⋅Val-Thr-Heterodimers.
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