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Biomedical Applications of Magnetic Nanoparticles
Daniel Ortega,
Daniel Ortega
Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Madrid, Spain
Centro Nacional de Biotecnologa (CNB-CSIC) - IMDEA Nanociencia Associated Unit “Unidad de Nanobiotecnologa”, Madrid, Spain
University College London, London, UK
Search for more papers by this authorDaniel Ortega,
Daniel Ortega
Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Madrid, Spain
Centro Nacional de Biotecnologa (CNB-CSIC) - IMDEA Nanociencia Associated Unit “Unidad de Nanobiotecnologa”, Madrid, Spain
University College London, London, UK
Search for more papers by this authorFirst published: 14 June 2015
Update based on the original article by Nand Kishore Prasad, Dhirendra Bahadur, Sébastien Vasseur and Etienne Duguet, Encyclopedia of Inorganic Chemistry © 2005 John Wiley & Sons, Ltd
Abstract
Magnetism, which is an intrinsic property of every atom, has a profound influence on living organisms. Magnetism of nanoparticles plays a strong role in certain specific applications of health care. More particularly, several magnetic inorganic oxides, such as iron oxides, which are biocompatible, have been extensively used for several medical applications in their nanometric form. These applications/perspectives include magnetic resonance imaging (MRI) contrast enhancement, hyperthermia treatment of cancer, targeted drug delivery, biological separation or sensing, as well as magnetically aided cell and gene therapies. This article examines these applications through the understanding of the problems involved and the current and future possibilities for resolving them.
References
- 1U. Häfeli, in Magnetism in Medicine: A Handbook, 2nd edition, eds W. Andrä and H. Nowak, Wiley-VCH Verlag, Berlin, 1998, p. 1.
- 2D. Arcos and M. Vallet-Regí, Acta Mater., 2013, 61, 890.
- 3S. Mornet, S. Vasseur, F. Grasset, and E. Duguet, J. Mater. Chem., 2004, 14, 2161.
- 4Q. A. Pankhurst, N. T. K. Thanh, S. K. Jones, and J. Dobson, J. Phys. D. Appl. Phys., 2009, 42, 224001.
- 5A. Ito, M. Shinkai, H. Honda, and T. Kobayashi, J. Biosci. Bioeng., 2005, 100, 1.
- 6E. Duguet, S. Vasseur, S. Mornet, and J.-M. Devoisselle, Nanomedicine, 2006, 1, 157.
- 7A. H. Lu, E. L. Salabas, and F. Schuth, Angew. Chem. Int. Ed. Engl., 2007, 46, 1222.
- 8L. H. Reddy, J. Arias, J. Nicolas, and P. Couvreur, Chem. Rev., 2012, 112, 5818.
- 9M. Colombo, S. Carregal Romero, M. Casula, L. Gutiérrez, M. Morales, I. Böhm, J. Heverhagen, D. Prosperi, and W. Parak, Chem. Soc. Rev., 2012, 41, 4306.
- 10J. M. D. Coey, Magnetism and Magnetic Materials, Cambridge University Press, Cambridge, 2010.
10.1017/CBO9780511845000 Google Scholar
- 11L. Gutierrez, R. Costo, C. Gruttner, F. Westphal, N. Gehrke, D. Heinke, A. Fornara, Q. A. Pankhurst, C. Johansson, S. Veintemillas-Verdaguer, and M. P. Morales, Dalton Trans., 2015, 44, 2943.
- 12D. Stanicki, L. Elst, R. N. Muller, and S. Laurent, Curr. Opin. Chem. Eng., 2015, 6, 7.
10.1016/j.coche.2015.01.003 Google Scholar
- 13R. Massart, IEEE Trans. Magn., 1981, 17, 1247.
- 14N. K. Prasad, D. Panda, S. Singh, and D. Bahadur, IEEE Trans. Magn., 2005, 41, 4099.
- 15 U. Häfeli, W. Schütt, J. Teller, and M. Zborowski (eds), Scientific and Clinical Applications of Magnetic Carriers, Plenum Press, New York, 1997, p. 205.
- 16Q. A. Pankhurst, J. Connolly, S. K. Jones, and J. Dobson, J. Phys. D. Appl. Phys., 2003, 36, R167.
- 17R. Hergt and W. Andrä, in Magnetism in Medicine: A Handbook 2nd edition, eds W. Andrä and H. Nowak, Wiley-VCH Verlag, Berlin, 1998, p. 1.
- 18D. Ortega and Q. A. Pankhurst, in Nanoscience: Nanostructures through Chemistry, ed P. O'Brien, Royal Society of Chemistry, Cambridge, 2012, Vol. 1, p. 60.
- 19A. E. Deatsch and B. A. Evans, J. Magn. Magn. Mater., 2014, 354, 163.
- 20E. Y. Sun, L. Josephson, K. A. Kelly, and R. Weissleder, Bioconj. Chem., 2005, 17, 109.
- 21J. Gao, L. Li, P. L. Ho, G. C. Mak, H. Gu, and B. Xu, Adv. Mater., 2006, 18, 3145.
- 22G. Wang and X. Su, Analyst, 2011, 136, 1783.
- 23H.-S. Cho, Z. Dong, G. M. Pauletti, J. Zhang, H. Xu, H. Gu, L. Wang, R. C. Ewing, C. Huth, F. Wang, and D. Shi, ACS Nano, 2010, 4, 5398.
- 24F. Wiekhorst, U. Steinhoff, D. Eberbeck, and L. Trahms, Pharm. Res., 2012, 29, 1189.
- 25D. Soukup, S. Moise, E. Céspedes, J. Dobson, and N. D. Telling, ACS Nano, 2015. DOI: 10.1021/nn503888j.
- 26Y. Okuhata, Adv. Drug Deliv. Rev., 1999, 37, 121.
- 27S. M. Moghimi, A. C. Hunter, and J. C. Murray, Pharmacol. Rev., 2001, 53, 283.
- 28C. Monfardini and F. M. Veronese, Bioconj. Chem., 1998, 9, 418.
- 29N. Schleich, F. Danhier, and V. Preat, J. Control. Release, 2015, 198C, 35.
- 30B. Bonnemain, J. Drug Target., 1998, 6, 167.
- 31D. Högemann, L. Josephson, R. Weissleder, and J. P. Basilion, Bioconj. Chem., 2000, 11, 941.
- 32A. Seifalian, E. Bull, M. Madani, A. Sheth, M. Green, and A. M. Seifalian, Int. J. Nanomedicine, 2014, 9, 1641.
- 33N. Lee and T. Hyeon, Chem. Soc. Rev., 2012, 41, 2575.
- 34F. Wallis and F. J. Gilbert, J. R. Coll. Surg. Edinb., 1999, 44, 117.
- 35Y.-X. J. Wang, Quant. Imaging Med. Surg., 2011, 1, 35.
- 36C. Corot, P. Robert, J.-M. Idée, and M. Port, Adv. Drug Deliv. Rev., 2006, 58, 1471.
- 37M. A. Pysz, S. S. Gambhir, and J. K. Willmann, Clin. Radiol., 2010, 65, 500.
- 38B. A. Duffy, A. J. Weitz, and J. H. Lee, Curr. Opin. Genet. Dev., 2014, 28C, 83.
- 39E. Saritas, P. Goodwill, L. Croft, J. Konkle, K. Lu, B. Zheng, and S. Conolly, J. Magn. Reson., 2013, 229, 116.
- 40P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, and P. M. Schlag, Lancet Oncol., 2002, 3, 487.
- 41E. Moros, Physics of Thermal Therapy: Fundamentals and Clinical Applications, CRC Press, Boca Raton, FL, 2012.
- 42A. L. Cortajarena, D. Ortega, S. M. Ocampo, A. Gonzalez-García, P. Couleaud, R. Miranda, C. Belda-Iniesta, and A. Ayuso-Sacido, Nanobiomedicine, 2014, 1, 2.
- 43R. K. Gilchrist, R. Medal, W. D. Shorey, R. C. Hanselman, J. C. Parrott, and C. B. Taylor, Ann. Surg., 1957, 146, 596.
- 44M. Johannsen, U. Gneveckow, L. Eckelt, A. Feussner, N. WaldÖFner, R. Scholz, S. Deger, P. Wust, S. A. Loening, and A. Jordan, Int. J. Hyperthermia, 2005, 21, 637.
- 45K. Maier-Hauff, F. Ulrich, D. Nestler, H. Niehoff, P. Wust, B. Thiesen, H. Orawa, V. Budach, and A. Jordan, J. Neuro-Oncol., 2011, 103, 317.
- 46A. Matsumine, K. Takegami, K. Asanuma, T. Matsubara, T. Nakamura, A. Uchida, and A. Sudo, Int. J. Clin. Oncol./Jpn. Soc. Clin. Oncol., 2011, 16, 101.
- 47J. Ruan, J. Ji, H. Song, Q. Qian, K. Wang, C. Wang, and D. Cui, Nanoscale Res. Lett., 2012, 7, 309.
- 48J. Delannoy, D. LeBihan, D. Hoult, and R. Levin, Med. Phys., 1990, 17, 855.
- 49E. Pollert, K. Knížek, M. Maryško, P. Kašpar, S. Vasseur, and E. Duguet, J. Magn. Magn. Mater., 2007, 316, 122.
- 50N. K. Prasad, K. Rathinasamy, D. Panda, and D. Bahadur, J. Biomed. Mater. Res. B Appl. Biomater., 2008, 85B, 409.
- 51M. Creixell, A. C. Bohórquez, M. Torres-Lugo, and C. Rinaldi, ACS Nano, 2011, 5, 7124.
- 52C. Sanchez, D. E. H. Diab, V. Connord, P. Clerc, E. Meunier, B. Pipy, B. Payre, R. P. Tan, M. Gougeon, J. Carrey, V. Gigoux, and D. Fourmy, ACS Nano, 2014, 8, 1350.
- 53U. Jeong, X. Teng, Y. Wang, H. Yang, and Y. Xia, Adv. Mater., 2007, 19, 33.
- 54D. Leslie-Pelecky, V. Labhasetwar, and R.Kraus Jr Nanobiomagnetics, in ‘Advanced Magnetic Nanostructures’, eds. D. J. Sellmyer and R. S. Skomski, Kluwer, New York, 2006.
- 55F. Sonvico, C. Dubernet, P. Colombo, and P. Couvreur, Curr. Pharm. Des., 2005, 11, 2091.
- 56A. S. Lübbe, C. Alexiou, and C. Bergemann, J. Surg. Res., 2001, 95, 200.
- 57S. Taherkhani, M. Mohammadi, J. Daoud, S. Martel, and M. Tabrizian, ACS Nano, 2014, 8, 5049.
- 58J. Kost, J. Wolfrum, and R. Langer, J. Biomed. Mater. Res., 1987, 21, 1367.
- 59B. Julian-Lopez, C. Boissiere, C. Chaneac, D. Grosso, S. Vasseur, S. Miraux, E. Duguet, and C. Sanchez, J. Mater. Chem., 2007, 17, 1563.
- 60P. J. A. Borm and D. Müller-Schulte, Nanomedicine, 2006, 1, 235.
- 61J. E. Wong, A. Krishnakumar Gaharwar, D. Müller-Schulte, D. Bahadur, and W. Richtering, J. Magn. Magn. Mater., 2007, 311, 219.
- 62S. Mura, J. Nicolas, and P. Couvreur, Nat. Mater., 2013, 12, 991.
- 63E. Mayes, M. Douek, and Q. A. Pankhurst, in Magnetic Nanoparticles: From Fabrication to Biomedical and Clinical Applications, ed N. T. K. Thanh, CRC Press, Boca Raton, 2011, p. 541.
- 64C. Plank, V. Dialechti, Y. Sanchez-Antequera, and O. Mykhaylyk, in Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, ed N. S. Templeton, CRC Press, Boca Raton, 2015.
- 65A. Fouriki, M. A. Clements, N. Farrow, and J. Dobson, J Tissue Eng Regen Med, 2014, 8, 169.
- 66J. Riegler, A. Liew, S. O. Hynes, D. Ortega, T. O'Brien, R. M. Day, T. Richards, F. Sharif, Q. A. Pankhurst, and M. F. Lythgoe, Biomaterials, 2013, 34, 1987.
