3 Prokaryotic Systems Biology
Annual Plant Reviews book series, Volume 35: Plant Systems Biology
I. Systems Biology: An Overview
Thadeous Kacmarczyk,
Peter Waltman,
Richard Bonneau,
Thadeous Kacmarczyk
Department of Biology and Center for Genomics and Systems Biology, New York University, New York, NY, USA
Search for more papers by this authorPeter Waltman
Computer Science Department, Courant Institute for Mathematical Sciences, New York University, New York, NY, USA
Search for more papers by this authorRichard Bonneau
Department of Biology and Center for Genomics and Systems Biology, New York University, New York, NY, USA
Computer Science Department, Courant Institute for Mathematical Sciences, New York University, New York, NY, USA
Search for more papers by this authorThadeous Kacmarczyk,
Peter Waltman,
Richard Bonneau,
Thadeous Kacmarczyk
Department of Biology and Center for Genomics and Systems Biology, New York University, New York, NY, USA
Search for more papers by this authorPeter Waltman
Computer Science Department, Courant Institute for Mathematical Sciences, New York University, New York, NY, USA
Search for more papers by this authorRichard Bonneau
Department of Biology and Center for Genomics and Systems Biology, New York University, New York, NY, USA
Computer Science Department, Courant Institute for Mathematical Sciences, New York University, New York, NY, USA
Search for more papers by this authorFirst published: 24 April 2018
This article was originally published in 2009 in Plant Systems Biology, Volume 35 (ISBN 9781405162838) of the Annual Plant Reviews book series, this volume edited by Gloria M. Coruzzi and Rodrigo A. Gutíerrez. The article was republished in Annual Plant Reviews online in April 2018.
Abstract
This chapter will briefly review the most common technologies employed in prokaryotic systems biology projects. When possible, we will highlight the relevance to prokaryotic biology and the role prokaryotic systems might have had in the inception of the technology overall. We will then walk the reader through four functional genomics projects. Although this review cannot cover all details of the full, field-wide, efforts directed at even a single organism, we do think it is instructive to attempt to outline the efforts directed to each of these systems. We wish to highlight the biological insights gleaned from these studies and demonstrate that these studies illustrate a very productive interface between systems biology, computational biology and more traditional (small numbers of genes) molecular biology that is already in operation in the studies we review.
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