6 New Medical Applications of Plant Secondary Metabolites (From APR Volume 3)
Annual Plant Reviews book series, Volume 3: Functions of Plant Secondary Metabolities and their Exploitation in Biotechnology
Jörg Heilmann,
Rudolf Bauer,
Jörg Heilmann
Departement Pharmazie, ETH Zürich, Winterthurerstrasse 190, Zürich, CH-8057 Switzerland
Search for more papers by this authorRudolf Bauer
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universitát Düsseldorf, Universitátsstrasse 1, Düsseldorf, D-40225 Germany
Search for more papers by this authorJörg Heilmann,
Rudolf Bauer,
Jörg Heilmann
Departement Pharmazie, ETH Zürich, Winterthurerstrasse 190, Zürich, CH-8057 Switzerland
Search for more papers by this authorRudolf Bauer
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universitát Düsseldorf, Universitátsstrasse 1, Düsseldorf, D-40225 Germany
Search for more papers by this authorFirst published: 19 April 2018
This article was originally published in 1999 in Functions of Plant Secondary Metabolities and their Exploitation in Biotechnology, Volume 3 (ISBN 9781841270081) of the Annual Plant Reviews book series, this volume edited by Michael Wink. The article was republished in Annual Plant Reviews online in April 2018.
Abstract
The sections in this article are
- Introduction
- Compounds with Anticancer Activity
- Antiviral Compounds
- Antimalarial Drugs
- Anti-Inflammatory Drugs
- Antidepressant Drugs
- Anti-Ischaemic Drugs
- Immunostimulatory Drugs
- Conclusion
References
- Adlercreutz, H. and Mazur, W. (1997) Phyto-oestrogens and Western diseases. Ann. Med., 29 95-120.
-
Ahlemeyer, B. and Krieglstein, J. (1998) Neuroprotective effects of Ginkgo biloba extract, in Phytomedicines of Europe: Chemistry and Biological Activity (eds. L.D. Lawson and R. Bauer), ACS Symposium Series 691, ACS Books, Washington, pp. 210-20.
10.1021/bk-1998-0691.ch015 Google Scholar
- Akiyama, T. and Ogawara, H. (1991) Use and specificity of genistein as inhibitor of protein tyrosine kinases. Methods Enzymol., 201 362-70.
- Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M. and Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262 5592-95.
- Amlot, P.L., Stone, M.J., Cunningham, D., Fay, J., Newman, J., Collins, R., May, R., McCarthy, M., Richardson, J., Ghetie, V., Ramilo, O., Thorpe, P.E., Uhr, J.W. and Vitetta, E.S. (1993) A Phase I study of an anti-CD22-deglycosylated ricin A-chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy. Blood, 82 2624-33.
- Ammon, H.P.T., Safayhi, H., Mack, T. and Sabieraj, J. (1993) Mechanism of anti-inflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol., 38 113-19.
-
Amri, H., Ogwuegbu, S.O., Boujrad, N., Drieu, K. and Papadopoulos, V. (1996)
In vivo regulation of the peripheral-type benzodiazepine receptor and glucocorticoid synthesis by the Ginkgo biloba extract, EGb 761, and isolated ginkgolides. Endocrinology, 130
5707-18.
10.1210/endo.137.12.8940403 Google Scholar
- Amri, H., Drieu, K. and Papadopoulos, V. (1997) Ex-vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the Ginkgo biloba extract, EGb 761, and isolated ginkgolide B. Endocrinology, 138 5415-26.
- Arguello, F., Alexander, M., Sterry, J.A., Tudor, G., Smith, E.M., Kavalar, N.T., Greene, J.F. Jr, Koss, W., Morgan, C.D., Stinson, S.F., Siford, T.J., Alvord, W.G., Klabansky, R.L. and Sausville, A. (1998) Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood, 91 2482-90.
- Aruoma, O.I. (1994) Nutrition and health aspects of free radicals and antioxidants. Food Chem. Toxicol. 32 671-83.
- Barbieri, L., Aron, G.M., Irvin, J.D. and Stirpe, F. (1982) Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana (L.) (pokeweed). Biochem. J., 203 55-59.
- Barbieri, L., Battelli, M.G. and Stirpe, F. (1993) Ribosome-inactivating proteins from plants. Biochim. Biophys. Acta, 1154 237-82.
- Battelli, M.G., Montacuti, V. and Stirpe, F. (1992) High sensitivity of cultured human trophoblasts to ribosome-inactivating proteins. Exp. Cell Res., 201 109-12.
- Baureithel, K.H., Büter, K.B., Engesser, A., Burkard, W. and Schaffner, W. (1997) Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. Pharm. Acta Helv., 72 153-57.
- Benigni, F., Canevari, S., Gadina, M., Adobati, E., Ferreri, A.J.M., Di Celle, E.F., Comolli, R. and Colnaghi, M.I. (1995) Preclinical evaluation of the ribosome-inactivating proteins, PAP-1, PAP-S and RTA, in mice. Int. J. Immunopharmacol., 17 829-39.
- Beuth, J., Stoffel, B., Ko, H.L., Jeljaszewicz, J. and Pulverer, G. (1995) Immunomodulating ability of galactoside-specific lectin standardized and depleted mistletoe extract. Arzneim.-Forsch. Drug Res., 45 1240-42.
- Beutler, J.A., Cardelina II, J.H., McMahon, J.B., Shoemaker, R.H. and Boyd, M.R. (1995) Antiviral and antitumor metabolites, in Phytochemistry of Medicinal Plants (eds. J.T. Arnason, R. Mata and J.T. Romeo), Plenum Press, New York and London, pp. 47-64.
- Bible, K.C. and Kaufmann, S.H. (1996) Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res., 56 4856-61.
- Bible, K.C. and Kaufmann, S.H. (1997) Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration. Cancer Res., 57 3375-80.
- Bich, N.N., De-Vries, P.J., Van-Thien, H., Phong, T.H., Hung, L.N., Eggelte, T.A., Anh, T.K. and Kager, P.A. (1996) Efficacy and tolerance of artemisinin in short combination regimens for the treatment of uncomplicated falciparum malaria. Am. J. Trop. Med. Hyg., 55 438-43.
- Bolognesi, A., Barbieri, L., Abbondanza, A., Falasca, A.I., Carnicelli, D., Battelli, M.G. and Stirpe, F. (1990) Purification and properties of new ribosome-inactivating proteins with RNA N-glycosidase activity. Biochim. Biophys. Acta, 1087 293-302.
- Bonneterre, J. (1995) Topoisomerase I inhibitors: review of clinical phase II trials of irinotecan (CPT-11) and topotecan (FRE). Bull. Cancer, 82 623-28.
- Boyd, M.R., Hallock, Y.F., Cardellina II, J.H., Manfredi, K.P., Blunt, J.W., McMahon, J.B., Buckheit, R.W. Jr, Bringmann, G., Schäffer, M., Cragg, G.M., Thomas, D.W. and Jato, J.G. (1994) Anti-HIV michellamines from Ancistrocladus korupensis . J. Med. Chem., 37 1740-45.
- Braun, J.M., Gemmell, C.G., Beuth, J., Ko, H.L. and Pulverer, G. (1995) Respiratory burst of human polymorphonuclear leukocytes in response to the galactoside-specific mistletoe lectin. Int. J. Med. Microbiol. Virol. Parasitol. Infect. Dis., 283 90-94.
- Brewer, T.G., Grate, S.J., Peggins, J.O., Weina, P.J., Petras, J.M., Levine, B.S., Heiffer, M.H. and Schuster, B.G. (1994) Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg., 51 251-59.
- Büssing, A., Stein, G.M. and Pfueller, U. (1998) Selective killing of CD8+ cells with a memory phenotype (CD62L(lo)) by the N-acetyl-d-galactosamine-specific lectin from Viscum album (L.) Cell Death Differentiation, 5 231-40.
- Butterweck, V., Petereit, F., Winterhoff, H. and Nahrstedt, A. (1998) Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med., 64 291-94.
- Byers, V.S., Levin, A.S., Malvino, A., Waites, L., Robins, R.A. and Baldwin, R.W. (1994) A phase II study of effect of addition of trichosanthin to zidovudine in patients with HIV disease and failing antiretroviral agents. AIDS Res. Hum. Retroviruses, 10 413-20.
- Cao, X.T., Bethell, D.B., Pham, T.P., Ta, T.T., Tran, T.N., Nguyen, T.T., Pham, T.T., Nguyen, T.T., Day, N.P. and White, N.J. (1997) Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria. Trans. R. Soc. Trop. Med. Hyg., 91 335-42.
- Cardellina II, J.H., Bokesch, H.R., McKee, T.C. and Boyd, M.R. (1995) Resolution and comparative anti-HIV evaluation of the enantiomers of calanolides A and B. BioMed. Chem. Lett., 5 1011-14.
- Carlson, B.A., Dubay, M.M., Sausville, E.A., Brizuela, L. and Worland, P.J. (1996) Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res., 56 2973-76.
- Chatterjee, S.S., Nöldner, M., Koch, E. and Erdelmeier, C. (1998) Antidepressant activity of Hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiat., 31 7-15.
- Chenera, B., West, M.L., Finkelstein, J.A. and Dreyer, G.B. (1993) Total synthesis of (±)-calanolide A, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. J. Org. Chem., 58 5605-606.
- Ciomei, M., Albanese, C., Pastori, W., Grandi, M., Pietra, F., D'Ambrosio, M., Guerriero, A. and Battistini, C. (1997) Sarcodictyins: a new class of marine derivatives with mode of action similar to taxol. Proc. Am. Assoc. Cancer Res., 38 5 (Abstract 30).
- Clark, A.M. (1996) Natural products as a resource for new drugs. Pharm. Res., 13 1133-44.
- Collins, E.J., Robertus, J.D., LoPresti, M., Stone, K.L., Williams, K.R., Wu, P., Hwang, K. and Piatak, M. (1990) Primary amino acid sequence of α-trichosanthin and molecular models for abrin A-chain and α-trichosanthin. J. Biol. Chem., 265 8665-69.
- Conte, P.F., Gennari, A., Salvadori, B., Pazzagli, C. and Bengala, C. (1998) Paclitaxel plus epirubicin in advanced breast cancer. Oncology Huntingt., 12 40-44.
- Cott, J.M. (1997) In vitro receptor-binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiat., 30 108-12.
- Croom, E.M. Jr. (1995) Taxus for taxol and taxoids, in Taxol® Science and Applications (ed. M. Suffness), CRC Press, Boca Raton, New York, London, Tokyo, pp. 37-70.
- Currens, M.J., Gulakowski, R.J., Mariner, J.M., Moran, R.A., Buckheit, R.W. Jr, Gustafson, K.R., McMahon, J.B. and Boyd, M.R. (1996a) Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1. J. Pharmacol. Exp. Ther., 279 645-51.
- Currens, M.J., Mariner, J.M., McMahon, J.B. and Boyd, M.R. (1996b) Kinetic analysis of inhibition of human immunodeficiency type-1 reverse transcriptase by calanolide A. J. Pharmacol. Exp. Ther., 279 652-61.
- Czekalla, J., Gastpar, M., Hübner, W.D. and Jäger, D. (1997) The effect of Hypericum extract on cardiac conduction as seen in the electrocardiogram compared to that of imipramine. Pharmacopsychiat., 30 86-88.
- Damayanthi, Y. and Lown, J.W. (1998) Podophyllotoxins: current status and recent developments. Curr. Med. Chem., 5 205-52.
- Das, P.C., Roberts, J.D., White, S.L. and Olden, K. (1995) Activation of resident tissue-specific macrophages by swainsonine. Oncol. Res., 7 425-33.
- Dennis, J.W., Koch, K. and Beckner, D. (1989) Inhibition of human HT29 colon carcinoma growth in vitro and in vivo by swainsonine and human interferon-alpha 2. J. Natl. Cancer Inst., 81 1028-33.
- Dennis, J.W., Koch, K., Yousefi, S. and Vanderelst, I. (1990) Growth inhibition of human melanoma tumor xenografts in athymic nude mice by swainsonine. Cancer Res., 50 1867-72.
- deVries, P.J. and Dien, T.K. (1996) Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs, 52 818-36.
- Drees, M., Dengler, W.A., Roth, T., Labonte, H., Mayo, J., Malspeis, L., Grever, M., Sausville, E.A. and Fiebig, H.H. (1997) Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin. Cancer Res., 3 273-79.
- Dreyfuss, A.I., Clerk, J.R., Norris, C.M., Rossi, R.M., Lucarini, J.W., Busse, P.M., Poulin, M.D., Thornhill, L., Costello, R. and Posner, M.R. (1996) Docetaxel: an active drug for squamous cell carcinoma of the head and neck. J. Clin. Oncol., 14 1672-78.
- Einzig, A.I., Wiernik, P.H., Sasloff, J., Runowicz, C.D. and Goldberg, G.L. (1992) Phase II study and long-term follow-up of patients treated with taxol for advanced ovarian cancer. J. Clin. Oncol., 10 1748-53.
- Emerson, D.L., Besterman, J.M., Brown, H.R., Evans, M.G., Leitner, P.P., Luzzio, M.J., Shaffer, J.E., Sternbach, D.D., Uehling, D. and Vuong, A. (1995) In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogs. Cancer Res., 55 603-609.
- Endo,Y., Mitsui, K., Motizuki, M. and Tsurugi, K. (1987) The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes: the site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins. J. Biol. Chem., 262 5908-12.
- Endo, Y., Tsurugi, K. and Franz, H. (1988a) The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes: the RNA N-glycosidase activity of the protein. FEBS Lett., 231 378-80.
- Endo, Y., Tsurugi, K. and Lambert, J.M. (1988b) The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins. Biochem. Biophys. Res. Commun., 150 1032-36.
- Etzel, R. (1996) Special extract of Boswellia serrata (H 15) in the treatment of rheumatoid arthritis. Phytomedicine, 3 91-94.
- Extra, J.-M., Rousseau, F., Bruno, R., Clavel, M., Le Bail, N. and Marty, M. (1993) Phase I and pharmacokinetic study of taxotere (RP 56976; NSC 628503) given as short intravenous infusion. Cancer Res., 53 1037-42.
- Ferreras, J.M., Barbieri, L., Girbés, T., Batelli, M.G., Rojo, M.A., Arias, F.J., Rocher, M.A., Soriano, F., Mendéz, E. and Stirpe, F. (1993) Distribution and properties of major ribosome-inactivating proteins (28S rRNA N-glycosidases) of the plant Saponaria officinalis (L.) (Caryophyllaceae). Biochim. Biophys. Acta, 1216 31-42.
- Flavell, D.J., Noss, A., Pulford, K.A., Ling, N. and Flavell, S.U. (1997) Systemic therapy with 3BIT, a triple combination cocktail of anti-CD19, -CD22, and -CD38-saporin immunotoxins, is curative of human B-cell lymphoma in severe combined immunodeficient mice. Cancer Res., 57 4824-29.
- Flavin, M.T., Rizzo, J.D., Khilevich, A., Kucherenko, A., Sheinkman, A.K., Vilaychack, V., Lin, L., Chen, W., Greenwood, E.M., Pengsuparp, T., Pezzuto, J.M., Hughes, S.H., Flavin, T.M., Cibulski, M., Boulanger, W.A., Shone, R.L. and Xu, Z.-Q. (1996) Synthesis, chromatographic resolution and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers. J. Med. Chem., 39 1303-13.
- Forastiere, A.A., Neuberg, D., Taylor, S.G., DeConti, R. and Adams, G. (1993) Phase II evaluation of taxol in advanced head and neck cancer: an Eastern Cooperative Oncology Group Trial. Monogr. Natl. Cancer Inst., 15 181-84.
- Franz, H. (1986) Mistletoe lectins and their A and B chains. Oncology, 43 23-34.
- Fujimori, A., Harker, W.G., Kohlhagen, G., Hoki, Y. and Pommier, Y. (1995) Mutation at the catalytic side of topoisomerase I in CEM/C2, a human leukemia cell resistant to camptothecin. Cancer Res., 55 1339-46.
- Fumoleau, P. (1997) Efficacy and safety of docetaxel in clinical trials. Am. J. Health Syst. Pharm., 54 S19-S24.
-
Gabius, H.-J. and Gabius, S. (1998) Phytotherapeutic immunomodulation as a treatment modality in oncology: lessons from research with mistletoe, in Phytomedicines of Europe: Chemistry and Biological Activity, (eds. L.D. Lawson and R. Bauer), ACS Symposium Series 691, ACS Books, Washington, pp. 278-86.
10.1021/bk-1998-0691.ch019 Google Scholar
- Gabr, A., Kuin, A., Aalders, M., El-Gawly, H. and Smets, L.A. (1997) Cellular pharmacokinetics and cytotoxicity of camptothecin and topotecan at normal and acidic pH. Cancer Res., 57 4811-16.
- Gescher, A., Pastorino, U., Plummer, S.M. and Manson, M.M. (1998) Suppression of tumour development by substances derived from the diet-mechanisms and clinical implications. Br. J. Clin. Pharmacol., 45 1-12.
- Giovanella, B.C., Stehlin, J.S., Wall, M.E., Wani, M.C., Nicholas, A.W., Liu, L.F., Silber, R. and Potmesil, M. (1989) Highly effective DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science, 246 1046-48.
- Giovanella, B.C., Hinz, H.R., Kozielski, A.J., Stehlin, J.S., Silber, R. and Potmesil, M. (1991) Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin. Cancer Res., 51 3052-55.
- Girbes, T., Ferreras, J.M., Iglesias, R., Citores, L., DeTorre, C., Carbajales, M.L., Jimenez, P., DeBenito, F.M. and Munoz, R. (1996) Recent advances in the uses and applications of ribosome-inactivating proteins from plants. Cell. Mol. Biol., 42 461-71.
- Goldspiel, B.R. (1997) Clinical overview of the taxanes. Pharmacotherapy, 17 110S-125S.
- Goss, E.P., Reid, C.L., Bailey, D. and Dennis, J.W. (1997) Phase IB clinical trial of the oligosaccharide processing inhibitor, swainsonine, in patients with advanced malignancies. Clin. Cancer Res., 3 1077-86.
- Gottlieb, J.A. and Luce, J.K. (1972) Treatment of malignant melanoma with camptothecin (NSC-100880). Cancer Chemother. Rep., 56 103-105.
- Gridelli, C., Rossi, A., Scognamiglio, F., Guida, C., Fiore, F., Gatani, T., Scoppa, G. and Pergola, M. (1997) Carboplatin plus oral etoposide in elderly patients with advanced nonsmall-cell lung cancer: a phase II study. Anticancer Res., 17 4755-58.
- Grossbard, M.L., Freedman, A.S., Ritz, J., Coral, F., Goldmacher, V.S., Eliseo, L., Spector, N., Dear, K., Lambert, J.M., Blättler, W.A., Taylor, J.A. and Nadler, L.M. (1992) Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion. Blood, 79 576-85.
- Gruters, R.A., Neefjes, J.J., Tersmette, M., de Goede, R.E., Tulp, A., Huisman, H.G., Miedema, F. and Ploegh, H.L. (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature, 330 74-77.
- Guéritte-Voegelein, F., Guénard, D., Lavelle, F., LeGoff, M.-T., Mangatal, L. and Potier, P. (1991) Relationships between the structure of taxol analogues and their antimitotic activity. J. Med. Chem., 34 992-98.
- Guilbaud, N., KrausBerthier, L., SaintDizier, D., Rouillon, M.H., Jan, M., Burbridge, M., Visalli, M., Bisagni, E., Pierre, A. and Atassi, G. (1996) In vivo antitumor activity of S 16020-2, a new olivacine derivative. Cancer Chemother. Pharmacol., 38 513-21.
- Gupta, I., Parihar, A., Malhotra, P., Singh, G.B., Ludtke, R., Safayhi, H. and Ammon, H.P.T. (1997) Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur. J. Med. Res., 2 37-43.
- Gupta, O.P., Sharma, N. and Chand, D. (1992) A sensitive and relevant model for evaluating anti-inflammatory activity, papaya latex-induced rat paw inflammation. J. Pharmacol. Toxicol. Methods, 28 15-19.
- Ha, V., Nguyen, N.H., Tran, T.B., Bui, M.C., Nguyen, H.P., Tran, T.H., Phan, T.Q., Arnold, K. and Tran, T.H. (1997) Severe and complicated malaria treated with artemisinin, artesunate or artemether in Vietnam. Trans. R. Soc. Trop. Med. Hyg., 91 465-67.
- Hallock, Y.F., Manfredi, K.P., Dai, J.-R., Cardelina II, J.H., Gulakowski, R.J., McMahon, J.B., Schäffer, M., Stahl, M., Gulden, K.-P., Bringmann, G., Francois, G. and Boyd, M.R. (1997) Michellamines D–F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis . J. Nat. Prod., 60 677-83.
-
J.B. Harborne (ed) (1994) The Flavonoids: Advances in Research Since 1986, Chapman & Hall, London.
10.1007/978-1-4899-2911-2 Google Scholar
- Heiny, B.M., Albrecht, V. and Beuth, J. (1998) Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract. Anticancer Res., 18 583-86.
- Herman, C., Adlercreutz, T., Goldin, B.R., Gorbach, S.L., Höckerstedt, K.A.V., Watanabe, S., Hämäläinen, E.K., Markannen, M.H., Mäkela, T.H., Wähälä, K.T., Hase, T.A. and Fotsis, T. (1995) Soybean phytoestrogen intake and cancer risk. J. Nutr., 125 757S-770S.
- Hill, B.T., Whelan, R.D., Shellard, S.A., McClean, S. and Hosking, L.K. (1994) Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro . Invest. New Drugs, 12 169-82.
- Holmes, F.A., Walters, R.S., Theriault, R.L., Forman, A.D., Newton, L.K., Raber, M.N., Buzdar, A.U., Frye, D.K. and Hortobagyi, G.N. (1991) Phase II trial of taxol: an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst., 83 1797-805.
- Hsiang, Y.H., Liu, L.F., Wall, M.E., Wani, M.C., Kirschenbaum, S., Silber, R. and Potmesil, M. (1989) DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogs. Cancer Res., 49 4385-89.
- Hsiang, Y.H., Hertzberg, R., Hecht, S. and Liu, L. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem., 260 14873-78.
- Huang, M.T., Newmark, H.L. and Frenkel, K. (1997) Inhibitory effects of curcumin on tumorgenesis in mice. J. Cell Biochem., 27 26-34.
- Hutchinson, C.R. (1998) Combinatorial biosynthesis for new drug discovery. Curr. Opin. Microbiol., 1 319-29.
- Janssen, O., Scheffler, A. and Kabelitz, D. (1993) In vitro effects of mistletoe extracts and mistletoe lectins: cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Arzneim. Forsch. Drug Res., 43 1221-27.
- Janssens, D., Michiels, C., Delaive, F., Eliaers, K., Drieu, K. and Remacle, J. (1995) Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem. Pharmacol., 50 991-99.
- Jaxel, C., Kohn, K.W., Wani, M.C., Wall, M.E. and Pommier, Y. (1989) Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and for a relation to antitumor activity. Cancer Res., 49 1465-69.
- Jiang, J.B., Li, G.Q., Guo, X.B., Kong, Y.C. and Arnold, K. (1982) Antimalarial activity of mefloquine and qinghaosu. Lancet, ii 285-88.
- Kamchonwongpaisan, S., Paitayatat, S., Thebtaranonth, Y., Wilairat, P. and Yuthavong, Y. (1995) Mechanism-based development of new antimalarials: synthesis of derivatives of artemisinin attached to iron chelators. J. Med. Chem., 38 2311-16.
- Kamchonwongpaisan, S. and Meshnick, S.R. (1996) The mode of action of the antimalarial, artemisinin, and its derivatives. Gen Pharmacol., 27 587-92.
- Kamchonwongpaisan, S., McKeever, P., Hossler, P., Ziffer, H. and Meshnick, S.R. (1997) Artemisinin neurotoxicity: neuropathology in rats and mechanistic studies in vitro . Am. J. Trop. Med. Hyg., 56 7-12.
- Kashman, Y., Gustafson, K.R., Fuller, R.W., Cardellina II, J.H., McMahon, J.B., Currens, M.J., Buckheit, R.W. Jr, Hughes, S.H., Cragg, G.M. and Boyd, M.R. (1992) The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum . J. Med. Chem., 35 2735-43.
- Kattan, J., Durand, M., Droz, J.P., Mahjoubi, M., Marino, J.P. and Azab, M. (1994) Phase I study of retelliptine dihydrochloride (SR 95325 B) using a single two hour intravenous infusion schedule. Am. J. Clin. Oncol., 17 242-45.
- Kaur, G., Stettler-Stevenson, M., Sebers, S., Worland, P., Sedlacek, H., Myers, C., Czech, J., Naik, R. and Sausville, E. (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone, L86-8275. J. Natl. Cancer Inst., 84 1736-40.
- Kavanagh, J.J., Kudelka, A.P., de Leon, C.G., Tresukosol, D., Hord, M., Finnegan, M.B., Kim, E.E., Varma, D., Forman, A., Cohen, P., Edwards, C.L., Freedman, R.S. and Verschraegen, C.F. (1996) Phase II study of docetaxel in patients with epithelial ovarian carcinoma refractory to platinum. Clin. Cancer Res., 2 837-42.
- Kelloff, G.J., Boone, C.W., Crowell, J.A., Steele, V.E., Lubet, R.A., Doody, L.A., Malone, W.F., Hawk, E.T. and Sigman, C.C. (1996a) New agents for cancer chemoprevention. J. Cell Biochem., 26 1-28.
- Kelloff, G.J., Crowell, J.A., Hawk, E.T., Steele, V.E., Lubet, R.A., Boone, C.W., Covey, J.M., Doody, L.A., Omenn, G.S., Greenwald, P., Hong, W.K., Parkinson, D.R., Bargheri, D., Baxter, G.T., Blunden, M., Doeltz, M.K., Eisenhauer, K.M., Johnson, K., Knapp, G.G., Longfellow, D.G., Malone, W.F., Nayfield, S.G., Seifried, H.E., Swall, L.M. and Sigman, C.C. (1996b) Strategy and planning for chemopreventive drug development: clinical Development Plans II. J. Cell. Biochem., 26, 54-71.
- Khosla, C. (1998) Combinatorial biosynthesis: new tools for the medicinal chemist. Chemtracts, 11 1-15.
- A.D. Kinghorn and M.F. Balandrin (eds) (1993) Human Medicinal Agents from Plants, ACS Symposium Series 534, American Chemical Society, Washington, DC.
- Kirschling, R.J., Jung, S.H. and Jett, J.R. (1994) A phase II trial of taxol and GCSF in previously untreated patients with extensive stage small-cell lung cancer (SCLC). Proc. Am. Soc. Clin. Oncol., 13 (Abstract) 326.
- Klein, J., Chatterjee, S.S. and Löffelholz, K. (1997) Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba . Brain Res., 755 347-50.
- Klumpp, T.R., Goldberg, S.L., Magdalinski, A.J. and Mangan, K.F. (1997) Phase II study of high-dose cyclophosphamide, etoposide, and carboplatin (CEC) followed by autologous hematopoietic stem cell rescue in women with metastatic or high-risk non-metastatic breast cancer: multivariate analysis of factors affecting survival and engraftment. Bone Marrow Transplant., 20 273-81.
- Krausberthier, L., Guilbaud, N., Jan, M., SaintDizier, D., Rouillon, M.H., Burbridge, M.F., Pierre, A. and Atassi, G. (1997) Experimental antitumour activity of S 16020-2 in a panel of human tumours. Eur. J. Cancer, 33 1881-87.
- Kreitman, R.J. and Pastan, I. (1998) Immunotoxins for targeted cancer therapy. Adv. Drug Delivery Rev., 31 53-88.
- Kuo, S.M. (1996) Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett., 110 41-48.
- Laakmann, G., Schüle, C., Baghai, T. and Kieser, M. (1998) St. John's wort in mild-to-moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiat., 31 54-59.
- Langdon, S.P., Hendriks, H.R., Braakhuis, B.J., Pratesi, G., Berger, D.P., Fodstad, O., Fiebig, H.H. and Boven, E. (1994) Preclinical phase II studies in human tumor xenografts: a European multicenter follow-up study. Ann. Oncol., 5 415-22.
- Langer, M., Rothe, M., Eck, J., Möckel, B. and Zinke, H. (1996) A nonradioactive assay for ribosome-inactivating proteins. Anal. Biochem., 243 150-53.
- Laurent, G., Maraninchi, D., Gluckman, E., Vernant, J.P., Derocq, J.M., Gaspard, M.H., Rio, B., Michalet, M., Reiffers, J., Dreyfus, F., Casellas, P., Schneider, P., Blythman, H.E., Bouloux, C. and Jansen, F.K. (1989) Donor bone marrow treatment with T101 Fab fragment-ricin A-chain immunotoxin prevents graft-versus-host disease. Bone Marrow Transplant., 4 367-71.
- Le Bars, P.L., Katz, M.M., Berman, N., Itil, T.M., Freedman, A.M. and Schatzberg A.F. (1997) A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia: North American EGb Study Group. J. Am. Med. Assoc., 278 1327-32.
- Le Mée, S., Pierré, A., Markovits, J., Atassi, G., Jacquemin-Sablon, A. and Saucier, J.-M. (1998) S16020-2, a new highly cytotoxic antitumor olivacine derivative: DNA interaction and DNA topoisomerase II inhibition. Mol. Pharmacol., 53 213-20.
- Lenartz, D., Stoffel, B., Menzel, J. and Beuth, J. (1996) Immunoprotective activity of the galactoside-specific lectin from mistletoe after tumor destructive therapy in glioma patients. Anticancer Res., 16 3799-802.
- Leonce, S., Perez, V., Casabianca-Piegnede, M.R., Anstett, M., Bisagni, E., Pierre, A. and Atassi, G. (1996) In vitro cytotoxicity of S16020-2, a new olivacine derivative. Invest. New Drugs, 14 169-80.
- Lin, A.J., Zikry, A.B. and Kyle, D.E. (1997) Antimalarial activity of new dihydroartemisinin derivatives. 7.4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy] butyric acids. J. Med. Chem., 40 1396-400.
- Lin, B.B. (1995) High throughput screening for new drug discovery. Yaowu Shipin Fenxi, 3 233-41.
-
Lin, J.K., Chen, Y.C., Huang, Y.T. and LinShiau, S.Y. (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J. Cell. Biochem., 28-29
39-48.
10.1002/(SICI)1097-4644(1997)28/29+<39::AID-JCB5>3.0.CO;2-X CAS PubMed Web of Science® Google Scholar
- Linde, K., Ramirez, G., Mulrow, C.D., Pauls, A., Weidenhammer, W. and Melchart, D. (1996) St John's wort for depression: an overview and meta-analysis of randomised clinical trials. Br. Med. J., 313 253-58.
- Liu, L.F. (1989) DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58 351-75.
- Long, B.H., Carboni, J.M., Wasserman, A.J., Cornell, L.A., Casazza, A.M., Jensen, P.R., Lindel, T., Fenical, W. and Fairchild, C.R. (1998) Eleutherobin, a novel cytotoxic agent that induces tubulin polymerisation similar to paclitaxel (Taxol®). Cancer Res., 58 1111-15.
- Lopes-Martins, R., Catelli, M., Araujo, C., Estato, V., Cordeiro, R. and Tibirica, E. (1996) Pharmacological evidence of a role for platelet-activating factor as a modulator of vasomotor tone and blood pressure. Eur. J. Pharmacol., 308 287-94.
- Losiewicz, M.D., Carlson, B.A., Kaur, G., Sausville, E.A. and Worland, P.J. (1994) Potent inhibition of cdc2 kinase activity by the flavonoid, L86-8275. Biochem. Biophys. Res. Commun., 201 589-95.
- Lu, H.Q., Niggemann, B. and Zanker, K.S. (1996) Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three dimensional collagen matrix, by flavonoid-structured molecules. J. Cancer Res. Clin. Oncol., 122 335-42.
- Madeleine, I., Prost, S., Naudin, A., Riou, G., Lavelle, F. and Riou, J.F. (1993) Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation. Biochem. Pharmacol., 45 339-48.
- Maraganore, J.M., Joseph, M. and Bailey, M.C. (1987) Purification and characterization of trichosanthin: homology to the ricin A-chain and implications as to mechanism of abortifacient activity. J. Biol. Chem., 262 11628-33.
- Marty, M., Extra, J.M., Cottu, P.H. and Espie, M. (1997) Prospects with docetaxel in the treatment of patients with breast cancer. Eur. J. Cancer, 33 S26-S29.
- Mathe, G., Morette, C., Hallard, M. and Blanquet, D. (1997) Combinations of three or four HIV-1 virostatics applied in short sequences which differ from each other by drug rotation: preliminary results of viral loads and CD4 numbers. Biomed. Pharmacother., 51 417-26.
- McGrath, M.S., Hwang, K.M., Caldwell, S.E., Gaston, I., Luk, K.-C., Wu, P., Ng, V.L., Crowe, S., Daniels, J., Marsh, J., Deinhart, T., Lekas, P.V., Vennari, J.C., Yeung, H.-W. and Lifson, J.D. (1989) GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage. Proc. Natl. Acad. Sci. USA, 86 2844-48.
- McGuire, W.P., Rowinsky, E.K., Rosenshein, N.B., Grumbine, F.C., Ettinger, D.S., Amstrong, D.K. and Donehower, R.C. (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann. Intern. Med., 111 273-79.
- McMahon, J.B., Currens, M.J., Gulakowski, R.J., Buckheit, R.W. Jr, Lackman-Smith, C., Hallock, Y.F. and Boyd, M.R. (1995) Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms. Antimicrob. Agents Chemother., 39 484-88.
- Meshnick, S.R., Yang, Y.Z., Lima, V., Kuypers, F., Kamchonwongpaisan, S. and Yuthavong, Y. (1993) Iron-dependent free radical generation from the antimalarial agent, artemisinin (qinghaosu). Antimicrob. Agents Chemother., 37 1108-14.
- Millward, M.J., Zalcberg, J., Bishop, J.F., Webster, L.K., Zimet, A., Rischin, D., Toner, G.C., Laird, J., Cosolo, W., Urch, M., Bruno, R., Loret, C., James, R. and Blanc, C. (1997) Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small-cell lung cancer. J. Clin. Oncol., 15 750-58.
- Möckel, B., Schwarz, T., Zinke, H., Eck, J., Langer, M. and Lentzen, H. (1997) Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells: cytotoxicity, apoptosis and induction of cytokines Arzneim . Forsch. Drug Res., 47 1145-51.
- Moertel, C.G., Schutt, A.J., Reitemerer, R.G. and Hahn, R.G. (1972) Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother. Rep., 56 95-101.
- Molyneux, R.J. and James, L.F. (1981) Loco intoxication: indolizidine alkaloid of spotted locoweed. Science 216 190-91.
- Montefiori, D.C., Stewart, K., Ahearn, J.M., Zhou, J. and Zhou, J. (1993) Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21). J. Virol., 67 2699-706.
- Muggia, F.M., Creaven, P.J., Hanson, H.H., Cohen, M.C. and Selawry, O.S. (1972) Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies. Biochemistry, 56 515-21.
- Müller, W.E., Rolli, M., Schäfer, C. and Hafner, U. (1997) Effects of Hypericum extract (LI 160) in biochemical models of antidepressant. Pharmacopsychiat., 30 102-107.
- Müller, W.E., Singer, A., Wonnemann, M., Hafner, U., Rolli, M. and Schäfer, C. (1998) Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiat., 31 16-21.
- Na-Bangchang, K., Tipwangso, P., Thanavibul, A., Tan-ariya, P., Suprakob, K., Kanda, T. and Karbwang, J. (1996) Artemether-pyrimethamine in the treatment of pyrimethamine-resistant falciparum malaria. Southeast Asian J. Trop. Med. Public. Health, 27 19-23.
- Naik, R.G., Kattige, S.L., Bhat, S.V., Alreja, B., de Souza, N.J. and Rupp, R.H. (1988) An anti-inflammatory cum immunomodulatory piperidinylbenzopyranone from Dysoxylum binectariferum: isolation, structure and total synthesis. Tetrahedron, 44 2081-86.
- Nakamura, Y., Ohto, Y., Murakami, A., Osawa, T. and Ohigashi, H. (1998) Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promotor-induced reactive oxygen species generation in leukocytes in vitro and in vivo . Jpn. J. Cancer Res., 89 361-70.
- Nie, H., Cai, X., He, X., Xu, L., Ke, X., Ke, Y. and Tam, S.-C. (1998) Position 120-123, a potential active site of trichosanthin. Life Sci., 62 491-500.
- Oberpichler-Schwenk, H. and Krieglstein, J. (1992) Pharmakologische Wirkungen von Ginkgo biloba-Extrakt und -Inhaltsstoffen. Pharm. unserer Zeit, 21 224-35.
- Ohashi, M., Sugikawa, E. and Nakanishi, N. (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn. J. Cancer Res., 86 819-27.
- Pagani, O., Zucchetti, M., Sessa, C., deJong, J., D'Incalci, M., DeFusco, M., KaeserFrohlich, A., Hanauske, A. and Cavalli, F. (1996) Clinical and pharmacokinetic study of oral NK611, a new podophyllotoxin derivative. Cancer Chemother. Pharmacol., 38 541-47.
- Pendurthi, U.R., Williams, J.T. and Rao, L.V. (1997) Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin: suppression of activation of transcription factors, Egr-1, AP-1 and NF-kappa B. Arterioscler. Thromb. Vasc. Biol., 17 3406-13.
- Perego, P., Capranico, G., Supino, R. and Zunino, F. (1994) Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types. Anticancer Drugs, 5 645-49.
- Pezzuto, J.M. (1997) Plant-derived anticancer agents. Biochem. Pharmacol., 53 121-33.
- Pietri, S., Maurelli, E., Drieu, K. and Culcasi, M. (1997) Cardioprotective and antioxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J. Mol. Cell. Cardiol., 29 733-42.
- Pommier, Y. (1996) Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins. Semin. Oncol., 23 3-10.
- Pommier, Y. and Kohn, K.W. (1989) Topoisomerase II inhibition by antitumor intercalators and demethylepipodophyllotoxins, in Developments in Cancer Chemotherapy (eds. R.I. Glazer), CRC Press, Boca Raton, FL, pp. 175-96.
- Pommier, Y., Bertrand, R. and Solary, E. (1994a) Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemia HL-60 cells. Leuk. Lymph., 15 21-31.
- Pommier, Y., Leteurtre, F., Fesen, M.R., Fujimori, A., Bertrand, R., Solary, E., Kohlhagen, G. and Kohn, K.W. (1994b) Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors. Cancer Invest., 12 530-42.
- Potmesil, M. (1994) Camptothecins: from bench research to hospital wards. Cancer Res., 54 1431-39.
- Potmesil, M., Vardeman, D., Kozielski, A.J., Mendoza, J., Stehlin, J.S. and Giovanella, B.C. (1995) Growth inhibition of human cancer metastases by camptothecins in newly developed xenograft models. Cancer Res., 55 5637-41.
- Price, R.N., Nosten, F., Luxemburger, C., Kham, A., Brockman, A., Chongsuphajaisiddhi, T. and White, N.J. (1995) Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. Trans. R. Soc. Trop. Med. Hyg., 89 523-27.
- Raffa, R.B. (1998) Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals σ receptor binding. Life Sci., 62 265-70.
- Rassmann, I., Schrodel, H., Schilling, T., Zucchetti, M., KaeserFrohlich, A., Rastetter, J. and Hanauske, A.R. (1996) Clinical and pharmacokinetic phase I trial of oral dimethylaminoetoposide (NK611) administered for 21 days every 35 days. Invest. New Drugs, 14 379-86.
- Reddy, S. and Aggarwal, B.B. (1994) Curcumin is a noncompetitive and selective inhibitor of phosphorylase kinase. FEBS Lett., 341 19-22.
- Reichman, B.S., Seidman, A.D., Crown, J.P.A., Heelan, R., Hakes, T.B., Lebwohl, D.E., Gilewski, T.A., Surbone, A., Currie, V., Hudis, C.A., Yao, T.J., Klecker, R., Jamis-Dow, C., Collins, J., Quinlivan, S., Berkery, R., Toomasi, F., Canetta, R., Fisherman, J., Arbuck, S. and Norton, T. (1993) Paclitaxel and recombinant human granulocyte colony-stimulating factor as initial chemotherapy for metastatic breast cancer. J. Clin. Oncol., 11 1943-51.
- Ribereau-Gayon, G., Dumont, S., Müller, C., Jung, M.L., Poindron, P. and Anton, R. (1996) Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes. Cancer Lett., 109 33-38.
- Rose, P.G., Blessing, J.A., Mayer, A.R. and Homesley, H.D. (1998) Prolonged oral etoposide as second-line therapy for platinum-resistant and platinum-sensitive ovarian carcinoma: a gynecologic oncology group study. J. Clin. Oncol., 16 405-10.
- Rosell, R., Felip, E., Massuti, B., Gonzalez-Larriba, J.L., Benito, D., Lopez-Cabrerizo, M.P., Salamanca, O., Camps, C. and Puerto-Pica, J. (1997) A sequence-dependent paclitaxel/etoposide phase II trial in patients with non-small-cell lung cancer. Semin. Oncol., 24 S12-56-S12-60.
- Rougier, P. and Bugat, R. (1996) CPT-11 in the treatment of colorectal cancer: clinical efficacy and safety profile. Semin. Oncol., 23 34-41.
- Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R. and Ammon, H.P.T. (1992) Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther., 261 1143-46.
- Safayhi, H., Sailer, E.-R. and Ammon, H.P.T. (1995) Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-β-boswellic acid. Mol. Pharmacol., 47 1212-16.
- Safayhi, H., Rall, B., Sailer, E.R. and Ammon, H.P.T. (1997) Inhibition by boswellic acids of human leukocyte elastase. J. Pharmacol. Exp. Ther., 281 460-63.
- Sailer, E.-R., Hörnlein, R.F., Subramanian, L.R., Ammon, H.P.T. and Safayhi, H. (1996a) Preparation of novel analogues of the nonredox-type noncompetitive leukotriene biosynthesis inhibitor, AKBA. Arch. Pharm., 329 54-56.
- Sailer, E.-R., Subramanian, L.R., Rall, B., Hörnlein, R.F., Ammon, H.P.T. and Safayhi, H. (1996b) Acetyl-11-keto-β-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity. Br. J. Pharmacol., 117 615-18.
- Sasaki, K., Wada, K., Hatta, S., Ohshika, H. and Haga, M. (1997) Bilobalide, a constituent of Ginkgo biloba (L.) potentiates drug-metabolizing enzyme activities in mice: possible mechanism for anticonvulsant activity against 4-O-methylpyridoxine-induced convulsions. Res. Commun. Mol. Pathol. Pharmacol., 96 45-56.
- Schiff, P.B., Fant, J. and Horwitz, S.B. (1979) Promotion of microtubule assembly in vitro by taxol. Nature, 22 665-67.
- Scholtyssek, H., Damerau, W., Wessel, R. and Schimke, I. (1997) Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem. Biol. Interact., 106 183-90.
- Schrader, E., Meier, B. and Brattstrom, A (1998) Hypericum treatment of mild-moderate depression in a placebo-controlled study: a prospective, double-blind, randomized, placebo-controlled, multicentre study. Human Psychopharm., 13 163-69.
- Schumacher, U., Stamouli, A., Adam, E., Peddie, M. and Pfueller, U. (1995) Biochemical, histochemical and cell biological investigations on the actions of mistletoe lectins I, II and III with human breast cancer cell lines. Glycoconj. J., 12 250-57.
- Senderowicz, A.M., Headlee, D., Stinson, S., Lush, R.M., Tompkins, A., Brawley, O., Bergan, R., Figg, W.D., Smith, A. and Sausville, E.A. (1996) Phase I trial of a novel cyclin-dependent kinase inhibitor, flavopiridol, in patients with refractory neoplasms. Ann. Oncol., 7 77.
- Sharma, M.L., Bani, S. and Singh, G.B. (1989) Antiarthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int. J. Immunopharmacol., 11 647-52.
- Shu, Y.-Z. (1998) Recent natural products based drug development: a pharmaceutical industry perspective. J. Nat. Prod., 61 1053-71.
- Singh, G.B. and Atal, C.K. (1986) Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new nonsteroidal anti-inflammatory agent. Agents Actions, 18 407-12.
- Smith, S.L., Fishwick, J., McLean, W.G., Edwards, G. and Ward, S.A. (1997) Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin. Biochem. Pharmacol., 53 5-10.
- Solary, E., Bertrand, R. and Pommier, Y. (1994) Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemic HL-60 cells. Leuk. Lymph., 15 21-32.
- Soler, M.H., Stoeva, S. and Voelter, W. (1998) Complete amino acid sequence of the B-chain of mistletoe lectin I. Biochem. Biophys. Res. Commun., 246 596-601.
- South, E.H., Exon, J.H. and Hendrix, K. (1997) Dietary curcumin enhances antibody response in rats. Immunopharmacol. Immunotoxicol., 19 105-19.
- Sreejayan and Rao, M.N. (1997) Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49 105-107.
- Stein, G.M. and Berg, P.A. (1996) Evaluation of the stimulatory activity of a fermented mistletoe lectin-I free mistletoe extract on T-helper cells and monocytes in healthy individuals in vitro . Arzneim. Forsch. Drug Res., 46 635-39.
- Stein, G., Henn, W., von Laue, H. and Berg, P.I. (1998) Modulation of the cellular and humoral immune responses of tumor patients by mistletoe therapy. Eur. J. Med. Res., 3 194-202.
- Stryer, L. (1995) Biochemistry, 4th edn, W.H. Freemann and Co., New York.
- M. Suffness (ed.) (1995) Taxol® Science and Applications, CRC Press, Boca Raton, New York, London, Tokyo.
- Suffness, M. and Cordell, G.A. (1985) Antitumor alkaloids, in The Alkaloids, Vol. XXV (ed. A. Brossi), Academic Press, New York, pp. 1-369.
- Suffness, M. and Wall, M.E. (1995) Discovery and development of taxol, in Taxol® Science and Applications (ed. M. Suffness), CRC Press, Boca Raton, New York, London, Tokyo, pp. 3-25.
-
Sunkara, P.S., Bowlin, T.L., Kang, M.S., Liu, P.S., Tyms, A.S. and Sjoerdsma, A. (1989) Anti-HIV activity of castanospermine analogues. Lancet, i
1206.
10.1016/S0140-6736(89)92787-6 Google Scholar
- Supko, J.G. and Malspeis, L. (1995) Pharmakokinetics of michellamine B, a naphthylisoquinoline alkaloid with in vitro activity against immunodeficiency virus types 1 and 2, in the mouse and dog. Antimicrob. Agents Chemother., 39 9-14.
- Svejstrup, J.Q., Christiansen, K., Gromova, I.I., Andersen, A.H. and Westergaard, O. (1991) New techniques for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I: the mode of action of camptothecin at a specific recognition site. J. Mol. Biol., 222 669-78.
- Takimoto, C.H. and Arbuck, S.G. (1997) Clinical status and optimal use of topotecan. Oncology Huntingt., 11 1635-46.
- Talbot, S.J., Weiss, R.A. and Schulz, T.F. (1995) Reduced glycosylation of human cell lines increases susceptibility to CD4-independent infection by human immunodeficiency virus type 2 (LAV-2/B). J. Virol., 69 3399-406.
- Teicher, B.A., Holden, S.A., Khandakar, V. and Herman, T.S. (1993) Addition of a topoisomerase I inhibitor to trimodality therapy (cis-diamminediochloroplatinum(II)/heat/radiation) in a murine tumor. J. Cancer Res. Clin. Oncol., 119 645-51.
- Teufel-Mayer, R. and Gleitz, J. (1997) Effects of long-term administration of Hypericum extracts on the affinity and density of the central serotonergic, 5-HT1 A and 5-HT2 A, receptors. Pharmacopsychiat., 30 113-16.
- Teuscher, E. (1997) Biogene Arzneimittel, 5th edn., Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
- Thrush, G.R., Lark, L.R., Clinchy, B.C. and Vitetta, E.S. (1996) Immunotoxins: an update. Annu. Rev. Immunol., 14 49-71.
- Tran, T.H., Day, N.P., Nguyen, H.P., Nguyen, T.H., Tran, T.H., Pham, P.L., Dinh, X.S., Ly, V.C., Ha, V., Waller, D., Peto, T.E. and White, N.J. (1996) A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N. Engl. J. Med., 335 76-83.
-
Trigg, P.I. (1989) Quinghaosu (artemisinin) as an antimalarial drug, in Economic and Medicinal Plant Research (eds. H. Wagner, H. Hikino and N.R. Farnsworth), Academic Press, London, pp. 19-55.
10.1016/B978-0-12-730064-1.50006-9 Google Scholar
- Tsao, S.W., Ng, T.B. and Yeung, H.W. (1990) Toxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines. Toxicon., 28 1183-92.
- Tulsiani, D.R., Harris, T.M. and Touster, O. (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II. J. Biol. Chem., 257 7936-39.
- Uckun, F.M., Chelstrom, L.M., TuelAhlgren, L., Dibirdik, I., Irvin, J.D., Langlie, E.C. and Myers, D.E. (1998a) TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus. Antimicob. Agents Chemother., 42 383-88.
- Uckun, F.M., Narla, R.K., Zeren, T., Yanishevski, Y., Myers, D.E., Waurzyniak, B., Ek, O., Schneider, E., Messinger, Y., Chelstrom, L.M., Gunther, R. and Evans, W. (1998b) In vivo toxicity, pharmacokinetics and anticancer activity of genistein linked to recombinant human epidermal growth factor. Clin. Cancer Res., 4 1125-43.
- VanOijen, M.G.C.T. and Preijers, F.W.M.B. (1998) Rationale for the use of immunotoxins in the treatment of HIV-infected humans. J. Drug Target., 5 75-91.
- Vitetta, E.S., Fulton, R.J., May, R.D., Till, M. and Uhr, J.W. (1987) Redesigning nature's poisons to create antitumor reagents. Science, 238 1098-104.
- Vorbach, E.U., Arnoldt, K.H. and Hübner, W.D. (1997) Efficacy and tolerability of St. John's wort extract, LI 160, versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiat., 30 81-85.
- Waddick, K.G., Myers, D.E., Gunther, R., Chelstrom, L.M., Chandan-Langlie, M., Irvin, J.D., Tumer, N. and Uckun, F.M. (1995) In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation resistant human B-cell precursor leukemia cells. Blood, 86 4228-33.
- Wall, M.E. and Wani, M.C. (1995) Camptothecin and taxol: discovery to clinic. Cancer Res., 55 753-60.
- Wall, M.E., Wani, M.C., Cook, C.E., Palmer, K.H., McPhail, A.T. and Sim, G.A. (1966) Plant antitumor agents. I. The isolation and structure of camptothecin: a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata . J. Am. Chem. Soc. 88 3888-90.
- Wani, M.C., Nicholas, A.W. and Wall, M.E. (1987) Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5′ (RS)-1,5-dioxo-(5′-ethyl-5′-hydroxy-2′-H, 5′-H, 6′-H-6-oxopyrano) [3′,4′-f]-6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. J. Med. Chem., 30 2317-19.
- Wani, M.C., Ronman, P.E., Lindley, J.T. and Wall, M.E. (1980) Plant tumor agents. 18. Synthesis and biological activity of camptothecin analogs. J. Med. Chem., 23 554-60.
- Wani, M.C., Taylor, H.L., Wall, M.E., Coggon, P. and McPhail, A.T. (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia . J. Am. Chem. Soc., 93 2325-27.
- Weiner, L.M., O'Dwyer, J., Kitson, J., Comis, R.L., Frankel, A.E., Bauer, R.J., Konrad, M.S. and Groves, E.S. (1989) Phase I evaluation of an anti-breast-carcinoma monoclonal antibody 260 F9-recombinant ricin A chain immunoconjugate. Cancer Res., 49 4062-67.
- Wenzel-Seifert, K., Krautwurst, D., Lentzen, H. and Seifert, R. (1996) Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels. J. Leukoc. Biol., 60 345-55.
- Westeel, V., Murray, N., Gelmon, K., Shah, A., Sheehan, F., McKenzie, M., Wong, F., Morris, J., Grafton, C., Tsang, V., Goddard, K., Murphy, K., Parsons, C., Amy, R. and Page, R. (1998) New combination of the old drugs for elderly patients with small-cell lung cancer: a phase II study of the PAVE regimen. J. Clin. Oncol., 16 1940-47.
- White, E.L., Ross, L.J., Schmid, S.M., Kelloff, G.J., Steele, V.E. and Hill, D.L. (1998) Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea. Oncol. Rep., 5 717-22.
- Wie, N. and Sadrzadeh, S.M. (1994) Enhancement of hemin-induced membrane damage by artemisinin. Biochem. Pharmacol., 48 737-41.
- Winkler, U., Barth, S., Schnell, R., Diehl, V. and Engert, A. (1997) The emerging role of immunotoxins in leukemia and lymphoma. Ann. Oncol., 8 139-46.
- Wonnemann, M., Schäfer, C. and Müller, W.E. (1997) Effects of Hypericum extracts on glutamatergic and GABAergic receptor systems. Pharmacopsychiat., 30 237.
- Worland, P.J., Kaur, G. and Stetler-Stevenson, M. (1993) Alteration of the phosporylation state of p34 cdc2 kinase by the flavone, 186-8275, in breast carcinoma cells. Biochem. Pharmacol., 46 1831-40.
- Wu, A.M., Song, S.C., Sugii, S. and Herp, A. (1997) Differential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors. Indian J. Biochem. Biophys., 34 61-71.
- Yang, Y.Z., Little, B. and Meshnick, S.R. (1994) Alkylation of proteins by artemisinin: effects of heme, pH and drug structure. Biochem. Pharmacol., 48 569-73.
- Yoon, T.J., Yoo, Y.C., Choi, O.B., Do, M.S., Kang, T.B., Lee, S.W., Azuma, I. and Kim, J.B. (1995) Inhibitory effect of Korean mistletoe (Viscum album coloratum) extract on tumour angiogenesis and metastasis of haematogenous and non-haematogenous tumour cells in mice. Cancer Lett., 97 83-91.
- Zhang, J.-S. and Liu, W.-Y. (1992) The mechanism of action of trichosanthin on eukaryotic ribosomes-RNA N-glycosidase activity of the cytotoxin. Nucleic Acids Res., 20 1271-75.
- Zhu, L., Wu, J., Liao, H., Gao, J., Zhao, X.N. and Zhang, Z.X. (1997) Antagonistic effects of extract from leaves of Ginkgo biloba on glutamate neurotoxicity. Acta Pharm. Sin., 18 344-45.
Browse other articles of this reference work:
