Atrial Fibrillation and Atrial Flutter
Fernando Hornero
Hospital General Universitario, Valencia, Spain
Search for more papers by this authorFernando Hornero
Hospital General Universitario, Valencia, Spain
Search for more papers by this authorAbstract
Nonpharmacologic treatments of atrial fibrillation and atrial flutter potentially offer therapy, sparing patients the long-term risks of antiarrhythmic drug therapy. For patients with typical atrial flutter, contemporary catheter ablation techniques afford cure rates in excess of 85%. For patients with atrial fibrillation, surgical Maze procedure and catheter-based procedures emulating aspects of the surgical Maze technique can today offer cure rates around 75%. However, additional research and technological development is necessary to further define and refine the best effective procedure. For the present, because each therapeutic alternative carries its own unique set of risks, side effects, and benefits, patients selection remains of critical importance.
Bibliography
- 1W. B. Kannel, P. A. Wolf, E. J. Benjamin, and D. Levy, Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am. J. Cardiol. 1998; 82(8A): 2N–9N.
- 2C. D. Furberg, B. M. Psaty, T. A. Manolio, J. M. Gardin, V. E. Smith, and P. M. Rautaharju, Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). Am. J. Cardiol. 1994; 74(3): 236–241.
- 3E. J. Benjamin, D. Levy, S. M. Vaziri, R. B. D'Agostino, A. J. Belanger, and P. A. Wolf, Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 1994; 271(11): 840–844.
- 4W. A. Wattigney, G. A. Mensah, and J. B. Croft, Increased atrial fibrillation mortality: United States, 1980–1998. Am. J. Epidemiol. 2002; 155: 819–826.
- 5W. M. Feinberg, J. L. Blackshear, A. Laupacis, R. Kronmal, and R. G. Hart, Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch. Intern. Med. 1995; 155(5): 469–473.
- 6J. Jalife, J. M. Davidenko, and D. C. Michaels, A new perspective on the mechanisms of arrhythmias and sudden cardiac death: spiral waves of excitation in heart muscle. J. Cardiovasc. Electrophysiol. 1991; 2(Suppl S): 133–152.
- 7G. K. Moe and J. A. Abildskov, Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. Am. Heart J. 1959; 58: 59–70.
- 8G. K. Moe, W. C. Rheinboldt, and J. A. Abildskov, A computer model of atrial fibrillation. Am. Heart J. 1964; 64(67): 200–220.
- 9M. A. Allessie, F. I. Bonke, and F. J. Schopman, Circus movement in rabbit atrial muscle as a mechanism of tachycardia. II. The role of nonuniform recovery of excitability in the occurrence of unidirectional block, as studied with multiple microelectrodes. Circ. Res. 1976; 39(2): 168–177.
- 10J. L. Cox, T. E. Canavan, R. B. Schuessler, M. E. Cain, B. D. Lindsay, C. Stone, P. K. Smith, P. B. Corr, and J. P. Boineau, The surgical treatment of atrial fibrillation. II. Intraoperative electrophysiologic mapping and description of the electrophysiologic basis of atrial flutter and atrial fibrillation. J. Thorac. Cardiovasc. Surg. 1991; 101(3): 406–426.
- 11J. L. Cox, The surgical treatment of atrial fibrillation. IV. Surgical technique. J. Thorac. Cardiovasc. Surg. 1991; 101(4): 584–592.
- 12W. F. Garrey, The nature of fibrillary contraction of the heart: its relation to tissue mass and form. Am. J. Physiol. 1914; 33: 397–414.
- 13G. D. Byrd, S. M. Prasad, C. Ripplinger, T. R. Cassilly, R. B. Schuessler, J. P. Boineau, and R. Damiano, Importance of geometry and refractory period in sustaining atrial fibrillation. Testing the critical mass hypothesis. Circulation 2005; 112:(suppl I): I-7–I-13.
- 14E. N. Moore and J. F. Spear, Natural occurrence and experimental initiation of atrial fibrillation in different animal species. In: H. E. Kulbertus, S. B. Olsson, and M. Schlepper, eds., Atrial Fibrillation. Molndal, Suecia: AB Hassell, 1982.
- 15S. Kaseda and D. P. Zipes, Contraction-excitation feedback in the atria: a cause of changes in refractoriness. J. Am. Coll. Cardiol. 1988; 11(6): 1327–1336.
- 16S. A. Chen, C. T. Tai, W. C. Yu, Y. J. Chen, C. F. Tsai, M. H. Hsieh, C. C. Chen, V. S. Prakash, Y. A. Ding, and M. S. Chang, Right atrial focal atrial fibrillation: electrophysiologic characteristics and radiofrequency catheter ablation. J. Cardiovasc. Electrophysiol. 1999; 10(3): 328–335.
- 17M. Haissaguerre, F. I. Marcus, B. Fischer, and J. Clementy, Radiofrequency catheter ablation in unusual mechanisms of atrial fibrillation: report of three cases. J. Cardiovasc. Electrophysiol. 1994; 5(9): 743–751.
- 18P. Jais, M. Haissaguerre, D. C. Shah, S. Chouairi, L. Gencel, M. Hocini, and J. Clementy, A focal source of atrial fibrillation treated by discrete radiofrequency ablation. Circulation 1997; 95(3): 572–576.
- 19S. A. Chen, M. H. Hsieh, C. T. Tai, C. F. Tsai, V. S. Prakash, W. C. Yu, T. L. Hsu, Y. A. Ding, and M. S. Chang, Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins. Electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. Circulation 1999; 100: 1879–1886.
- 20T. Satoh and D. P. Zipes, Unequal atrial stretch in dogs increases dispersion of refractoriness conducive to developing atrial fibrillation. J. Cardiovasc. Electrophysiol. 1996; 7: 833–842.
- 21M. Haissaguerre, P. Jais, D. C. Shah, A. Takahashi, M. Hocini, G. Quiniou, S. Garrigue, A. Le Mouroux, P. Le Metayer, and J. Clementy, Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N. Engl. J. Med. 1998; 339(10): 659–666.
- 22M. Haissaguerre, L. Gencel, B. Fischer, P. Le Metayer, F. Poquet, F. I. Marcus, and J. Clementy, Successful catheter ablation of atrial fibrillation. J. Cardiovasc. Electrophysiol. 1994; 5(12): 1045–1052.
- 23D. Sherf, Studies on auricular tachycardia caused by acotine administration. Proc. Exp. Biol. Med. 1947; 64: 233–240.
10.3181/00379727-64-15754 Google Scholar
- 24D. Panescu, J. G. Whayne, S. D. Fleischman, M. S. Mirotznik, D. K. Swanson, and J. Webster, Three-dimensional finite element analysis of current density and temperature distributions during radiofrequency ablation. IEEE Trans. Biomed. Eng. 1995; 42: 879–890.
- 25E. Berjano and F. Hornero, Thermal-electrical modeling for epicardial atrial radiofrequency ablation. IEEE Trans. Biomed. Eng. 2004; 51: 1348–1357.
- 26A. V. Sahidi and P. Savard, A finite element model for radiofrequency ablation of the myocardium. IEEE Trans. Biomed. Eng. 1994; 42: 963–968.
- 27V. Jacquemet, N. Virag, Z. Ihara, L. Dang, O. Blanc, S. Zozor, J. Vesin, L. Kappenberger, and C. Henriquez, Study of unipolar electrogram morphology in a computer model of atrial fibrillation. J. Cardiovasc. Electrophysiol. 2003; 14: S172–S179.
- 28N. Virag, V. Jacquemet, C. Henriquez, S. Zozor, O. Blanc, J. Vesin, E. Pruvot, and L. Kappenberger, Study of atrial arrhythmias in a computer model based on magnetic resonance images of human atria. Chaos 2002; 12: 754–763.
- 29D. Harrild and C. Henriquez, A computer model of normal conduction in the human atria. Circ. Res. 2000; 87: e25–e36.
- 30E. Vigmond, R. Ruckdeschel, and N. Trayanova, Reentry in a morphologically realistic atrial model. J. Cardiovasc. Electrophysiol. 2001; 12: 1046–1054.
- 31J. Beamont, N. Davidenko, J. M. Davidenko, and J. Jalife, Spiral waves in two-dimensional models of ventricular muscle: formation of a stationary core. Biophys. J. 1998; 75: 1–14.
- 32I. D. McRury, D. Panescu, M. A. Mitchell, and D. E. Haines, Nonuniform heating during radiofrequency catheter ablation with long electrodes: monitoring the edge effect. Circulation 1997; 96(11): 4057–4064.
- 33M. K. Jain and P. D. Wolf, A three-dimensional finite element model of radiofrequency ablation with blood flow and its experimental validation. Ann. Biomed. Eng. 2000; 28: 1075–1084.
- 34E. Berjano and F. Hornero, What affects esophageal injury during radiofrequency ablation of the left atrium? An engineering study based on finite-element analysis. Physiol. Meas. 2005; 26: 837–848.
- 35J. Godtfredsen, Atrial fibrillation: course and prognosis. A follow-up study of 1212 cases. In: H. E. Kulbertus, S. B. Olson, and M. Schlepper, eds., Atrial Fibrillation. Stockholm, Sweden, Astra Cardiovascular, 1982.
- 36V. Fuster, I. Ryden, R. W. Asigner, D. S. Cannom, H. Crijns, R. L. Frye, J. L. Halperin, G. N. Kay, W. Klein, S. Lévy, R. L. McNamara, E. N. Prytowsky, L. S. Wann, and D. G. Wyse, ACC/AHA/ESC Guidelines for the management of patients with atrial fibrillation. JACC 2001; 38(4): 1231–1265.
- 37S. Levy, P. Novella, P. Ricard, and F. Paganelli, Paroxysmal atrial fibrillation: a need for classification. J. Cardiovasc. Electrophysiol. 1995; 6: 69–74.
- 38J. L. J. Wells, R. B. Karp, N. T. Kouchoukos, W. A. MacLean, T. N. James, and A. L. Waldo, Characterization of atrial fibrillation in man: studies following open heart surgery. Pacing Clin. Electrophysiol. 1978; 1(4): 426–438.
- 39K. T. Konings, C. J. Kirchhof, J. R. Smeets, H. J. Wellens, O. C. Penn, and M. A. Allessie, High-density mapping of electrically induced atrial fibrillation in humans. Circulation 1994; 89(4): 1665–1680.
- 40The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators, A comparison of rate control and rhythm control in patients with atrial fibrillation. N. Engl. J. Med. 2002; 347(23): 1825–1833.
- 41S. K. Huang, S. Bharati, A. R. Graham, M. Lev, F. I. Marcus, and R. C. Odell, Closed chest catheter desiccation of the atrioventricular junction using radiofrequency energy—a new method of catheter ablation. J. Am. Coll. Cardiol. 1987; 9(2): 349–358.
- 42B. D. Williamson, K. C. Man, E. Daoud, M. Niebauer, S. A. Strickberger, and F. Morady, Radiofrequency catheter modification of atrioventricular conduction to control the ventricular rate during atrial fibrillation. N. Engl. J. Med. 1994; 331(14): 910–917.
- 43G. K. Feld, R. P. Fleck, O. Fujimura, D. L. Prothro, T. D. Bahnson, and M. Ibarra, Control of rapid ventricular response by radiofrequency catheter modification of the atrioventricular node in patients with medically refractory atrial fibrillation. Circulation 1994; 90(5): 2299–2307.
- 44R. E. Kerber, External direct current cardioversion-defibrillation. In: D. P. Zipes and J. Jalife, eds., Cardiac Electrophysiology from Cell to Bedside. Philadelphia, PA: WB Saunders, 1990.
- 45S. Saksena, P. P. Tarjan, S. Bharati, B. Boveja, D. Cohen, T. Joubert, and M. Lev, Low-energy transvenous ablation of the canine atrioventricular conduction system with a suction electrode catheter. Circulation 1987; 76(2): 394–403.
- 46S. Saksena, V. S. Prakash, and M. R. Hill, Prevention of recurrent atrial fibrillation with chronic dual-site right atrial pacing. J. Am. Coll. Cardiol. 1996; 28: 687–694.
- 47P. Mabo, V. Paul, W. Jung, J. Cementy, A. Bouhour, and J. C. Daubert, Biatrial synchronous pacing for atrial arrhythmia prevention: the SYMBIAPACE study. Eur. Heart J. 1999; 20(suppl): 4.
- 48A. Elvan, H. P. Pride, J. N. Eble, and D. P. Zipes, Radiofrequency catheter ablation of the atria reduces inducibility and duration of atrial fibrillation in dogs. Circulation 1995; 91(8): 2235–2244.
- 49J. F. Swartz, G. Pellersels, J. Silvers, et al., A catheter-based curative approach to atrial fibrillation in humans. (Abstract). Circulation 1994; 18: I:335.
- 50C. Pappone, G. Oreto, F. Lamberti, G. Vicedomini, M. L. Loricchio, S. Shpun, M. Rillo, M. P. Calabro, A. Conversano, S. A. Ben-Haim, R. Cappato, and S. Chierchia, Catheter ablation of paroxysmal atrial fibrillation using a 3D mapping system. Circulation 1999; 100(11): 1203–1208.
- 51N. Doll, M. Borger, A. Fabricius, S. Sthepan, J. Gummert, F. W. Mohr, J. Hauus, H. Kottkamp, and G. Hindricks, Esophageal perforation during left atrial radiofrequency ablation: is the risk too high? J. Thorac. Cardiovasc. Surg. 2003; 125: 836–842.
- 52J. M. Williams, R. M. Ungerleider, G. K. Lofland, and J. L. Cox, Left atrial isolation: new technique for the treatment of supraventricular arrhythmia. J. Thorac. Cardiovasc. Surg. 1980; 80: 373–380.
- 53G. M. Guiraudon, C. S. Campbell, D. L. Jones, J. L. McLellan, and J. L. McDonald, Combined sino-atrial node atrio-ventricular node isolation: a surgical alternative to His ablation in patients with atrial fibrillation. Circulation 1985; 72(suppl III) (III): 220.
- 54N. M. Sankar and A. E. Farnsworth, Left atrial reduction for chronic atrial fibrillation associated with mitral valve disease. Ann. Thorac. Surg. 1998; 66(1): 254–256.
- 55F. Hornero, I. Rodriguez, J. Buendía, M. Bueno, M. J. Dalmau, S. Canovas, O. Gil, R. Garcia-Fuster, and J. A. Montero, Atrial remodeling after mitral valve surgery in patients with permanent atrial fibrillation. J. Card. Surg. 2004; 19(5): 376–382.
- 56J. L. Cox, R. B. Schuessler, D. G. Lappas, and J. P. Boineau, An 8 1/2-year clinical experience with surgery for atrial fibrillation. Ann. Surg. 1996; 224(3): 267–273.
- 57S. M. Prasad, H. S. Maniar, C. J. Camillo, R. B. Schuessler, J. P. Boineau, T. M. Sunt III, J. L. Cox, and R. Damiano, The Cox maze III procedure for atrial fibrillation: long-term efficacy in patients undergoing lone versus concomitant procedures. J. Thorac. Cardiovasc. Surg. 2003; 126(6): 1822–1828.
- 58H. T. Sie, W. P. Beukema, M. A. Ramdat, A. Elvan, J. Ennema, M. Haalebos, and H. J. Wellens, Radiofrequency modified maze in patients with atrial fibrillation undergoing concomitant cardiac surgery. J. Thorac. Cardiovasc. Surg. 2001; 112: 249–256.
- 59F. Hornero, J. A. Montero, S. Canovas, and M. Bueno, Biatrial radiofrequency ablation for atrial fibrillation: epicardial and endocardial surgical approach. Interact. Cardiovasc. Thorac. Surg. 2002; 2: 101–105.
- 60F. Hornero, I. Rodriguez, M. Bueno, J. Buendia, M. J. Dalmau, S. Canovas, O. Gil, R. Garcia-Fuster, and J. A. Montero, Surgical ablation of permanent atrial fibrillation by means of maze-radiofrequency. Mid-term results. J. Card. Surg. 2004; 9(5): 383–388.
- 61S. Grumbrecht, J. Neuzner, and H. F. Pitschner, Interrelation of tissue temperature versus flow velocity in two different kinds of temperature controlled catheter radiofrequency energy applications. J. Interv. Card. Electrophysiol. 1998; 2(2): 211–219.
- 62S. Benussi, S. Nascimbene, E. Agricola, G. Calori, S. Calvi, A. Caldarola, M. Oppizzi, V. Casati, C. Pappone, and O. Alfieri, Surgical ablation of atrial fibrillation using the epicardial radiofrequency approach: mid-term results and risk analysis. Ann. Thorac. Surg. 2002; 74: 1050–1057.
- 63J. Melo, P. Adragao, J. Neves, M. M. Ferreira, A. Timoteo, T. Santiago, R. Ribeiras, and M. Canada, Endocardial and epicardial radiofrequency ablation in the treatment of atrial fibrillation with a new intra-operative device. Eur. J. Cardiothorac. Surg. 2000; 18: 182–186.
- 64J. L. Cox and N. Ad, New surgical and catheter-based modifications of the maze procedure. Semin. Thorac. Cardiovasc. Surg. 2000; 12(1): 68–73.
- 65J. Ninet, X. Roques, R. Seitelberger, C. Deville, J. L. Pomar, J. Robin, O. Jegaden, F. Wellens, E. Wolner, G. Vedrinne, R. Gottardi, J. Orrit, M. A. Billes, D. A. Hoffmann, J. L. Cox, and G. L. Champsaur, Surgical ablation of atrial fibrillation with off-pump, epicardial, high-intensity focused ultrasound: results of a multicenter trial. J. Thorac. Cardiovasc. Surg. 2005; 30: 803–809.
- 66R. Damiano, Alternative energy sources for atrial ablation: judging the new technology. Ann. Thorac. Surg. 2003; 75(2): 329–330.
- 67S. Nath and D. E. Haines, Biophysics and pathology of catheter energy delivery systems. Prog. Cardiovasc. Dis. 1995; 37(4): 185–204.
- 68S. L. Gaynor, M. D. Diodato, S. M. Prasad, Y. Ishii, R. B. Schuessler, M. S. Bailey, N. R. Damiano, J. B. Bloch, M. R. Moon, and R. Damiano, A prospective, single-center trial of a modified Cox maze procedure with bipolar radiofrequency ablation. J. Thorac. Cardiovasc. Surg. 2004; 128(4): 535–542.
- 69M. Knaut, S. G. Spitzer, L. Karolyi, H. H. Ebert, P. Richter, S. M. Tugtekin, and S. Schuler, Intraoperative microwave ablation for curative treatment of atrial fibrillation in open heart surgery—the MICRO-STAF and MICRO-PASS pilot trial. MICROwave application in surgical treatment of atrial fibrillation. MICROwave application for the treatment of atrial fibrillation in bypass surgery. J. Thorac. Cardiovasc. Surg. 1999; 47(Suppl): 379–384.
- 70W. L. Holman, M. Ikeshita, J. M. Douglas, P. K. Smith, and J. L. Cox, Cardiac cryosurgery: effects of myocardial temperature on cryolesion size. Surgery 1983; 93(2): 268–272.
- 71W. L. Holman, M. Ikeshita, J. M. Douglas, P. K. Smith, G. K. Lofland, and J. L. Cox, Ventricular cryosurgery: short-term effects on intramural electrophysiology. Ann. Thorac. Surg. 1983; 35(4): 386–393.
- 72J. J. Bredikis and A. J. Bredikis, Surgery of tachyarrhythmia: intracardiac closed heart cryoablation. Pacing Clin. Electrophysiol. 1990; 13(12 Pt 2): 1980–1984.
- 73A. Skanes, G. Klein, A. D. Krahn, and R. Yee, Cryoablation: potentials and pitfalls. J. Cardiovasc. Electrophysiol. 2004; 15(Suppl. 1): S28–S34.
- 74E. Manasse, F. Gaita, S. Ghiselli, A. Barbone, L. Garberoglio, E. Citterio, D. Ornaghi, and R. Gallotti, Cryoablation of the left posterior atrial wall: 95 patients and 3 years of mean follow-up. Eur. J. Cardiothorac. Surg. 2003; 24(5): 731–740.
- 75M. Gillinov, G. Pettersson, and T. Rice, Esophageal injury during radiofrequency ablation of atrial fibrillation. J. Thorac. Cardiovasc. Surg. 2001; 122: 1239–1240.
- 76O. G. Anfinsen, E. Kongsgaard, A. Foerster, J. P. Amlie, and H. Aass, Bipolar radiofrequency catheter ablation creates confluent lesions at larger interelectrode spacing than does unipolar ablation from two electrodes in the porcine heart. Eur. Heart J. 1998; 19(7): 1075–1084.
- 77H. Nakagawa, W. S. Yamanashi, J. V. Pitha, M. Arruda, X. Wang, K. Ohtomo, K. J. Beckman, J. H. McClelland, R. Lazzara, and W. M. Jackman, Comparison of in vivo tissue temperature profile and lesion geometry for radiofrequency ablation with a saline-irrigated electrode versus temperature control in a canine thigh muscle preparation. Circulation 1995; 91(8): 2264–2273.
- 78M. Güden, B. Akpinar, I. Sanisoglu, E. Sagbas, and O. Bayindir, Intraoperative saline-irrigated radiofrequency modified maze procedure for atrial fibrillation. Ann. Thorac. Surg. 2002; 74: S1301–S1306.
- 79M. Knaut, S. M. Tugtekin, S. G. Spitzer, and V. Gulielmos, Combined atrial fibrillation and mitral valve surgery using microwave technology. Semin. Thorac. Cardiovasc. Surg. 2003; 14(3): 226–231.
10.1053/stcs.2002.33754 Google Scholar
- 80J. H. Levine, J. C. Merillat, M. Stern, H. F. Weisman, A. H. Kadish, E. N. Moore, J. F. Spear, J. Fonger, and T. Guarnieri, The cellular electrophysiologic changes induced by ablation: comparison between argon laser photoablation and high-energy electrical ablation. Circulation 1987; 76(1): 217–225.
- 81D. Keane and J. N. Ruskin, Linear atrial ablation with a diode laser and fiberoptic catheter. Circulation 1999; 100(14): e59–e60.
- 82T. Ohkubo, K. Okishige, Y. Goseki, T. Matsubara, K. Hiejima, and C. Ibukiyama, Experimental study of catheter ablation using ultrasound energy in canine and porcine hearts. Jap. Heart J. 1998; 39(3): 399–409.
- 83F. G. Cosio, F. Arribas, M. Lopez-Gil, and H. D. Gonzalez, Atrial flutter mapping and ablation II. Radiofrequency ablation of atrial flutter circuits. Pacing Clin. Electrophysiol. 1996; 19(6): 965–975.
- 84F. Arribas, M. Lopez-Gil, A. Nuñez, and F. Cosio, The upper link of the common atrial flutter circuit. Pacing Clin. Electrophysiol. 1997; 20: 2924–2929.
- 85M. D. Lesh, G. F. Van Hare, L. M. Epstein, A. P. Fitzpatrick, M. M. Scheinman, R. J. Lee, M. A. Kwasman, H. R. Grogin, and J. C. Griffin, Radiofrequency catheter ablation of atrial arrhythmias. Results and mechanisms. Circulation 1994; 89(3): 1074–1089.
- 86F. G. Cosio, M. Lopez-Gil, A. Goicolea, F. Arribas, and J. L. Barroso, Radiofrequency ablation of the inferior vena cava-tricuspid valve isthmus in common atrial flutter. Am. J. Cardiol. 1993; 71(8): 705–709.
- 87J. E. Olgin, J. M. Kalman, M. Chin, C. Stillson, M. Maguire, P. Ursel, and M. D. Lesh, Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance. Circulation 1997; 96(8): 2715–2721.
- 88F. Cosio, A. Goicolea, M. Lopez-Gil, F. Arribas, J. L. Barroso, and R. Chicote, Atrial endocardial mapping in the rare form of atrial flutter. Am. J. Cardiol. 1991; 66: 715–720.
- 89T. Lewis, Observations upon flutter and fibrillation: part IV. Impure flutter: theory of circus movement. Heart 1920; 7: 293–331.
- 90A. Rosenblueth and J. García Ramos, Estudios sobre el flútter y la fibrilación. II. La influencia de los obstáculos artificiales en el flútter auricular experimental. Arch. Inst. Cardiol. Mex. 1947; 17: 1–19.
- 91F. G. Cosio, F. Arribas, M. Lopez-Gil, and J. Palacios, Radiofrequency catheter ablation of atrial flutter circuits. Arch. Mal. Coeur Vaiss. 1996; 89(Spec No 1): 75–81.
- 92D. E. Pittman, T. C. Gay, I. I. Patel, and C. R. Joyner, Termination of atrial flutter and atrial tachycardia with rapid atrial stimulation. Angiology 1975; 26(11): 784–802.
- 93B. Fischer, P. Jais, D. Shah, S. Chouairi, M. Haissaguerre, S. Garrigues, F. Poquet, L. Gencel, J. Clementy, and F. I. Marcus, Radiofrequency catheter ablation of common atrial flutter in 200 patients. J. Cardiovasc. Electrophysiol. 1996; 7(12): 1225–1233.
- 94A. Natale, K. H. Newby, and E. Pisano, Prospective randomized comparison of antiarrhythmic therapy versus first-line radiofrequency ablation in patients with atrial flutter. J. Am. Coll. Cardiol. 2000; 35: 1898–1904.
- 95F. Philippon, V. J. Plumb, A. E. Epstein, and G. N. Kay, The risk of atrial fibrillation following radiofrequency catheter ablation of atrial flutter. Circulation 1995; 92(3): 430–435.