Abstract
Linkage analysis is an important initial step in localizing and identifying genes in the chromosomes that underlie many human diseases and other traits of interest. Frequently, linkage analysis proceeds by comparing the inheritance pattern of the trait and that of the genetic markers to establish linkage between the trait and marker loci. This article provides a brief overview of commonly used methods for linkage analysis, which include model-free and model-based methods for mapping qualitative- and quantitative-trait loci. Issues on the design of linkage studies are also briefly discussed.
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