Health Issues of Biopolymers: Polyhydroxybutyrate
Dr. Thomas Freier
- [email protected]
- +49-381-54345502 | Fax: +49-381-5435502
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorDr. Katrin Sternberg
- [email protected]
- +49-381-5435515 | Fax: +49-381-54345502
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorDr. Detlef Behrend
- [email protected]
- +49-381-4947605 | Fax: +49-381-4947602
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorProf. Dr. Klaus-Peter Schmitz
- [email protected]
- +49-381-4947601 | Fax: +49-381-4947602
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorDr. Thomas Freier
- [email protected]
- +49-381-54345502 | Fax: +49-381-5435502
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorDr. Katrin Sternberg
- [email protected]
- +49-381-5435515 | Fax: +49-381-54345502
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorDr. Detlef Behrend
- [email protected]
- +49-381-4947605 | Fax: +49-381-4947602
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorProf. Dr. Klaus-Peter Schmitz
- [email protected]
- +49-381-4947601 | Fax: +49-381-4947602
Institute for Biomedical Engineering University of Rostock, Ernst-Heydemann-Str. 6, Rostock, Germany, D-18055
Search for more papers by this authorAbstract
- Introduction
- Historical Outline
- Poly(3-hydroxybutyrate)
- Mechanical Properties
- Biocompatibility
- Toxicity
- Cell Culture Studies
- In vivo Studies
- Blood Compatibility
- In vitro Degradation
- In vivo Degradation
- Investigations of Clinical Applications
- Patch Materials
- Stents
- Bone Implants
- Drug Delivery Systems
- Other Applications
- Poly(4-hydroxybutyrate)
- Mechanical Properties
- Biocompatibility
- In vitro Degradation
- In vivo Degradation
- Investigations on Clinical Applications
- Excursion: Biopolymers other than PHA
- Polypeptides
- Polysaccharides
- Outlook and Perspectives
References
- Abe, H., Doi, Y., Yamamoto, Y. (1992) Controlled release of lastet, an anticancer drug, from poly(3-hydroxybutyrate) microspheres containing acylglycerols, Macromol. Rep. A29 (Suppl. 3), 229–235.
- Abe, H., Doi, Y., Kumagai, Y. (1994a) Synthesis and characterization of poly[(R,S)-3-hydroxybutyrate-β-6-hydroxyhexanoate] as a compatibilizer for a biodegradable blend of poly[(R)-3-hydroxybutyrate] and poly(6-hydroxyhexanoate), Macromolecules 27, 6012–6017.
- Abe, H., Doi, Y., Satkowski, M. M., Noda, I. (1994b) Morphology and enzymatic degradation of poly[(R)-3-hydroxybutyrate] plasticized with acylglycerols, in: Biodegradable plastics and polymers ( Y. Doi, K. Fukuda, Eds.), Amsterdam: Elsevier, 591–595.
- Abe, H., Matsubara, I., Doi, Y. (1995) Physical properties and enzymatic degradability of polymer blends of bacterial poly[(R)-hydroxybutyrate] and poly[(R,S)-3-hydroxybutyrate] stereoisomers, Macromolecules 28, 844–853.
- Akhtar, S., Pouton, C. W., Notarianni, L. J. (1991) The influence of crystalline morphology and copolymer composition on drug release from solution cast and melt-processed P(HB-HV) copolymer matrices, J. Controlled Release 17, 225–234.
- Akhtar, S., Pouton, C. W., Notarianni, L. J. (1992) Crystallization behaviour and drug release from bacterial polyhydroxyalkanoates, Polymer 33, 117–126.
- Asrar, J., Hill, J. C. (2002) Biosynthetic processes for linear polymers, J. Appl. Polym. Sci. 83, 457–483.
- Asrar, J., Pierre, J. R. (2000) Plasticized polyhydroxyalkanoate compositions and methods for their use in the production of shaped polymeric articles, US Patent 6127512.
- Atkins, T. W., Peacock, S. J. (1997) In vitro biodegradation of polyhydroxybutyrate-hydroxyvalerate microcapsules exposed to Hank's buffer, newborn calf serum, pancreatin and synthetic gastric juice, J. Microencapsul. 14, 35–49.
- Baptist, J. N. (1962) Process for preparing poly-β-hydroxybutyric acid, US Patent 3044942.
- Baptist, J. N., Ziegler, J. B. (1965) Method of making absorbable surgical sutures from poly beta hydroxy acids, US Patent 3225766.
- BCC report (2001) Biodegradable polymers, Norwalk: Business Communications Company.
-
Becher, B.,
Behrend, D.,
Schmitz, K.-P.
(2000)
Cutting of polymers with titanium saphir lasers–application stent (in German),
Biomed. Tech. 45 (Suppl. 1),
102–103.
10.1515/bmte.2000.45.s1.102 Google Scholar
-
Becher, B.,
Kiekbusch, M.,
Kramer, S.,
Schulz, U.,
Behrend, D.,
Schmitz, K.-P.
(2001)
Effect of laser processing on dilatation behaviour of balloon-expandable PHB and PLA stents (in German),
Biomed. Tech. 46 (Suppl. 1),
242–243.
10.1515/bmte.2001.46.s1.242 Google Scholar
- Behrend, D., Schmitz, K.-P. (1997) Method for the manufacture of intraluminal stents of bioresorbable polymeric material (in German), DE 19539449.
- Behrend, D., Lootz, D., Schmitz, K.-P., Schywalski, M., Labahn, D., Hartwig, S., Schaldach, M., Unverdorben, M., Vallbracht, C., Laenger, F. (1998) PHB as a bioresorbable material for intravascular stents, Am. J. Cardiol. 82 (Spec. Iss.), 4S.
- Behrend, D., Nischan, C., Kunze, C., Saß, M., Schmitz, K. P. (1999) Resorbable scaffolds for tissue engineering, Med. Biol. Eng. Comput. 37(II), 1510–1511.
- Behrend, D., Schmitz, K.-P., Haubold, A. (2000) Bioresorbable polymer materials for implant technology, Adv. Eng. Mater. 2, 123–125.
- Bibers, I., Kalnins, M. (1999) Control of biopolymer poly-β-hydroxybutyrate characteristics by γ-irradiation, Mech. Compos. Mater. 35, 169–178.
- Bissery, M.-C., Valeriote, F., Thies, C. (1984) In vitro lomustine release from small poly(β-hydroxybutyrate) and poly(d,l-lactide) microspheres, Proc. Int. Symp. Controlled Release Bioact. Mater. 11, 25–26.
- Bissery, M.-C., Valeriote, F., Thies, C. (1985) Fate and effect of CCNU-loaded microspheres made of poly(d,l)lactide (PLA) or poly-β-hydroxybutyrate (PHB) in mice, Proc. Int. Symp. Controlled Release Bioact. Mater. 12, 181–182.
- Bledzki, A. K., Gassan, J., Heyne, M. (1994) Effects of sterilization procedures on biodegradable plastics (in German), Angew. Makromol. Chem. 219, 11–26.
- Boeree, N. R., Dove, J., Cooper, J. J., Knowles, J., Hastings, G. W. (1993) Development of a degradable composite for orthopaedic use: mechanical evaluation of an hydroxyapatite-polyhydroxybutyrate composite material, Biomaterials 14, 793–796.
- Bonfield, W. (1988) Composites for bone replacement, J. Biomed. Eng. 10, 522–526.
- Bos, G. W., Scharenborg, N. M., Poot, A. A., Engbers, G. H. M., Beugeling, T., van Aken, W. G., Feijen, J. (1999) , Endothelialization of crosslinked albumin-heparin gels, Thromb. Hemost. 82, 1757–1763.
- Bowald, S. F., Johansson, E. G. (1990) A novel surgical material, EP 0349505.
- Brophy, M. R., Deasy, P. B. (1986) In vitro and in vivo studies on biodegradable polyester microparticles containing sulphamethizole, Int. J. Pharm. 29, 223–231.
- Chaput, C., Yahia, L. H., Landry, D., Rivard, C. H., Selmani, A. (1995a) Microbial PHA polymers as culture surfaces for spinal ligament fibroblasts from scoliotic patients, Biomater. Living Syst. Interact. 3, 19–27.
- Chaput, C., Assad, M., Yahia, L. H., Rivard, C. H., Selmani, A. (1995b) Cytotoxicity and hemolysis testing of microbial poly(hydroxybutyrate)-based copolymers in vitro, Biomater. Living Syst. Interact. 3, 29–38.
- Chen, L. J., Wang, M. (2002) Production and evaluation of biodegradable composites based on PHB-PHV copolymer, Biomaterials 23, 2631–2639.
- Chevallay, B., Herbage, D. (2000) Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy, Med. Biol. Eng. Comput. 38, 211–218.
- Chevallay, B., Roche, S., Herbage, D. (1998) Collagen-based biomaterials and tissue engineering, in: Biomaterials in surgery ( G. H. I. M. Walenkamp, Ed.), Stuttgart: Thieme, 3–10.
- Clarotti, G., Sledz, F., Schué, J., Ait Ben Aoumar, A., Geckeler, K. E., Orsetti, A., Paleirac, G. (1992) Modification of the biocompatible and haemocompatible properties of polymer substrates by plasma-deposited fluorocarbon coatings, Biomaterials 13, 832–840.
- Collins, A. E. M., Deasy, P. B., MacCarthy, D., Shanley, D. B. (1989) Evaluation of a controlled-release compact containing tetracycline hydrochloride bonded to tooth for the treatment of periodontal disease, Int. J. Pharm. 51, 103–114.
- Cooper, J. J., Bratt, J. S., Harrison, P., Evans, P. A. (1993) Fracture fixation device, GB 2266246.
- Coussot-Rico, P., Clarotti, G., Ait Ben Aoumar, A., Najimi, A., Sledz, J., Schué, F., Quatrefages, R. (1994) Relation between surface energy of polyhydroxyalkanoate membranes and protein adsorption on these membranes (in French), Eur. Polym. J. 30, 1327–1334.
- Dang, M.-H., Birchler, F., Wintermantel, E. (1997) Toxicity screening of biodegradable polymers. II. Evaluation of cell culture test with medium extract, Polym. Degrad. Stab. 5, 49–56.
- Davies, S., Tighe, B. (1995) Cell attachment to gel-spun polyhydroxybutyrate fibres, Polym. Prepr. 36, 103–104.
- Deasy, P. B., Collins, A. E. M., MacCarthy, D. J., Russell, R. J. (1989) Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease, J. Pharm. Pharmacol. 41, 694–699.
- Doi, Y. (1995) Microbial synthesis, physical properties, and biodegradability of polyhydroxyalkanoates, Macromol. Symp. 98, 585–599.
- Doi, Y., Kanesawa, Y., Kawaguchi, Y., Kunioka, M. (1989) Hydrolytic degradation of microbial poly(hydroxyalkanoates), Makromol. Chem. Rapid Commun. 10, 227–230.
- Doi, Y., Kanesawa, Y., Kunioka, M., Saito, T. (1990a) Biodegradation of microbial copolyesters: poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and poly(3-hydroxybutyrate-co-4-hydroxybutyrate), Macromolecules 23, 26–31.
- Doi, Y., Segawa, A., Kunioka, M. (1990b) Biosynthesis and characterization of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in Alcaligenes eutrophus, Int. J. Biol. Macromol. 12, 106–111.
- Doi, Y., Kitamura, S., Abe, H. (1995) Microbial synthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate), Macromolecules 28, 4822–4828.
- Doyle, C., Tanner, E. T., Bonfield, W. (1991) In vitro and in vivo evaluation of polyhydroxybutyrate and of polyhydroxybutyrate reinforced with hydroxyapatite, Biomaterials 12, 841–847.
-
Doyle, J. W.,
Roth, T. P.,
Smith, R. M.,
Li, Y.-Q.,
Dunn, R. M.
(1996)
Effect of calcium alginate on cellular wound healing processes modeled in vitro,
J. Biomed. Mater. Res. 32,
561–568.
10.1002/(SICI)1097-4636(199612)32:4<561::AID-JBM9>3.0.CO;2-P CAS PubMed Web of Science® Google Scholar
- Dufresne, A., Vincendon, M. (2000) Poly(3-hydroxybutyrate) and poly(3-hydroxyoctanoate) blends: morphology and mechanical behaviour, Macromolecules 33, 2998–3008.
- Dumitriu, S. (1996) Polysaccharides in medicinal applications ( S. Dumitriu, Ed.), New York: Marcel Dekker.
- Dumitriu, S. (2002) Polysaccharides as biomaterials, in: Polymeric biomaterials ( S. Dumitriu, Ed.), New York: Marcel Dekker, 1–61.
- Duvernoy, O., Malm, T., Ramström, J., Bowald, S. (1995) A biodegradable patch used as a pericardial substitute after cardiac surgery: 6- and 24-month evaluation with CT, Thorac. Cardiovasc. Surg. 43, 271–274.
- Eldridge, J. H., Hammond, C. J., Meulbroek, J. A., Staas, J. K., Gilley, R. M., Tice, T. R. (1990) Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches, J. Controlled Release 11, 205–214.
- Eldsäter, C., Albertsson, A. C., Karlsson, S. (1997) Impact of degradation mechanisms on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) during composting, Acta Polym. 48, 478–483.
- Eligio, T., Rieumont, J., Sanchez, R., Silva, J. F. S. (1999) Characterization of chemically modified poly(3-hydroxyalkanoates) and their performance as matrix for hormone release, Angew. Makromol. Chem. 270, 69–75.
- Engelberg, I., Kohn, J. (1991) Physico-mechanical properties of degradable polymers used in medical applications: a comprehensive study, Biomaterials 12, 292–304.
-
Etzrodt, D.,
Rybka, M.,
Röpke, C.,
Michalik, I.,
Behrend, D.,
Schmitz, K.-P.
(1997)
Effect of molecular weight and protein coating on surface properties of poly(β-hydroxybutyric acid) and the effect on polymer-cell interaction (in German),
Biomed. Techn. 42 (Suppl. 1),
445–446.
10.1515/bmte.1997.42.s2.445 Google Scholar
- Foster, L. J. R., Tighe, B. J. (1994) The degradation of gel-spun poly(β-hydroxybutyrate) “wool”, J. Environ. Polym. Degrad. 2, 185–194.
- Foster, L. J. R., Davies, S. M., Tighe, B. J. (2001) Centrifugally-spun polyhydroxybutyrate fibres: effect of process solvent on structure, morphology and cell response, J. Biomater. Sci. Polym. Ed. 12, 317–336.
- Franconi, F., Miceli, M., Alberti, L., Boatto, G., Coinu, R., De Montis, M. G., Tagliamonte, A. (2001) Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro, Thromb. Res. 102, 255–260.
- Fraser, H. M., Sandow, J., Seidel, H. R., Lunn, S. F. (1989) Controlled release of a GnRH agonist from a polyhydroxybutyric acid implant: reversible suppression of the menstrual cycle in the macaque, Acta Endocrinol. 121, 841–848.
- Frazza, E. J., Schmitt, E. E. (1971) A new absorbable suture, J. Biomed. Mater. Res. Biomed. Mater. Symp. 1, 43–58.
- Freier, T., Kunze, C., Nischan, C., Kramer, S., Sternberg, K., Saß, M., Hopt, U. T., Schmitz, K.-P. (2002) In vitro and in vivo degradation studies for development of a biodegradable patch based on poly(3-hydroxybutyrate), Biomaterials 23, 2649–2658.
- Fry, S. W., Fleischer, D. E. (1997) Management of a refractory benign esophageal stricture with a new biodegradable stent, Gastrointest. Endosc. 45, 179–182.
- Fukada, E., Ando, Y. (1988) Bending piezoelectricity in a microbially produced poly-β-hydroxybutyrate, Biorheology 25, 297–302.
- Gangrade, N., Price, J. C. (1992) Properties of implantable pellets prepared from a biodegradable polyester, Drug Dev. Ind. Pharm. 18, 1633–1648.
- Gassner, F., Owen, A. J. (1994) Physical properties of poly(β-hydroxybutyrate)-poly(ɛ-caprolactone) blends, Polymer 35, 2233–2236.
- Ghiya, V. P., Davé, V., Gross, R. A., McCarthy, S. P. (1995) Citrate esters as biodegradable plasticizers for poly(hydroxybutyrate-co-valerate), Polym. Prepr. 36, 420–421.
- Gogolewski, S., Jovanovic, M., Perren, S. M., Dillon, J. G., Hughes, M. K. (1993) Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA), J. Biomed. Mater. Res. 27, 1135–1148.
- Gotfredsen, K., Nimb, L., Hjorting-Hansen, E. (1994) Immediate implant placement using a biodegradable barrier, polyhydroxybutyrate-hydroxyvalerate reinforced with polyglactin 910. An experimental study in dogs, Clin. Oral Impl. Res. 5, 83–91.
- Gould, P. L., Holland, S. J., Tighe, B. J. (1987) Polymers for biodegradable medical devices IV. Hydroxybutyrate-valerate copolymers as non-disintegrating matrices for controlled-release oral dosage forms, Int. J. Pharm. 38, 231–237.
- Gürsel, I., Korkusuz, F., Türesin, F., Alaeddinoglu, N. G., Hasirci, V. (2001) In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis, Biomaterials 22, 73–80.
- Gürsel, I., Yagmurlu, F., Korkusuz, F., Hasirci, V. (2002) In vitro antibiotic release from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) rods, J. Microencapsul. 19, 153–164.
- Gurav, N., Downes, S. (1994) A qualitative in vitro evaluation of the degradable materials poly(caprolactone), poly(hydroxybutyrate) and a poly(hydroxybutyrate)-(hydroxyvalerate) copolymer, J. Mater. Sci. Mater. Med. 5, 784–787.
- Hammond, T., Liggat, J. J., Montador, J. H., Webb, A. (1994) Polyester composition, WO 94/28061.
- Hasirci, V. (2000) Biodegradable biomedical polymers. Review of degradation of and in vivo responses to polylactides and polyhydroxyalkanoates, in: Biomaterials and Bioengineering Handbook ( D. L. Wise, Ed.), New York: Marcel Dekker, 141–155.
-
Hasirci, V.,
Gürsel, I.,
Türesin, F.,
Yigitel, G.,
Korkusuz, F.,
Alaeddinoglu, G.
(1998)
Microbial polyhydroxyalkanoates as biodegradable drug release materials, in: Biomedical Science and Technology ( A. A. Hincal, H. S. Kas, Eds.), New York: Plenum Press,
183–187.
10.1007/978-1-4615-5349-6_20 Google Scholar
- Hayashi, T. (1994) Biodegradable polymers for biomedical uses, Prog. Polym. Sci. 19, 663–702.
- Hazari, A., Johansson-Ruden, G., Junemo-Bostrom, K., Ljungberg, C., Terenghi, G., Green, C., Wiberg, M. (1999a) A new resorbable wrap-around implant as an alternative nerve repair technique, J. Hand Surg. 24, 291–295.
- Hazari, A., Wiberg, M., Johanssson-Ruden, G., Green, C., Terenghi, G. (1999b) A resorbable nerve conduit as an alternative to nerve autograft in nerve gap repair, Br. J. Plast. Surg. 52, 653–657.
- Heimerl, A., Pietsch, H., Rademacher, K.-H., Schwengler, H., Winkeltau, G., Treutner, K.-H. (1989) Surgical implants (in German), EP 0336148.
- Hejazi, R., Amiji, M. (2002) Chitosan-based delivery systems: physicochemical properties and pharmaceutical applications, in: Polymeric biomaterials ( S. Dumitriu, Ed.), New York: Marcel Dekker, 213–237.
- Herold, A., Bruch, H. P., Weckbach, A., Romen, W., Schönefeld, G. (1988) Polyhydroxybutyric acid – a biodegenerable osteosynthesis material? (in German), in: Hefte zur Unfallheilkunde 200 (Pannike, A., Ed.), Berlin: Springer, 665–666.
-
Hocking, P. J.,
Marchessault, R. H.
(1994)
Biopolyesters, in: Chemistry and Technology of Biodegradable Polymers ( G. J. L. Griffin, Ed.), London: Blackie Academic & Professional,
48–96.
10.1007/978-94-011-1330-4_4 Google Scholar
- Hodde, J. (2002) Naturally occurring scaffolds for soft tissue repair and regeneration, Tissue Eng. 8, 295–308.
- Hoerstrup, S. P., Sodian, R., Daebritz, S., Wang, J., Bacha, E. A., Martin, D. P., Moran, A. M., Guleserian, K. J., Sperling, J. S., Kaushal, S., Vacanti, J. P., Schoen, F. J., Mayer, J. E., Jr. (2000) Functional living trileaflet heart valves grown in vitro, Circulation 102 (Suppl. 3), 44–49.
- Hoerstrup, S. P., Zünd, G., Sodian, R., Schnell, A. M., Grünenfelder, J., Turina, M. I. (2001) Tissue engineering of small caliber vascular grafts, Eur. J. Cardiothorac. Surg. 20 (2001), 164–169.
- Holland, S. J., Jolly, A. M., Yasin, M., Tighe, B. J. (1987) Polymers for biodegradable medical devices II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies, Biomaterials 8, 289–295.
- Holmes, P. A. (1985) Applications of PHB–a microbially produced biodegradable thermoplastic, Phys. Technol. 16, 32–36.
- Holmes, P. A. (1988) Biologically produced (R)-3-hydroxyalkanoate polymers and copolymers, in: Developments in crystalline polymers ( D. C. Bassett, Ed.), London: Elsevier, 1–65.
- Hon, D. N. S. (1996) Chitin and chitosan: medical applications, in: Polysaccharides in medicinal applications ( S. Dumitriu, Ed.), New York: Marcel Dekker, 631–651.
- Hull, E. H. (1990) Medical grade citrate ester plasticizers, in: Medical plastics today and tomorrow, Anaheim: The Society of the Plastics Industry, 1–21.
-
Ignatius, A.,
Claes, L.
(1998)
In vitro biocompatibility evaluation of poly(d,l-lactide) and poly(l-lactide-co-glycolide) (in German), in: Biodegradierbare Implantate und Materialien ( L. Claes, A. Ignatius, Eds.), Berlin: Springer,
118–129.
10.1007/978-3-642-80390-1_16 Google Scholar
- Immirzi, B., Malinconico, M., Orsello, G., Portofino, S., Volpe, M. G. (1999) Blends of biodegradable polyesters by reactive blending: preparation, characterisation and properties, J. Mater. Sci. 34, 1625–1639.
- Iordanskii, A. L., Dmitriev, E. V., Kamaev, P. P., Zaikov, G. E. (1999) Desorption of human serum albumin and human fibrinogen from the poly(3-hydroxybutyrate) surface, J. Appl. Polym. Sci. 74, 595–600.
- Ishikawa, K. (1996) Flexible member for use as a medical bag, US Patent 5480394.
- Ishikawa, K., Kawaguchi, Y., Doi, Y. (1991) Plasticization of bacterial polyester by the addition of acylglycerols and its enzymatic degradability, Kobunshi ronbunshu 48, 221–226.
- Isotalo, T., Tammela, T. L. J., Talja, M., Välimaa, T., Törmälä, P. (1998) A bioabsorbable self-expandable, self-reinforced poly-l-lactic acid urethral stent for recurrent urethral strictures: a preliminary report, J. Urol. 160, 2033–2036.
-
Jones, N. L.,
Cooper, J. J.,
Waters, R. D.,
Williams, D. F.
(2000)
Resorption profile and biological response of calcium phosphate filled plla and phb7v, in: Synthetic bioabsorbable polymers for implants ( C. M. Agrawal, J. E. Parr, S. T. Lin, Eds.), West Conshohocken: American Society for Testing and Materials,
69–82.
10.1520/STP15301S Google Scholar
- Juni, K., Nakano, M. (1987) Poly(hydroxy acids) in drug delivery, CRC Crit. Rev. Therap. Drug Carrier Syst. 3, 209–232.
- Juni, K., Nakano, M., Kubota, M. (1986) Controlled release of aclarubicin, an anticancer antibiotic, from poly-β-hydroxybutyric acid microspheres, J. Controlled Release 4, 25–32.
- Kalangos, A., Faidutti, B. (1996) Preliminary clinical results of implantation of biodegradable pericardial substitute in pediatric open heart operations, J. Thorac. Cardiovasc. Surg. 112, 1401–1402.
- Kanesawa, Y., Doi, Y. (1990) Hydrolytic degradation of microbial poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers, Makromol. Chem. Rapid Commun. 11, 679–682.
- Kassab, A. C., Xu, K., Denkbas, E. B., Dou, Y., Zhao, S., Piskin, E. (1997) Rifampicin carrying polyhydroxybutyrate microspheres as a potential chemoembolization agent, J. Biomater. Sci. Polym. Ed. 8, 947–961.
- Kassab, A. C., Piskin, E., Bilgic, S., Denkbas, E. B., Xu, K. (1999) Embolization with polyhydroxybutyrate microspheres: in vivo studies, J. Bioact. Compat. Polym. 14, 291–303.
- Kaufmann, T. (1998) Effect of plasticizer on biodegradation and biocompatibility of poly-β-hydroxybutyric acid (in German), Thesis, University of Rostock.
- Kawaguchi, T., Tsugane, A., Higashide, K., Endoh, H., Hasegawa, T., Kanno, H., Seki, T., Juni, K., Fukushima, S., Nakano, M. (1992) Control of drug release with a combination of prodrug and polymer matrix: antitumor activity and release profiles of 2′,3′-diacyl-5-fluoro-2′-deoxyuridine from poly(3-hydroxybutyrate) microspheres, J. Pharm. Sci. 81, 508–512.
- Kennedy, J. E., Notarianni, L. J., Pouton, C. W. (1987) Biocompatibility of a biodegradable polyester in rats, J. Pharm. Pharmacol. 39 (Suppl. 58P.
- Kishida, A., Yoshioka, S., Takeda, Y., Uchiyama, M. (1989) Formulation-assisted biodegradable polymer matrices, Chem. Pharm. Bull. 37, 1954–1956.
- Knowles, J. C., Hastings, G. W. (1991) In vitro degradation of a PHB/PHV copolymer and a new technique for monitoring early surface changes, Biomaterials 12, 210–214.
- Knowles, J. C., Hastings, G. W. (1993) In vitro and in vivo investigation of a range of phosphate glass-reinforced polyhydroxybutyrate-based degradable composites, J. Mater. Sci. Mater. Med. 4, 102–106.
- Knowles, J. C., Mahmud, F. A., Hastings, G. W. (1991) Piezoelectric characteristics of a polyhydroxybutyrate-based composite, Clin. Mater. 8, 155–158.
- Knowles, J. C., Hastings, G. W. (1992) In vitro degradation of a polyhydroxybutyrate/polyhydroxyvalerate copolymer, J. Mater. Sci. Mater. Med. 3, 352–358.
- König, W., Seidel, H.-R., Sandow, J. K. (1984) Pharmaceutical preparations containing regulating peptides with protracted release and procedure for their production (in German), EP 0133988.
- Koosha, F., Muller, R. H., Davis, S. S. (1989) Polyhydroxybutyrate as a drug carrier, CRC Crit. Rev. Therap. Drug Carrier Syst. 6, 117–130.
- Korkusuz, F., Korkusuz, P., Eksioglu, F., Gürsel, I., Hasirci, V. (2001) In vivo response to biodegradable controlled antibiotic release systems, J. Biomed. Mater. Res. 55, 217–228.
- Korsatko, W., Wabnegg, B., Braunegg, G., Lafferty, R. M., Strempfl, F. (1983a) Poly-d(−)-3-hydroxybutyric acid (PHB) – a biodegradable drug carrier for retarded liberation. 1. Development of parenteral matrix tablets for long term release of pharmaceuticals (in German), Pharm. Ind. 45, 525–527.
- Korsatko, W., Wabnegg, B., Tillian, H. M., Braunegg, G., Lafferty, R. M. (1983b) Poly-d(−)-3-hydroxybutyric acid (PHB) – a biodegradable drug carrier for retarded liberation. 2. The biodegradation in animals and in vitro–in vivo correlation of the liberation of pharmaceuticals from parenteral matrix retard tablets (in German), Pharm. Ind. 45, 1004–1007.
- Korsatko, W., Wabnegg, B., Tillian, H. M., Egger, G., Pfragner, R., Walser, V. (1984) Poly-d(-)-3-hydroxybutyric acid (PHB) – a biodegradable drug carrier for retarded liberation. 3. Studies on tissue compatibility of parenteral poly-d(-)-3-hydroxybutyric acid tablets in tissue culture and in vivo (in German), Pharm. Ind. 46, 952–954.
- Kostopoulos, L., Karring, T. (1994a) Guided bone regeneration in mandibular defects in rats using a bioresorbable polymer, Clin. Oral Impl. Res. 5, 66–74.
- Kostopoulos, L., Karring, T. (1994b) Augmentation of the rat mandible using guided tissue regeneration, Clin. Oral Impl. Res. 5, 75–82.
- Kramp, B., Bernd, H. E., Schumacher, W.-A., Blynow, M., Schmidt, W., Kunze, C., Behrend, D., Schmitz, K.-P. (2002) Polyhydroxybutyric acid (PHB) films and plates in defect covering of the osseus skull in a rabbit model (in German), Laryngo-Rhino-Otol. 81, 1–6.
- Kubota, M, Nakano, M., Juni, K. (1988) Mechanism of enhancement of the release rate of aclarubicin from poly-β-hydroxybutyric acid microspheres by fatty acid esters, Chem. Pharm. Bull 36, 333–337.
- Kulkarni, R. K., Pani, K. C., Neuman, C., Leonard, F. (1966) Polylactic acid for surgical implant, Arch. Surg. 93, 839–843.
- Kumagai, Y., Doi, Y. (1992a) Physical properties and biodegradability of blends of isotactic and atactic poly(3-hydroxybutyrate), Makromol. Chem. Rapid Commun. 13, 179–183.
- Kumagai, Y., Doi, Y. (1992b) Enzymatic degradation and morphologies of binary blends of microbial poly(3-hydroxybutyrate) with poly(ɛ-caprolactone), poly(1,4-butylene adipate) and poly(vinyl acetate), Polym. Degrad. Stab. 36, 241–248.
- Kunze, C., Freier, T., Kramer, S., Schmitz, K.-P. (2002) Antiinflammatory prodrugs as plasticizers for biodegradable implant materials based on poly(3-hydroxybutyrate), J. Mater. Sci. Mater. Med. 13, 1051–1055
- Kurcok, P., Kowalczuk, M., Adamus, G., Jedlinski, Z., Lenz, R. W. (1995) Degradability of poly(β-hydroxybutyrate)s. Correlation with chemical microstructure, J. Macromol. Sci. A32, 875–880.
- Labinaz, M., Zidar, J. P., Stack, R. S., Phillips, H. R. (1995) Biodegradable stents: the future of interventional cardiology? J. Intervent. Cardiol. 8, 395–405.
- Langer, R., Vacanti, J. P. (1993) Tissue Engineering, Science 260, 920–926.
- Lane, D. A., Lindahl, U. (1989) Heparin: chemical and biological properties, clinical applications ( D. A. Lane, U. Lindahl, Eds.), London: Edward Arnold.
- Lapčik, L., Jr., Lapčik, L., De Smedt, S., Demeester, J. (1998) Hyaluronan: preparation, properties, and applications, Chem. Rev. 98, 2663–2684.
- Lauto, A., Ohebshalom, M., Esposito, M., Mingin, J., Li, P. S., Felsen, D., Goldstein, M., Poppas, D. P. (2000) Self-expandable chitosan stent: design and preparation, Biomaterials 11, 1869–1874.
-
Lee, S. Y.
(1996)
Bacterial polyhydroxyalkanoates,
Biotechnol. Bioeng. 49,
1–14.
10.1002/(SICI)1097-0290(19960105)49:1<1::AID-BIT1>3.0.CO;2-P CAS PubMed Web of Science® Google Scholar
- Leenslag, J. W., Pennings, A. J., Bos, R. R. M., Rozema, F. R., Boering, G. (1987) Resorbable materials of poly(l-lactide) VII. In vivo and in vitro degradation, Biomaterials 8, 311–314.
- Leenstra, T. S., Maltha, J. C., Kuijpers-Jagtman, A. M. (1995) Biodegradation of non-porous films after submucoperiosteal implantation on the palate of Beagle dogs, J. Mater. Sci. Mater. Med. 6, 445–450.
- Lefebvre, F., Gorecki, S., Bareille, J., Amedee, L., Bordenave, L., Rabaud, M. (1992) New artificial connective matrix-like structure made of elastin solubilized peptides and collagens: elaboration, biochemical and structural properties, Biomaterials 13, 28–33.
- Li, S. M., Garreau, H., Vert, M. (1990a) Structure–property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media, part 1: poly(dl-lactic acid), J. Mater. Sci. Mater. Med. 1, 123–130.
- Li, S. M., Garreau, H., Vert, M. (1990b) Structure–property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media, Part 2 Degradation of lactide-glycolide copolymers: PLA37.5GA25 and PLA75GA25, J. Mater. Sci. Mater. Med. 1, 131–139.
- Lim, F., Sun, A. M. (1980) Microencapsulated islets as a bioartificial endocrine pancreas, Science 210, 908–910
- Lindström, L., Wigström, L., Dahlin, L.-G., Aren, C., Wranne, B. (2000) Lack of effect of synthetic pericardial substitute on right ventricular function after coronary artery bypass surgery, Scand. Cardiovasc. J. 34, 331–338.
-
Ljungberg, C.,
Johansson-Ruden, G.,
Bostrom, K. J.,
Novikov, L.,
Wiberg, M.
(1999)
Neuronal survival using a resorbable synthetic conduit as an alternative to primary nerve repair,
Microsurgery 19,
259–264.
10.1002/(SICI)1098-2752(1999)19:6<259::AID-MICR1>3.0.CO;2-Q CAS PubMed Web of Science® Google Scholar
- Löbler, M., Saß, M., Kunze, C., Schmitz, K.-P., Hopt, U. T. (2002) Biomaterial patches sutured onto the rat stomach induce a set of genes encoding pancreatic enzymes, Biomaterials 23, 577–583.
-
Lootz, D.,
Behrend, D.,
Schmitz, K.-P.,
Martin, H.,
Metzner, K.,
Schaffer, J.,
Urbaszek, W.
(1996)
Development of a method for the fabrication of resorbable stents and FEM simulation of the deformation behaviour (in German),
Biomed. Tech. 41 (Suppl. 1),
586–587.
10.1515/bmte.1996.41.s1.586 Google Scholar
-
Lootz, D.,
Kobow, M.,
Zinner, G.,
Michalik, I.,
Behrend, D.,
Schmitz, K.-P.
(1997)
Changes in the properties of polyhydroxybutyric acid due to sterilization (in German),
Biomed. Tech. 42 (Suppl. 1),
53–54.
10.1515/bmte.1997.42.s2.53 Google Scholar
- Lootz, D., Behrend, D., Kramer, S., Freier, T., Haubold, A., Benkießer, G., Schmitz, K.-P., Becher, B. (2001) Laser cutting: influence on morphological and physicochemical properties of polyhydroxybutyrate, Biomaterials 22, 2447–2452.
- Lu, B., Wang, Z. R., Yang, H. (2001) Long-acting delivery microspheres of levo-norgestrol-poly(3-hydroxybutyrate): their preparation, characterization and contraceptive tests on mice, J. Microencapsul. 18, 55–64.
- Luklinska, Z. B., Bonfield, W. (1997) Morphology and ultrastructure of the interface between hydroxyapatite-polyhydroxybutyrate composite implant and bone, J. Mater. Sci. Mater. Med. 8, 379–384.
- Maekawa, M., Pearce, R., Marchessault, R. H., Manley, R. S. J. (1999) Miscibility and tensile properties of poly(β-hydroxybutyrate)-cellulose propionate blends, Polymer 40, 1501–1505.
- Maitre, M. (1997) The gamma hydroxybutyrate signalling system and functional implication, Prog. Neurobiol. 51, 337–361.
- Malm, T., Bowald, S., Karacagil, S., Bylock, A., Busch, C. (1992a) A new biodegradable patch for closure of atrial septal defects, Scand. J. Thorac. Cardiovasc. Surg. 26, 9–14.
- Malm, T., Bowald, S., Bylock, A., Saldeen, T., Busch, C. (1992b) Regeneration of pericardial tissue on absorbable polymer patches implanted into the pericardial sac, Scand. J. Thorac. Cardiovasc. Surg. 26, 15–21.
- Malm, T., Bowald, S., Bylock, A., Busch, C. (1992c) Prevention of postoperative pericardial adhesions by closure of the pericardium with absorbable polymer patches, J. Thorac. Cardiovasc. Surg. 104, 600–607.
- Malm, T., Bowald, S., Bylock, A., Busch, C., Saldeen, T. (1994) Enlargement of the right ventricular outflow tract and the pulmonary artery with a new biodegradable patch in transannular position, Eur. Surg. Res. 26, 298–308.
-
Marois, Y.,
Zhang, Z.,
Vert, M.,
Deng, X.,
Lenz, R. W.,
Guidoin, R.
(2000)
Bacterial polyesters for biomedical applications: in vitro and in vivo assessments of sterilization, degradation rate and biocompatibility of poly(β-hydroxyoctanoate) (PHO), in: Synthetic bioabsorbable polymers for implants ( C. M. Agrawal, J. E. Parr, S. T. Lin, Eds.), West Conshohocken: American Society for Testing and Materials,
12–38.
10.1520/STP15298S Google Scholar
- Martin, D. P., Skraly, F. A., Williams, S. F. (1999) Polyhydroxyalkanoate compositions having controlled degradation rates, WO 99/32536.
- Matthew, H. W. T. (2002) Polymers for tissue engineering scaffolds, in: Polymeric biomaterials ( S. Dumitriu, Ed.), New York: Marcel Dekker, 167–186.
- McMillin, C. R. (1994) Elastomers for biomedical applications, Rubber Chem. Technol. 67, 417–446.
- Milella, E., Barra, G., Ramires, P. A., Leo, G., Aversa, P., Romito, A. (2001) Poly(l-lactide)acid/alginate composite membranes for guided tissue regeneration, J. Biomed. Mater. Res. 57, 248–257.
- Miller, N. D., Williams, D. F. (1987) On the biodegradation of poly-β-hydroxybutyrate (PHB) homopolymer and poly-β-hydroxybutyrate-hydroxyvalerate copolymers, Biomaterials 8, 129–137.
- Miralles, G., Baudoin, R., Dumas, D., Baptiste, D., Hubert, P., Stoltz, J. F., Dellacherie, E., Mainard, D., Netter, P., Payan, E. (2001) Sodium alginate sponges with or without sodium hyaluronate: in vitro engineering of cartilage, J. Biomed. Mater. Res. 57, 268–278.
- Mitomo, H., Watanabe, Y., Ishigaki, I., Saito, T. (1994) Radiation-induced degradation of poly(3-hydroxybutyrate) and the copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate), Polym. Degrad. Stab. 45, 11–17.
- Miyata, T., Taira, T., Noishiki, Y. (1992) Collagen engineering for biomaterial use, Clin. Mater. 9, 139–148.
- Mosahebi, A., Fuller, P., Wiberg, M., Terenghi, G. (2002) Effect of allogenic Schwann cell transplantation on peripheral nerve regeneration, Exp. Neurol. 173, 213–223.
- Najimi, A., Crespy, S., Mas, A., Schue, F. (1999) Evaluation of the biocompatibility of plasma treated PHB-9%HV films, Innov. Techn. Biol. Med. 20, 187–199.
- Nebe, B., Forster, C., Pommerenke, H., Fulda, G., Behrend, D., Berneweski, U., Schmitz, K.-P., Rychly, J. (2001) Structural alterations of adhesion mediating components in cells cultured on poly-β-hydroxy butyric acid, Biomaterials 22, 2425–2434.
- Nitschke, M., Schmack, G., Janke, A., Simon, F., Pleul, D., Werner, C. (2002) Low pressure plasma treatment of poly(3-hydroxybutyrate): toward tailored polymer surfaces for tissue engineering scaffolds, J. Biomed. Mater. Res. 59, 632–638.
- Nkere, U. U., Whawell, S. A., Sarraf, C. E., Schofield, J. B., O'Keefe, P. A. (1998) Pericardial substitution after cardiopulmonary bypass surgery: a trial of an absorbable patch, Thorac. Cardiovasc. Surg. 46, 77–83.
- Nobes, G. A. R., Marchessault, R. H., Maysinger, D. (1998) Polyhydroxyalkanoates: materials for delivery systems, Drug Deliv. 5, 167–177.
- Noisshiki, Y., Komatsuzaki, S. (1995) Medical material for soft tissue, JP 07275344.
- Olsen, L., Bowald, S., Busch, C., Carlsten, J., Eriksson, I. (1992) Urethral reconstruction with a new synthetic absorbable device, Scand. J. Urol. Nephrol. 26, 323–326.
- Peng, T., Gibula, P., Yao, K., Goosen, M. F. A. (1996) Role of polymers in improving the results of stenting in coronary arteries, Biomaterials 17, 685–694.
- Perego, G., Cella, G. D., Aldini, N. N., Fini, M., Giardino, R. (1994) Preparation of a new nerve guide from a poly(l-lactide-co-6-caprolactone), Biomaterials 15, 189–193.
- Pouton, C. W., Akhtar, S. (1996) Biosynthetic polyhydroxyalkanoates and their potential in drug delivery, Adv. Drug Deliv. Rev. 18, 133–162.
- Pouton, C. W., Kennedy, J. E., Notarianni, L. J., Gould, P. L. (1988a) Biocompatibility of poly β-hydroxybutyrate and related copolymers, in: International symposium on controlled release of bioactive materials: Proceedings, Lincolnshire: The Controlled Release Society, 179–180.
- Pouton, C. W., Majid, M. I. A., Notarianni, L. J. (1988b) Degradation of poly(β-hydroxybutyrate) and related copolymers, in: Proceedings of the 15th International Symposium on Controlled Release of Bioactive Materials (Heller, J., Ed.), Lincolnshire: Controlled Release Society, 181–182.
- Rabaud, M., Lefebvre, F., Martin, M. T., Aprahamian, M., Schmitthaeusler, R., Cazenave, J. P. (1987) Adduct formation between soluble fibrin monomers and elastin, Biomaterials 8, 217–222.
- Rao, K. P. (1995) Recent developments of collagen-based materials for medical applications and drug delivery systems, J. Biomater. Sci. Polym. Ed. 7, 623–645.
- Renstadt, R., Karlsson, S., Albertsson, A. C. (1999) The influence of processing induced differences in molecular structure on the biological and non-biological degradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate), P(3-HB-co-3-HV), Polym. Degrad. Stab. 63, 201–211.
- Reusch, R. N., Sparrow, A. W., Gardiner, J. (1992) Transport of poly-β-hydroxybutyrate in human plasma, Biochim. Biophys. Acta 1123, 33–40.
- Rivard, C. H., Chaput, C. J., DesRosiers, E. A., Yahia, L. H., Selmani, A. (1995) Fibroblast seeding and culture in biodegradable porous substrates, J. Appl. Biomater. 6, 65–68.
- Rivard, C. H., Chaput, C., Rhalmi, S., Selmani, A. (1996) Bioabsorbable synthetic polyesters and tissue regeneration. A study of three-dimensional proliferation of ovine chondrocytes and osteoblasts (in French), Ann. Chir. 50, 651–658
- Ropero-Miller, J. D., Goldberger, B. A. (1998) Recreational drugs. Current trends in the 90s, Clin. Lab. Med. 18, 727–746.
- Rouxhet, L., Legras, R., Schneider, Y.-J. (1998a) Interactions between a biodegradable polymer, poly(hydroxybutyrate-hydroxyvalerate), proteins and macrophages, Macromol. Symp. 130, 347–366.
- Rouxhet, L., Duhoux, F., Borecky, O., Legras, R., Schneider, Y.-J. (1998b) Adsorption of albumin, collagen, and fibronectin on the surface of poly(hydroxybutyrate-hydroxyvalerate) (PHB/HV) and of poly(ɛ-caprolactone) (PCL) films modified by an alkaline hydrolysis and of poly(ethylene terephthalate) (PET) track-etched membranes, J. Biomater. Sci. Polym. Ed. 9, 1279–1304.
- Saad, B., Ciardelli, G., Matter, S., Welti, M., Uhlschmid, G. K., Neuenschwander, P., Suter, U. W. (1996) Cell response of cultured macrophages, fibroblasts, and co-cultures of Kupffer cells and hepatocytes to particles of short-chain poly[(R)-3-hydroxybutyric acid], J. Mater. Sci. Mater. Med. 7, 56–61.
- Saad, B., Kuboki, Y., Welti, M., Uhlschmid, G. K., Neuenschwander, P., Suter, U. W. (2000) DegraPol-Foam: a degradable and highly porous polyesterurethane foam as a new substrate for bone formation, Artif. Org. 24, 939–945.
- Sadowski, B. (1988) PHB and BIOPOL as resorbable osteosynthesis material (in German), Thesis, University of Würzburg.
- Saito, T., Tomita, K., Juni, K., Ooba, K. (1991) In vivo and in vitro degradation of poly(3-hydroxybutyrate) in rat, Biomaterials 12, 309–312.
- Saß, M. (1996) Animal study on the degradation behaviour of resorbable implants (in German), Thesis, University of Rostock.
- Savenkova, L., Gercberga, Z., Nikolaeva, V., Dzene, A., Bibers, I., Kalnin, M. (2000) Mechanical properties and biodegradation characteristics of PHB-based films, Proc. Biochem. 35, 573–580.
- Schaffer, J., Voigt, H.-D., Rauchstein, K.-D., Wengemuth, K. (1995) Wound covering (in German), DE 4416357.
- Scherer, M. A., Früh, H. J., Ascherl, R., Mau, H., Siebels, W., Blümel, G. (1992) Kinetics of resorption of different suture materials depending on the implantation site and the species, in: Degradation phenomena on polymeric biomaterials ( H. Planck, M. Dauner, M. Renardy, Eds.), Berlin: Springer, 77–95.
-
Schmack, G.,
Gliesche, K.,
Nitschke, M.,
Werner, C.
(2002)
Implants based on poly(3-hydroxybutyric acid) (in German),
Biomaterialien 3,
21–25.
10.1515/BIOMAT.2002.3.1.21 Google Scholar
- Schmidt, C. E., Baier, J. M. (2000) Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering, Biomaterials 21, 2215–2231.
- Schmitt, E. E., Polistina, R. A. (1967) Surgical sutures, US Patent 3297033.
- Scholz, C. (2000) Poly(β-hydroxyalkanoates) as potential biomedical materials: an overview, in: Polymers from renewable resources: biopolyesters and biocatalysis ( C. Scholz, Ed.), Washington: American Chemical Society, 328–334.
- Schué, F., Clarotti, G., Sledz, J., Mas, A., Geckeler, K. E., Göpel, W., Orsetti, A. (1993) Possibilities offered by plasma modification and polymerization to enhance the bio- and hemocompatibility of polyester membranes, Makromol. Chem. Macromol. Symp. 73, 217–236.
- Sendil, D., Gürsel, I., Wise, D. L., Hasirci, V. (1999) Antibiotic release from biodegradable PHBV microparticles, J. Controlled Release 59, 207–217.
- SHI report (2001) Canadian biohealth technologies, Toronto: Strategic Health Innovations.
- Shum-Tim, D., Stock, U., Hrkach, J., Shinoka, T., Lien, J., Moses, M. A., Stamp, A., Taylor, G., Moran, A. M., Landis, W., Langer, R., Vacanti, J. P., Mayer, J. E., Jr. (1999) Tissue engineering of autologous aorta using a new biodegradable polymer, Ann. Thorac. Surg. 68, 2298–2305.
- Singh, D. K., Ray, A. R. (2000) Biomedical applications of chitin, chitosan, and their derivatives, J. Macromol. Sci. C40, 69–83.
- Sodian, R., Sperling, J. S., Martin, D. P., Stock, U., Mayer, J. E., Jr., Vacanti, J. P. (1999) Tissue engineering of a trileaflet heart valve–early in vitro experiences with a combined polymer, Tissue Eng. 5, 489–493.
- Sodian, R., Hoerstrup, S. P., Sperling, J. S., Martin, D. P., Daebritz, S. (2000) Evaluation of biodegradable, three-dimensional matrices for tissue engineering of heart valves, Am. Soc. Artif. Intern. Organs J. 46, 107–110.
- Sodian, R., Loebe, A., Martin, D. P., Hoerstrup, S. P., Potapov, E. V., Hausmann, H., Lueth, T., Hetzer, R. (2002) Application of stereolithography for scaffold fabrication for tissue engineering heart valves, Am. Soc. Artif. Intern. Organs J. 48, 12–16.
- Solchaga, L. A., Dennis, J. E., Goldberg, V. M., Caplan, A. I. (1999) Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage, J. Orthop. Res. 17, 205–213.
- Stange, J., Hassanein, T., Mehta, R., Mitzner, S., Bartlett, R. (2002) The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and clinical experience from 19 centers, Artif. Org. 26, 103–110.
-
Steffl, T.,
Schwarz, S.,
Bolz, A.,
Schaldach, M.
(1997)
Exposure of the bioresorbable polymer poly(β-hydroxybutyric acid) to various laser systems (in German),
Biomed. Tech. 42 (Suppl. 1),
125–126.
10.1515/bmte.1997.42.s2.125 Google Scholar
- Stock, U. A., Nagashima, M., Khalil, P. N., Nollert, G. D., Herden, T., Sperling, J. S., Moran, A., Lien, J., Martin, D. P., Schoen, F. J., Vacanti, J. P., Mayer, J. E., Jr. (2000a) Tissue-engineered valved conduits in the pulmonary circulation, J. Thorac. Cardiovasc. Surg. 119, 732–740.
- Stock, U. A., Sakamoto, T., Hatsuoka, S., Martin, D. P., Nagashima, M., Moran, A. M., Moses, M. A., Khalil, P. N., Schoen, F. J., Vacanti, J. P., Mayer, J. E., Jr. (2000b) Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding, J. Thorac. Cardiovasc. Surg. 120, 1158–1168.
- Sudesh, K., Abe, H., Doi, Y. (2000) Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters, Prog. Polym. Sci. 25, 1503–1555.
- Suh, J. K. F., Matthew, H. W. T. (2000) Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review, Biomaterials 21, 2589–2598.
- Tanguay, J. F., Zidar, J. P., Phillips, H. R., Stack, R. S. (1994) Current status of biodegradable stents, Cardiol. Clin. 12, 699–713.
- Taylor, M. S., Daniels, A. U., Andriano, K. P., Heller, J. (1994) Six bioabsorbable polymers: in vitro acute toxicity of accumulated degradation products, J. Appl. Biomater. 5, 151–157.
- Therin, M., Christel, P., Li, S., Garreau, H., Vert, M. (1992) In vivo degradation of massive poly(α-hydroxy acids): validation of in vitro findings, Biomaterials 13, 594–600.
- Tomizawa, Y., Moon, M. R., Noishiki, Y. (1994) Antiadhesive membranes for cardiac reoperations, J. Thorac. Cardiovasc. Surg. 107, 627–629.
- Tubular implant (in German) (1989) , DE 08804423.
- Türesin, F., Gürsel, I., Hasirci, V. (2001) Biodegradable polyhydroxyalkanoate implants for osteomyelitis therapy: in vitro antibiotic release, J. Biomater. Sci. Polym. Ed. 12, 195–207.
- Unverdorben, M., Schywalski, M., Labahn, D., Hartwig, S., Laenger, F., Lootz, D., Behrend, D., Schmitz, K.-P., Schaldach, M., Vallbracht, C. (1998) Polyhydroxybutyrate (PHB) biodegradable stent-experience in the rabbit, Am. J. Cardiol. 82 (Spec. Iss.), 5S.
- Unverdorben, M., Spielberger, A., Schywalski, M., Labahn, D., Hartwig, S., Schneider, M., Lootz, D., Behrend, D., Schmitz, K., Degenhardt, R., Schaldach, M., Vallbracht, C. (2002) A polyhydroxybutyrate biodegradable stent: preliminary experience in the rabbit, Cardiovasc. Intervent. Radiol. 25, 127–132.
- Vainionpää, S., Vihtonen, K., Mero, M., Pätiälä, H., Rokkanen, P., Kilpikari, J., Törmälä, P. (1986) Biodegradable fixation of rabbit osteotomies, Acta Orthopaed. Scand. 57, 237–239.
- Vainionpää, S., Rokkanen, P., Törmälä, P. (1989) Surgical applications of biodegradable polymers in human tissues, Prog. Polym. Sci. 14, 679–716.
- van der Giessen, W., Lincoff, A. M., Schwartz, R. S., van Beusekom, H. M. M., Serruys, P. W., Jr., Holmes, D. R., Ellis, S. G., Topol, E. J. (1996) Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries, Circulation 94, 1690–1697.
- Vasenius, J., Vainionpää, S., Vihtonen, K., Mero, M., Mikkola, J., Pellinen, M., Rokkanen, P., Törmälä, P. (1991) Biodegradable self-reinforced polyglycolide (SR-PGA) composite rods for fracture fixation coated with slowly biodegradable polymers–strength and strength retention in vitro and in vivo, in: Biomaterials degradation ( M. A. Barbosa, Ed.), Amsterdam: North-Holland, 393–395.
-
Wang, M.,
Wenig, J.,
Ni, J.,
Goh, C. H.,
Wang, C. X.
(2001)
Developing tricalcium phosphate/polyhydroxybutyrate composite as a new biodegradable material for clinical applications,
Key Eng. Mater. 192-195,
741–744.
10.4028/www.scientific.net/KEM.192-195.741 Google Scholar
- Webb, A., Adsetts, J. R. (1986) Wound dressings, GB 2166354.
- Williams, D. F. (1999) The Williams dictionary of biomaterials ( D. F. Williams, Ed.), Liverpool: Liverpool University Press, 40.
- Williams, S. F. (2000) Bioabsorbable, biocompatible polymers for tissue engineering, WO 00/51662.
- Williams, S. F., Martin, D. P. (2001) Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate, WO 01/19361.
- Williams, S. F., Martin, D. P. (2002) Applications of PHAs in medicine and pharmacy, in: Applications and commercial products, Polyesters, ( Y. Doi, A. Steinbüchel, Eds.), Weinheim, Germany: Wiley-VCH, 91–127.
- Williams, S. F., Martin, D. P., Horowitz, D. M., Peoples, O. P. (1999) PHA applications: addressing the price performance issue, Int. J. Biol. Macromol. 25, 111–121.
- Williams, S. F., Martin, D. P., Skraly, F. (2000) Medical devices and applications of polyhydroxyalkanoate polymers, WO 00/56376.
- Winkeltau, G. J., Treutner, K.-H., Kleimann, E., Lerch, M. M., Ger, R., Haase, G., Schumpelick, V. (1993) Protection of intestinal anastomoses by biodegradable intraluminal bypass tubes under the condition of general peritonitis: an experimental study on the CLP model in rats, Dis. Colon Rect. 36, 154–160.
-
Yagmurlu, M. F.,
Korkusuz, F.,
Gursel, I.,
Korkusuz, P.,
Ors, U.,
Hasirci, V.
(1999)
Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: in vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis,
J. Biomed. Mater. Res. 46,
494–503.
10.1002/(SICI)1097-4636(19990915)46:4<494::AID-JBM7>3.0.CO;2-E CAS PubMed Web of Science® Google Scholar
- Yasin, M., Tighe, B. J. (1992) Polymers for biodegradable medical devices VIII. Hydroxybutyrate-hydroxyvalerate copolymers: physical and degradative properties of blends with polycaprolactone, Biomaterials 13, 9–16.
- Yasin, M., Tighe, B. J. (1993) Strategies for the design of biodegradable polymer systems: manipulation of polyhydroxybutyrate-based materials, Plast. Rubber Compos. Proc. Appl. 19, 15–27.
- Yasin, M., Holland, S. J., Jolly, A. M., Tighe, B. J. (1989) Polymers for biodegradable medical devices VI. Hydroxybutyrate-hydroxyvalerate copolymers: accelerated degradation of blends with polysaccharides, Biomaterials 10, 400–412.
- Yasin, M., Holland, S. J., Tighe, B. J. (1990) Polymers for biodegradable medical devices V. Hydroxybutyrate-hydroxyvalerate copolymers: effects of polymer processing on hydrolytic degradation, Biomaterials 11, 451–454.
- Yoshioka, S., Kishida, A., Izumikawa, S., Aso, Y., Takeda, Y. (1991) Base-induced polymer hydrolysis in poly(β-hydroxybutyrate/β-hydroxyvalerate) matrices, J. Controlled Release 16, 341–348.
-
Zacchi, V.,
Soranzo, C.,
Cortivo, R.,
Radice, M.,
Brun, P.,
Abatangelo, G.
(1998)
In vitro engineering of human skin-like tissue,
J. Biomed. Mater. Res. 40,
187–194.
10.1002/(SICI)1097-4636(199805)40:2<187::AID-JBM3>3.0.CO;2-H CAS PubMed Web of Science® Google Scholar
- Zhang, L., Xiong, C., Deng, X. (1995) Biodegradable polyester blends for biomedical application, J. Appl. Polym. Sci. 56, 103–112.
- Zhang, L., Xiong, C., Deng, X. (1996) Miscibility, crystallization and morphology of poly(β-hydroxybutyrate)/poly(dl-lactide) blends, Polymer 37, 235–241.
- Zidar, J. P., Lincoff, A. M., Stack, R. S. (1994) Biodegradable stents, in: Textbook of interventional cardiology ( E. J. Topol, Ed.), Philadelphia: Saunders, 787–802.
- Zinn, M., Witholt, B., Egli, T. (2001) Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate, Adv. Drug Deliv. Syst. 53, 5–21.
-
Zinner, G.,
Behrend, D.,
Schmitz, K.-P.
(1997)
Complement activation and liberation of cytokines from monocytes as indicators of biocompatibility of polyhydroxybutyric acid (in German),
Biomed. Tech. 42 (Suppl. 1),
55–56.
10.1515/bmte.1997.42.s2.55 Google Scholar
-
Zinner, G.,
Behrend, D.,
Schmitz, K.-P.
(1998)
The hemostasis system as an indicator of hemocompatibility of implant materials (in German),
Biomed. Tech. 43 (Suppl. 1),
432–433.
10.1515/bmte.1998.43.s1.432 Google Scholar
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