Volume 44, Issue 4 pp. 616-624
Full Paper

Gradient preemphasis calibration in diffusion-weighted echo-planar imaging

Nikolaos G. Papadakis

Nikolaos G. Papadakis

Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK

Department of Physiology, University of Cambridge, Cambridge, UK

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Kay M. Martin

Kay M. Martin

Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK

Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge, Cambridge, UK

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John D. Pickard

John D. Pickard

Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK

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Laurance D. Hall

Laurance D. Hall

Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge, Cambridge, UK

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T. Adrian Carpenter

T. Adrian Carpenter

Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK

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Christopher L.-H. Huang

Corresponding Author

Christopher L.-H. Huang

Department of Physiology, University of Cambridge, Cambridge, UK

Physiological Laboratory, Downing Street, Cambridge CB2 3EG, UK===Search for more papers by this author

Abstract

This article describes a method which enables fast and objective pulse-sequence-specific preemphasis calibration, using standard pulse sequences and system hardware. The method is based on a k-space measurement technique, and has been applied to single-shot, diffusion-weighted, spin-echo, echo-planar imaging (DW-SE-EPI), which is particularly sensitive to eddy-current-induced image distortions. The efficiency of the technique was demonstrated not only by the reduction of eddy-current fields to a negligible level using full preemphasis compensation, but also by the fact that adjustment of the slow time-base alone sufficed for the practical elimination of image distortions in the DW-SE-EPI images and the subsequent diffusion tensor maps (in a phantom and a human brain). By seeking to eliminate directly the effect of eddy-current-induced phase shifts during the EPI data collection, the method is free of the complications and restrictions associated with other eddy-current correction techniques for DW-SE-EPI (such as acquisition of additional calibration scans, intense postprocessing, extensive pulse-sequence modifications), making their use redundant. Magn Reson Med 44:616–624, 2000. © 2000 Wiley-Liss, Inc.

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