Ones, Thiones, and N-Oxides: An Exercise in Imidazole Chemistry†
Stefan Laufer Prof. Dr.
Institute of Pharmacy Department of Pharmaceutical and Medicinal Chemistry Eberhard-Karls-University Tübingen Auf der Morgenstelle 8, 72076 Tübingen (Germany) Fax: (+49) 7071-29-5037
Search for more papers by this authorGerd Wagner
Institute of Pharmacy Department of Pharmaceutical and Medicinal Chemistry Eberhard-Karls-University Tübingen Auf der Morgenstelle 8, 72076 Tübingen (Germany) Fax: (+49) 7071-29-5037
Search for more papers by this authorDunja Kotschenreuther
Institute of Pharmacy Department of Pharmaceutical and Medicinal Chemistry Eberhard-Karls-University Tübingen Auf der Morgenstelle 8, 72076 Tübingen (Germany) Fax: (+49) 7071-29-5037
Search for more papers by this authorStefan Laufer Prof. Dr.
Institute of Pharmacy Department of Pharmaceutical and Medicinal Chemistry Eberhard-Karls-University Tübingen Auf der Morgenstelle 8, 72076 Tübingen (Germany) Fax: (+49) 7071-29-5037
Search for more papers by this authorGerd Wagner
Institute of Pharmacy Department of Pharmaceutical and Medicinal Chemistry Eberhard-Karls-University Tübingen Auf der Morgenstelle 8, 72076 Tübingen (Germany) Fax: (+49) 7071-29-5037
Search for more papers by this authorDunja Kotschenreuther
Institute of Pharmacy Department of Pharmaceutical and Medicinal Chemistry Eberhard-Karls-University Tübingen Auf der Morgenstelle 8, 72076 Tübingen (Germany) Fax: (+49) 7071-29-5037
Search for more papers by this authorThanks to Merckle GmbH, Blaubeuren (Germany) for financial and organizational support, Fonds der Chemischen Industrie (Germany) for financial support, Dr. W. Zimmermann for helpful discussions, and C. Greim for establishing the p38 test assay.
Graphical Abstract
Regioselective synthetic approaches to tetrasubstituted imidazoles (see picture) are reported. These highly substituted heterocycles are potent inhibitors of cytokine release and therefore interesting candidates for anti-inflammatory drugs.
Supporting Information
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