Lung cancer and environmental tobacco smoke in a non-industrial area of China†
Corresponding Author
Jay H. Lubin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS/8042, 6120 Executive Boulevard, Bethesda, Maryland 20892-7244Search for more papers by this authorShu Rong Zhang
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorCatherine Metayer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Search for more papers by this authorYing Xia
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorAlina Brenner
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Search for more papers by this authorBing Shang
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorZuoyuan Wang
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorRuth A. Kleinerman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Search for more papers by this authorCorresponding Author
Jay H. Lubin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS/8042, 6120 Executive Boulevard, Bethesda, Maryland 20892-7244Search for more papers by this authorShu Rong Zhang
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorCatherine Metayer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Search for more papers by this authorYing Xia
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorAlina Brenner
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Search for more papers by this authorBing Shang
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorZuoyuan Wang
Laboratory of Industrial Hygiene, Ministry of Public Health, China
Search for more papers by this authorRuth A. Kleinerman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Search for more papers by this authorThis article is a U.S. Government work and, as such, is in the public domain in the United States of America.
Abstract
We report results from a population-based case-control study of lung cancer and environmental tobacco smoke (ETS) among never-smokers conducted in 2 rural prefectures of China, including 200 female and 33 male lung cancer cases, and 407 female and 114 male controls, matched on age, sex and prefecture of current residence. The odds ratio (OR) for ever-exposed to ETS was 1.19 (95% CI 0.7–2.0), with a significant trend (p<0.05) with increasing exposure. ORs were 1.00, 1.04, 1.13 and 1.51 for non-exposed, <10, 10–19 and ≥20 pack-years of ETS exposure, respectively. Excess risks were limited to ETS exposures in childhood (≤18 years of age). The OR for ever-exposed to ETS in childhood, adjusting for ETS exposure in adulthood, was 1.52 (95% CI 1.1–2.2), with a significant trend (p<0.01) with increasing pack-years of childhood exposure, 1.00, 1.43, 1.81 and 2.95, respectively. After adjustment for ETS in childhood, there was no excess risk from adult ETS exposure. The OR for ever-exposed to ETS in adulthood was 0.90 (95% CI 0.–1.4). These results were not affected by adjustment for type of residential dwelling, type or amount of fuel used, perceived indoor smokiness, or measures of socioeconomic status, or omitting next-of-kin respondents. Int. J. Cancer 88:139–145, 2000. © 2000 Wiley-Liss, Inc.
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