Speckle-Tracking Echocardiography
A New Technique for Assessing Myocardial Function
Corresponding Author
Sergio Mondillo MD
Department of Cardiovascular Diseases, University of Sienna, Siena, Italy
Address correspondence to Sergio Mondillo, MD, Cardiologia Universitaria, Policlinico Le Scotte, Via Bracci, 53100 Siena, Italy.Search for more papers by this authorMaurizio Galderisi MD
Cardioangiology and Cardiac Care Unit, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Search for more papers by this authorMatteo Cameli MD
Department of Cardiovascular Diseases, University of Sienna, Siena, Italy
Search for more papers by this authorVincenzo Schiano Lomoriello MD
Cardioangiology and Cardiac Care Unit, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Search for more papers by this authorValerio Zacà MD
Department of Cardiovascular Diseases, University of Sienna, Siena, Italy
Search for more papers by this authorPiercarlo Ballo MD
Cardiologic Surgical Unit, Santa Maria Annunziata Hospital, Florence, Italy
Search for more papers by this authorAntonello D'Andrea MD
Department of Cardiology, Second University of Naples, Naples, Italy
Search for more papers by this authorDenisa Muraru MD
Institute of Cardiovascular Diseases, Bucharest, Romania
Search for more papers by this authorMariangela Losi MD
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy
Search for more papers by this authorEustachio Agricola MD
Noninvasive Cardiology Unit, San Raffaele Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
Search for more papers by this authorArcangelo D'Errico MD
Cardioangiology and Cardiac Care Unit, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Search for more papers by this authorSimona Buralli MD
Department of Clinical Medicine, University of Pisa, Pisa, Italy
Search for more papers by this authorSusanna Sciomer MD
Department of Cardiovascular, Respiratory, and Morphologic Sciences, University of Rome La Sapienza, Rome, Italy
Search for more papers by this authorStefano Nistri MD
Centro Mondialitá Sviluppo Reciproco Veneto Medica, Altavilla Vicentina, Italy
Search for more papers by this authorLuigi Badano MD
Department of Cardiology, University of Padua, Padua, Italy
Search for more papers by this authorCorresponding Author
Sergio Mondillo MD
Department of Cardiovascular Diseases, University of Sienna, Siena, Italy
Address correspondence to Sergio Mondillo, MD, Cardiologia Universitaria, Policlinico Le Scotte, Via Bracci, 53100 Siena, Italy.Search for more papers by this authorMaurizio Galderisi MD
Cardioangiology and Cardiac Care Unit, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Search for more papers by this authorMatteo Cameli MD
Department of Cardiovascular Diseases, University of Sienna, Siena, Italy
Search for more papers by this authorVincenzo Schiano Lomoriello MD
Cardioangiology and Cardiac Care Unit, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Search for more papers by this authorValerio Zacà MD
Department of Cardiovascular Diseases, University of Sienna, Siena, Italy
Search for more papers by this authorPiercarlo Ballo MD
Cardiologic Surgical Unit, Santa Maria Annunziata Hospital, Florence, Italy
Search for more papers by this authorAntonello D'Andrea MD
Department of Cardiology, Second University of Naples, Naples, Italy
Search for more papers by this authorDenisa Muraru MD
Institute of Cardiovascular Diseases, Bucharest, Romania
Search for more papers by this authorMariangela Losi MD
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy
Search for more papers by this authorEustachio Agricola MD
Noninvasive Cardiology Unit, San Raffaele Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
Search for more papers by this authorArcangelo D'Errico MD
Cardioangiology and Cardiac Care Unit, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Search for more papers by this authorSimona Buralli MD
Department of Clinical Medicine, University of Pisa, Pisa, Italy
Search for more papers by this authorSusanna Sciomer MD
Department of Cardiovascular, Respiratory, and Morphologic Sciences, University of Rome La Sapienza, Rome, Italy
Search for more papers by this authorStefano Nistri MD
Centro Mondialitá Sviluppo Reciproco Veneto Medica, Altavilla Vicentina, Italy
Search for more papers by this authorLuigi Badano MD
Department of Cardiology, University of Padua, Padua, Italy
Search for more papers by this authorAbstract
Speckle-tracking echocardiography has recently emerged as a quantitative ultrasound technique for accurately evaluating myocardial function by analyzing the motion of speckles identified on routine 2-dimensional sonograms. It provides non-Doppler, angle-independent, and objective quantification of myocardial deformation and left ventricular systolic and diastolic dynamics. By tracking the displacement of the speckles during the cardiac cycle, strain and the strain rate can be rapidly measured offline after adequate image acquisition. Data regarding the feasibility, accuracy, and clinical applications of speckle-tracking echocardiography are rapidly accumulating. This review describes the fundamental concepts of speckle-tracking echocardiography, illustrates how to obtain strain measurements using this technique, and discusses their recognized and developing clinical applications.
References
- 1Perk G, Tunick PA, Kronzon I. Non-Doppler two-dimensional strain imaging by echocardiography: from technical considerations to clinical applications. J Am Soc Echocardiogr 2007; 20: 234–243.
- 2Dandel M, Lehmkuhl H, Knosalla C, Suramelashvili N, Hetzer R. Strain and strain rate imaging by echocardiography: basic concepts and clinical applicability. Curr Cardiol Rev 2009; 5: 133–148.
- 3Blessberger H, Binder T. Non-invasive imaging: two dimensional speckle tracking echocardiography—basic principles. Heart 2010; 96: 716–722.
- 4Geyer H, Caracciolo G, Abe H, et al. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr 2010; 23: 351–369.
- 5Götte MJ, Germans T, Rüssel K, et al. Myocardial strain and torsion quantified by cardiovascular magnetic resonance tissue tagging studies in normal and impaired left ventricular function. J Am Coll Cardiol 2006; 48: 2002–2011.
- 6Buchalter MB, Weiss JL, Rogers WJ, et al. Noninvasive quantification of left ventricular rotational deformation in normal humans using magnetic resonance imaging myocardial tagging. Circulation 1990; 81: 1236–1244.
- 7Shaw SM, Fox DJ, Williams SG. The development of left ventricular torsion and its clinical relevance. Int J Cardiol 2008; 130: 319–325.
- 8Teske AJ, De Boeck BW, Melman PG, Sieswerda GT, Doevendans PA, Cramer MJ. Echocardiographic quantification of myocardial function using tissue deformation imaging, a guide to image acquisition and analysis using tissue Doppler and speckle tracking. Cardiovasc Ultrasound 2007; 5: 27.
- 9van Dalen BM, Soliman OI, Vletter WB, et al. Feasibility and reproducibility of left ventricular rotation parameters measured by speckle tracking echocardiography. Eur J Echocardiogr 2009; 10: 669–676.
- 10Vianna-Pinton R, Moreno CA, Baxter CM, Lee KS, Tsang TS, Appleton CP. Two-dimensional speckle-tracking echocardiography of the left atrium: feasibility and regional contraction and relaxation differences in normal subjects. J Am Soc Echocardiogr 2009; 22: 299–305.
- 11Sirbu C, Herbots L, D'Hooge J, et al. Feasibility of strain and strain rate imaging for the assessment of regional left atrial deformation: a study in normal subjects. Eur J Echocardiogr 2006; 7: 199–208.
- 12Okamatsu K, Takeuchi M, Nakai H, et al. Effects of aging on left atrial function assessed by two-dimensional speckle tracking echocardiography. J Am Soc Echocardiogr 2009; 22: 70–75.
- 13D'Andrea A, Caso P, Romano S, et al. Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study. Eur Heart J 2007; 28: 2738–2748.
- 14Di Salvo G, Pacileo G, Castaldi B, et al. Two-dimensional strain and atrial function: a study on patients after percutaneous closure of atrial septal defect. Eur J Echocardiogr 2009; 10: 256–259.
- 15Cameli M, Caputo M, Mondillo S, et al. Feasibility and reference values of left atrial longitudinal strain imaging by two-dimensional speckle tracking. Cardiovasc Ultrasound 2009; 7: 6.
- 16Serri K, Reant P, Lafitte M, et al. Global and regional myocardial function quantification by two-dimensional strain: application in hypertrophic cardiomyopathy. J Am Coll Cardiol 2006; 47: 1175–1181.
- 17Amundsen BH, Helle-Valle T, Edvardsen T, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol 2006; 47: 789–793.
- 18Marwick TH. Measurement of strain and strain rate by echocardiography: ready for prime time? J Am Coll Cardiol 2005; 47: 1313–1327.
- 19Heimdal A, Stoylen A, Torp H, Skjaerpe T. Real-time strain rate imaging of the left ventricle by ultrasound. J Am Soc Echocardiogr 1998; 11: 1013–1019.
- 20Brown J, Jenkins C, Marwick T. Use of myocardial strain to assess global left ventricular function: a comparison with cardiac magnetic resonance and 3-dimensional echocardiography. Am Heart J 2009; 157: 102e1–102e5.
- 21Horton KD, Meece RW, Hill JC. Assessment of the right ventricle by echocardiography: a primer for cardiac sonographers. J Am Soc Echocardiogr 2009; 22: 776–792.
- 22Saito K, Okura H, Watanabe N, et al. Comprehensive evaluation of left ventricular strain using speckle tracking echocardiography in normal adults: comparison of three-dimensional and two-dimensional approaches. J Am Soc Echocardiogr 2009; 22: 1025–1030.
- 23Notomi Y, Lysyansky P, Setser RM, et al. Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. J Am Coll Cardiol 2005; 45: 2034–2041.
- 24Takeuchi M, Nakai H, Kokumai M, Nishikage T, Otani S, Lang RM. Age-related changes in left ventricular twist assessed by two-dimensional speckle-tracking imaging. J Am Soc Echocardiogr 2006; 19: 1077–1084.
- 25Hui L, Pemberton J, Hickey E, et al. The contribution of left ventricular muscle bands to left ventricular rotation: assessment by a 2-dimensional speckle tracking method. J Am Soc Echocardiogr 2007; 20: 486–491.
- 26Buckberg G, Hoffman JIE, Mahajan A, Saleh S, Coghlan C. Cardiac mechanics revisited: the relationship of cardiac architecture to ventricular function. Circulation 2008; 118: 2571–2587.
- 27Sengupta PP, Khandheria BK, Korinek J, et al. Left ventricular isovolumic flow sequence during sinus and paced rhythms: new insights from use of high-resolution Doppler and ultrasonic digital particle imaging velocimetry. J Am Coll Cardiol 2007; 49: 899–908.
- 28van Dalen BM, Soliman OI, Vletter WB, ten Cate FJ, Geleijnse ML. Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography. Am J Physiol Heart Circ Physiol 2008; 295: H1705–H1711.
- 29Rüssel IK, Götte MJ, Bronzwaer JG, Knaapen P, Paulus WJ, van Rossum AC. Left ventricular torsion: an expanding role in the analysis of myocardial dysfunction. JACC Cardiovasc Imaging 2009; 2: 648–655.
- 30Takeuchi M, Otsuji Y, Lang RM. Evaluation of left ventricular function using left ventricular twist and torsion parameters. Curr Cardiol Rep 2009; 11: 225–230.
- 31Notomi Y, Popovic ZB, Yamada H, et al. Ventricular untwisting: a temporal link between left ventricular relaxation and suction. Am J Physiol Heart Circ Physiol 2008; 294: H505–H513.
- 32Esch BT, Warburton DE. Left ventricular torsion and recoil: implications for exercise performance and cardiovascular disease. J Appl Physiol 2009; 106: 362–369.
- 33Bertini M, Mollema SA, Delgado V, et al. Impact of time to reperfusion after acute myocardial infarction on myocardial damage assessed by left ventricular longitudinal strain. Am J Cardiol 2009; 104: 480–485.
- 34Choi JO, Shin DH, Cho SW, et al. Effect of preload on left ventricular longitudinal strain by 2D speckle tracking. Echocardiography 2008; 25: 873–879.
- 35Edvardsen T, Helle-Valle T, Smiseth OA. Systolic dysfunction in heart failure with normal ejection fraction: speckle-tracking echocardiography. Prog Cardiovasc Dis 2006; 49: 207–214.
- 36de Simone G, Devereux RB, Roman MJ, et al. Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol 1994; 23: 1444–1451.
- 37Wang J, Khoury DS, Yue Y, Torre-Amione G, Nagueh SF. Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. Eur Heart J 2008; 29: 1283–1289.
- 38Kang SJ, Lim HS, Choi BJ, et al. Longitudinal strain and torsion assessed by two-dimensional speckle tracking correlate with the serum level of tissue inhibitor of matrix metalloproteinase-1, a marker of myocardial fibrosis, in patients with hypertension. J Am Soc Echocardiogr 2008; 21: 907–911.
- 39Nakai H, Takeuchi M, Nishikage T, Lang RM, Otsuji Y. Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration. Eur J Echocardiogr 2009; 10: 926–932.
- 40Ng AC, Delgado V, Bertini M, et al. Findings from left ventricular strain and strain rate imaging in asymptomatic patients with type 2 diabetes mellitus. Am J Cardiol 2009; 104: 1398–1401.
- 41Fang ZY, Yuda S, Anderson V, Short L, Case C, Marwick TH. Echocardiographic detection of early diabetic myocardial disease. J Am Coll Cardiol 2003; 41: 611–617.
- 42Choi JO, Cho SW, Song YB, et al. Longitudinal 2D strain at rest predicts the presence of left main and three vessel coronary artery disease in patients without regional wall motion abnormality. Eur J Echocardiogr 2009; 10: 695–701.
- 43Sjøli B, Ørn S, Grenne B, Ihlen H, Edvardsen T, Brunvand H. Diagnostic capability and reproducibility of strain by Doppler and by speckle tracking in patients with acute myocardial infarction. JACC Cardiovasc Imaging 2009; 2: 24–33.
- 44Park YH, Kang SJ, Song JK, et al. Prognostic value of longitudinal strain after primary reperfusion therapy in patients with anterior-wall acute myocardial infarction. J Am Soc Echocardiogr 2008; 21: 262–267.
- 45Becker M, Lenzen A, Ocklenburg C, et al. Myocardial deformation imaging based on ultrasonic pixel tracking to identify reversible myocardial dysfunction. J Am Coll Cardiol 2008; 51: 1473–1481.
- 46Roes SD, Mollema SA, Lamb HJ, van der Wall EE, de Roos A, Bax JJ. Validation of echocardiographic two-dimensional speckle tracking longitudinal strain imaging for viability assessment in patients with chronic ischemic left ventricular dysfunction and comparison with contrast-enhanced magnetic resonance imaging. Am J Cardiol 2009; 104: 312–317.
- 47Voigt JU, Nixdorff U, Bogdan R, et al. Comparison of deformation imaging and velocity imaging for detecting regional inducible ischaemia during dobutamine stress echocardiography. Eur Heart J 2004; 25: 1517–1525.
- 48Moonen M, Lancellotti P, Zacharakis D, Pierard L. The value of 2D strain imaging during stress testing. Echocardiography 2009; 26: 307–314.
- 49Lancellotti P, Cosyns B, Zacharakis D, et al. Importance of left ventricular longitudinal function and functional reserve in patients with degenerative mitral regurgitation: assessment by two-dimensional speckle tracking. J Am Soc Echocardiogr 2008; 21: 1331–1336.
- 50Becker M, Kramann R, Dohmen G, et al. Impact of left ventricular loading conditions on myocardial deformation parameters: analysis of early and late changes of myocardial deformation parameters after aortic valve replacement. J Am Soc Echocardiogr 2007; 20: 681–689.
- 51Kosmala W, Plaksej R, Strotmann JM, et al. Progression of left ventricular functional abnormalities in hypertensive patients with heart failure: an ultrasonic two-dimensional speckle tracking study. J Am Soc Echocardiogr 2008; 21: 1309–1317.
- 52Liu YW, Tsai WC, Su CT, Lin CC, Chen JH. Evidence of left ventricular systolic dysfunction detected by automated function imaging in patients with heart failure and preserved left ventricular ejection fraction. J Card Fail 2009; 15: 782–789.
- 53Park SJ, Miyazaki C, Bruce CJ, Ommen S, Miller FA, Oh JK. Left ventricular torsion by two-dimensional speckle tracking echocardiography in patients with diastolic dysfunction and normal ejection fraction. J Am Soc Echocardiogr 2008; 21: 1129–1137.
- 54Wang J, Khoury DS, Yue Y, Torre-Amione G, Nagueh SF. Left ventricular untwisting rate by speckle tracking echocardiography. Circulation 2007; 116: 2580–2586.
- 55Cho GY, Marwick TH, Kim HS, Kim MK, Hong KS, Oh DJ. Global 2-dimensional strain as a new prognosticator in patients with heart failure. J Am Coll Cardiol 2009; 54: 618–624.
- 56Stanton T, Leano R, Marwick TH. Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring. Circ Cardiovasc Imaging 2009; 2: 356–364.
- 57Mele D, Toselli T, Dal Monte A, Guardigli G, Ceconi C, Ferrari R. Beyond dyssynchrony: what are the factors determining the response to cardiac resynchronization therapy [in Italian]? G Ital Cardiol (Rome) 2008; 9: 320–337.
- 58Chung ES, Leon AR, Tavazzi L, et al. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation 2008; 117: 2608–2616.
- 59Conca C, Faletra FF, Miyazaki C, et al. Echocardiographic parameters of mechanical synchrony in healthy individuals. Am J Cardiol 2009; 103: 136–142.
- 60Shi H, Shu X, Wang F, et al. Longitudinal two-dimensional strain rate imaging: a potential approach to predict the response to cardiac resynchronization therapy. Int J Cardiovasc Imaging 2009; 25: 677–687.
- 61Tanaka H, Hara H, Saba S, Gorcsan J III. Prediction of response to cardiac resynchronization therapy by speckle tracking echocardiography using different software approaches. J Am Soc Echocardiogr 2009; 22: 677–684.
- 62Tops LF, Delgado V, Bax JJ. The role of speckle tracking strain imaging in cardiac pacing. Echocardiography 2009; 26: 315–323.
- 63Nesser HG, Winter S. Speckle tracking in the evaluation of left ventricular dyssynchrony. Echocardiography 2009; 24: 324–336.
- 64Stefani L, Pedrizzetti G, De Luca A, Mercuri R, Innocenti G, Galanti G. Real-time evaluation of longitudinal peak systolic strain (speckle tracking measurement) in left and right ventricles of athletes. Cardiovasc Ultrasound 2009; 7: 17.
- 65Stefani L, De Luca A, Maffulli N et al. Speckle tracking for left ventricle performance in young athletes with bicuspid aortic valve and mild aortic regurgitation. Eur J Echocardiogr 2009; 10: 527–531.
- 66Nottin S, Doucende G, Schuster I, Tanguy S, Dauzat M, Obert P. Alteration in left ventricular strains and torsional mechanics after ultralong duration exercise in athletes. Circ Cardiovasc Imaging 2009; 2: 323–330.
- 67Richand V, Lafitte S, Reant P, et al. An ultrasound speckle tracking (two-dimensional strain) analysis of myocardial deformation in professional soccer players compared with healthy subjects and hypertrophic cardiomyopathy. Am J Cardiol 2007; 100: 128–132.
- 68Friedberg MK, Slorach C. Relation between left ventricular regional radial function and radial wall motion abnormalities using two-dimensional speckle tracking in children with idiopathic dilated cardiomyopathy. Am J Cardiol 2008; 102: 335–339.
- 69Sengupta PP, Krishnamoorthy VK, Abhayaratna WP, et al. Disparate patterns of left ventricular mechanics differentiate constrictive pericarditis from restrictive cardiomyopathy. JACC Cardiovasc Imaging 2008; 1: 29–38.
- 70van Dalen BM, Caliskan K, Soliman OI, et al. Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and quantitative functional diagnostic criterion? Eur J Heart Fail 2008; 10: 1088–1093.
- 71Baccouche H, Maunz M, Beck T, Fogarassy P, Beyer M. Echocardiographic assessment and monitoring of the clinical course in a patient with Tako-Tsubo cardiomyopathy by a novel 3D-speckle-tracking-strain analysis. Eur J Echocardiogr 2009; 10: 729–731.
- 72Cameli M, Lisi M, Palmerini E, et al. Left ventricular torsion dynamics by speckle tracking echocardiography after cardiac surgery or heart transplantation [abstract]. In: Proceedings of the 2009 EUROECHO Congress; Madrid, Spain. Sophia Antipolis, France: European Society of Cardiology; 2009:801.
- 73Saraiva RM, Demirkol S, Buakhamsri A, et al. Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function. J Am Soc Echocardiogr 2010; 23: 172–180.
- 74Cameli M, Caputo M, Lisi M, et al. Early detection of left atrial dysfunction in patients with hypertension, diabetes, or both by two-dimensional speckle tracking echocardiography [abstract]. In: Proceedings of the 2009 European Society of Cardiology Congress; Barcelona, Spain. Sophia Antipolis, France: European Society of Cardiology; 2009:4470.
- 75Wakami K, Ohte N, Asada K, et al. Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole. J Am Soc Echocardiogr 2009; 22: 847–851.
- 76Cameli M, Lisi M, Mondillo S, et al. Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure. Cardiovasc Ultrasound 2010; 8: 14.
- 77Jurcut R, Wildiers H, Ganame J, D'Hooge J, Paridaens R, Voigt JU. Detection and monitoring of cardiotoxicity: what does modern cardiology offer? Support Care Cancer 2008; 16: 437–445.
- 78Roul G, Cohen C, Lieber A. Anthracycline-induced cardiomyopathy [in French]. Presse Med 2009; 38: 987–994.
- 79Hare JL, Brown JK, Leano R, Jenkins C, Woodward N, Marwick TH. Use of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumab. Am Heart J 2009; 158: 294–301.
- 80Nesser HJ, Mor-Avi V, Gorissen W, et al. Quantification of left ventricular volumes using three-dimensional echocardiographic speckle tracking: comparison with MRI. Eur Heart J 2009; 30: 1565–1573.