PILOCARPINE SEIZURES CAUSE AGE-DEPENDENT IMPAIRMENT IN AUDITORY LOCATION DISCRIMINATION
John C. Neill,
Zhao Liu,
Mohammad Mikati,
Gregory L. Holmes,
Corresponding Author
John C. Neill
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
John Neill is now at Long Island University
Psychology Department, Long Island University, 720 Northern Boulevard, Brookville, New York 11548 (e-mail:[email protected]).Search for more papers by this authorZhao Liu
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
Zhao Liu is now at the University of Florida
Search for more papers by this authorMohammad Mikati
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
Mohammad Mikati is now at American University of Beirut
Search for more papers by this authorGregory L. Holmes
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
Gregory Holmes is now at Dartmouth-Hitchock Medical Center
Search for more papers by this authorJohn C. Neill,
Zhao Liu,
Mohammad Mikati,
Gregory L. Holmes,
Corresponding Author
John C. Neill
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
John Neill is now at Long Island University
Psychology Department, Long Island University, 720 Northern Boulevard, Brookville, New York 11548 (e-mail:[email protected]).Search for more papers by this authorZhao Liu
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
Zhao Liu is now at the University of Florida
Search for more papers by this authorMohammad Mikati
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
Mohammad Mikati is now at American University of Beirut
Search for more papers by this authorGregory L. Holmes
CHILDREN'S HOSPITAL, BOSTON AND HARVARD MEDICAL SCHOOL
Gregory Holmes is now at Dartmouth-Hitchock Medical Center
Search for more papers by this authorAbstract
Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans.
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