To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second-degree burns: A randomized triple-blind clinical trial
Corresponding Author
Mehrdad Abdullahzadeh MSc
Department of Nursing and Midwifery, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Correspondence
Mehrdad Abdullahzadeh, Department of Nursing and Midwifery, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Email: [email protected]
Search for more papers by this authorSaeed Shafiee MSc
Department of Medical-Surgical Nursing, Student Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Search for more papers by this authorCorresponding Author
Mehrdad Abdullahzadeh MSc
Department of Nursing and Midwifery, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Correspondence
Mehrdad Abdullahzadeh, Department of Nursing and Midwifery, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Email: [email protected]
Search for more papers by this authorSaeed Shafiee MSc
Department of Medical-Surgical Nursing, Student Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Search for more papers by this authorFunding information: Isfahan University of Medical Sciences
Abstract
Burn injuries can be associated with the incidence of disability and death, yet their management remains a costly difficult problem. We conducted this clinical trial to evaluate the period of wound healing with sea buckthorn dressings for the second-degree burns and compare the results with 1% silver sulfadiazine (SSD) dressings. This randomized triple-blind clinical trial was conducted in a hospital in Isfahan, Iran. Fifty-five patients suffering second-degree burns were recruited through convenient sampling and randomly divided into two groups and treated with either sea buckthorn cream or 1% SSD. Wound dressings were done until complete wound healing was attained. The process of healing burns was monitored using the Bates-Jensen Wound Assessment Tool; complete healing was determined by using the standard burn healing checklist. It was deduced that the period of healing second-degree burns in the group treated with sea buckthorn cream was shorter than the group treated with 1% SSD (p < 0.001). The results demonstrated the greater clinical efficacy of sea buckthorn cream over 1% SSD for healing second-degree burns. It was concluded that using sea buckthorn dressing by reducing the period of wound healing can shorten the course of treatment of second-degree burns as well as reduce the burden of care in health care services.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
REFERENCES
- 1Hosseini SM, Fekrazad R, Malekzadeh H, Farzadinia P, Hajiani M. Evaluation and comparison of the effect of honey, milk, and combination of honey-milk on experimental induced second-degree burns of Rabit. J Family Med Prim Care. 2020; 9(2): 915-920. https://doi.org/10.4103/jfmpc.jfmpc_801_19.
- 2Aghaei A, Soori H, Mehrabi Y, Ramezankhani A. Factors related to pediatric unintentional burns: the comparison of logistic regression and data mining algorithms. J Inj Violence Res. 2019; 11(4 Suppl. 2):35.
- 3Klifto KM, Dellon AL, Hultman CS. Prevalence and associated predictors for patients developing chronic neuropathic pain following burns. Burns Trauma. 2020; 8:tkaa011. https://doi.org/10.1093/burnst/tkaa011.
- 4Guest JF, Fuller GW, Edwards J. Cohort study evaluating management of burns in the community in clinical practice in the UK: costs and outcomes. BMJ Open. 2020; 10(4):e035345. https://doi.org/10.1136/bmjopen-2019-035345.
- 5Perdanakusuma DS, Hariani L, Nasser NF, Datusanantyo RA. The effect of a single-strain probiotic administration in the treatment of thermal burns patients. Iran J Microbiol. 2019; 11(6): 541.
- 6Rashaan ZM, Krijnen P, Kwa KA, van Baar ME, Breederveld RS, van den Akker-van Marle ME. Long-term quality of life and cost-effectiveness of treatment of partial-thickness burns: a randomized controlled trial comparing enzyme alginogel vs silver sulfadiazine (FLAM study). Wound Repair Regen. 2020; 28(3): 375-384. https://doi.org/10.1111/wrr.12799.
- 7Hissae Yassue-Cordeiro P, Zandonai CH, Pereira Genesi B, et al. Development of chitosan/silver sulfadiazine/zeolite composite films for wound dressing. Pharmaceutics. 2019; 11(10):535. https://doi.org/10.3390/pharmaceutics11100535.
- 8Chartkitcharoen A, Muangman P, Chuntrasakul C, et al. Effectiveness of 1% silver sulfadiazine with zinc versus 1% silver sulfadiazine in burn wound healing. J Med Assoc Thai. 2020; 103(5): 44-50.
- 9Zhang XH, Cui CL, Lee KK, Chen XX, Yu JA, Wu WW. A specially designed medical screen for children suffering from burns: a randomized trial of a distraction-type therapy. Burns. 2020. https://doi.org/10.1016/j.burns.2020.05.018.
- 10Kusu-Orkar TE, Islam U, Hall B, Araia E, Allorto N. The use of a non-medicated dressing for superficial-partial thickness burns in children: a case series and review. Scars Burn Heal. 2019; 5:2059513119896954. https://doi.org/10.1177/2059513119896954.
10.1177/2059513119896954 Google Scholar
- 11Balkrishna A, Sakat SS, Joshi K, et al. Cytokines driven anti-inflammatory and anti-psoriasis like efficacies of nutraceutical sea buckthorn (Hippophae rhamnoides) oil. Front Pharmacol. 2019; 10:1186. https://doi.org/10.3389/fphar.2019.01186.
- 12Jiang SB, Lu YS, Zhang YH, et al. A retrospective study of a Chinese traditional medicine YIKEER in the treatment of verruca patients in Liaoning District. Evid Based Complement Alternat Med. 2019; 2019:9896148. https://doi.org/10.1155/2019/9896148.
- 13Niimi Y, Perez-Bello D, Fukuda S, et al. 368 Omega-7 accelerates burn wound healing via increase telomerase activity. J Burn Care Res. 2018; 39(Suppl. 1):S132. https://doi.org/10.1093/jbcr/iry006.290.
- 14Sarvestani FS, Mehrabani D, Tanideh N, et al. Investigation of eucalyptus essence 1% and its mixture with licorice gel 10% on the infected third-degree burn wound in the rat model. Comp Clin Pathol. 2019; 28: 403-409. https://doi.org/10.1007/s00580-018-2732-3.
- 15Tudor C, Bohn T, Iddir M, et al. Sea buckthorn oil as a valuable source of bioaccessible xanthophylls. Nutrients. 2020; 12(1): 76.
- 16Solà Marsiñach M, Cuenca AP. The impact of sea buckthorn oil fatty acids on human health. Lipids Health Dis. 2019; 18(1):145. https://doi.org/10.1186/s12944-019-1065-9.
- 17Kim J, Lee CM. Wound healing potential of a polyvinyl alcohol-blended pectin hydrogel containing Hippophae rahmnoides L. extract in a rat model. Int J Biol Macromol. 2017; 99: 586-593. https://doi.org/10.1016/j.ijbiomac.2017.03.014.
- 18Niimi Y, Pérez-Bello D, Ihara K, et al. Omega-7 oil increases telomerase activity and accelerates the healing of grafted burn and donor site wounds. Sci Rep. 2021; 11:975. https://doi.org/10.1038/s41598-020-79597-0.
- 19Hou DD, Di ZH, Qi RQ, et al. Sea buckthorn (Hippophaë rhamnoides L.) oil improves atopic dermatitis-like skin lesions via inhibition of NF-κB and STAT1 activation. Skin Pharmacol Physiol. 2017; 30(5): 268-276.
- 20Kumari DP. Potential health benefits of sea buckthorn oil—a review. Agric Rev. 2017; 38(3): 233-237. https://doi.org/10.18805/ag.v38i03.8984.
- 21Jalilimanesh M, Azhdari M, Mirjalili A, Mozaffari MA, Hekmatimoghaddam S. The comparison of clinical and histopathological effects of topical psyllium (Plantago ovata) powder and silver sulfadiazine on second-degree burn wound healing in rats. World J Plast Surg. 2021; 10(1): 96-103. http://wjps.ir/article-1-728-en.html.
- 22Jahani S, Ashrafizadeh H, Babai K, Siahpoosh A, Cheraghian B. Effect of ointment-based egg white on the healing of the second-degree wound in burn patients: a triple-blind randomized clinical trial study. Avicenna J Phytomed. 2019; 9(3): 260-270.
- 23Chen B, Yue X, Zhang R, Song H. Statistical analysis of factors affecting re-operative times in pediatric patients with scar deformity after deep second-degree burn injury. Int Wound J. 2018; 15: 565-570. https://doi.org/10.1111/iwj.12899.
- 24Sones W, Julious SA, Rothwell JC, et al. Correction to: choosing the target difference and undertaking and reporting the sample size calculation for a randomized controlled trial – the development of the DELTA2 guidance. Trials. 2019; 20(1):602. https://doi.org/10.1186/s13063-019-3809-2.
- 25Murari A, Singh KN. Lund and Browder chart-modified versus original: a comparative study. Acute Crit Care. 2019; 34(4): 276-281. https://doi.org/10.4266/acc.2019.00647.
- 26Li S, Mohamedi AH, Senkowsky J, Nair A, Tang L. Imaging in chronic wound diagnostics. Adv Wound Care (New Rochelle). 2020; 9(5): 245-263. https://doi.org/10.1089/wound.2019.0967.
- 27Shukla U, Kumar A, Anushapreethi S, Singh SP. Evaluation of the efficacy of hyperbaric oxygen therapy in the management of diabetic ulcers using Bates-Jensen wound assessment tool. Anesth Essays Res. 2020; 14(2): 335.
- 28Dasari V, Dhaniwala NK, Khan SM, Kumbhare VU. Management of traumatic wounds of hand and foot by various modalities: a comparative analysis. Int J Cur Res Rev. 2021; 13(2): 136. https://doi.org/10.31782/IJCRR.2021.13235.
10.31782/IJCRR.2021.13235 Google Scholar
- 29Garbuio DC, Zamarioli CM, Silva NCM, Oliveira-Kumakura ARS, Carvalho EC. Assessment tools for the healing of wounds: an integrative review. Rev Eletr Enf. 2018; 20:v20a40. https://doi.org/10.5216/ree.v20.49425.
- 30Karahan A, AAbbasoğlu A, Işık SA, et al. Factors affecting wound healing in individuals with pressure ulcers: a retrospective study. Ostomy Wound Manage. 2018; 64(2): 32-39.
- 31Hosseini SA, Heidari M, Shahbazi S, Daryabeigi R, Ali Sheikhi R, Heidari K. Comparison of second-degree burns healing time in two methods of dressing with fundermol herbal ointment and 1% silver sulfadiazine ointment. Med J Tabriz Univ Med Sci. 2012; 33(6): 51-55.
- 32Ebrahimi M, Dayabeigi R, Shahtalebi MA, Abedini F. Wound dressing of second-degree burn by chamomile cream and silver sulfadiazine cream; the effects on wound healing duration; a triple-blind RCT. J Med Plants. 2020; 19(75): 305-311.
10.29252/jmp.19.75.305 Google Scholar
- 33Singh IP, Ahmad F, Gore DD, et al. Therapeutic potential of seabuckthorn: a patent review (2000-2018). Expert Opin Ther Pat. 2019; 29(9): 733-744. https://doi.org/10.1080/13543776.2019.1648434.
- 34Koskovac M, Cupara S, Kipic M, et al. Sea buckthorn oil—a valuable source for cosmeceuticals. Cosmetics. 2017; 4(4): 40-190. https://doi.org/10.1016/j.jep.2017.11.022.
10.3390/cosmetics4040040 Google Scholar
- 35Lachapelle JM, Maibach HI. Patch Testing and Prick Testing. Cham: Springer International; 2020. https://doi.org/10.1007/978-3-030-27099-5_4.
10.1007/978-3-030-27099-5 Google Scholar
- 36Resch A, Staud C, Radtke C. Nanocellulose-based wound dressing for conservative wound management in children with second-degree burns. Int Wound J. 2021. https://doi.org/10.1111/iwj.13548.
- 37Yoshino Y, Hashimoto A, Ikegami R, et al. Wound, pressure ulcer and burn guidelines – 6: guidelines for the management of burns, second edition. J Dermatol. 2020; 47: 1207-1235. https://doi.org/10.1111/1346-8138.15335.
- 38Haddadi M, Jaghouri E, Robat Sarpooshi H. The effect of topical vitamin C solution on granulation tissue formation in burn wounds. J Cosmet Dermatol. 2019; 10(3): 161-169. http://jdc.tums.ac.ir/article-1-5406-en.html.
- 39Singh A, Bhatnagar A. Management of superficial partial thickness burn with collagen sheet dressing compared with paraffin gauze and silver sulfadiazine. Ann Burns Fire Disasters. 2020; 33(3): 233-238.
- 40Yao Q, Jia T, Qiao W, Gu H, Kaku K. Unsaturated fatty acid-enriched extract from Hippophae rhamnoides seed reduces skin dryness through up-regulating aquaporins 3 and hyaluronan synthetases 2 expressions. J Cosmet Dermatol. 2020; 20: 321-329. https://doi.org/10.1111/jocd.13482.
- 41Kaur T, Kapoor DN. Development and evaluation of sea buckthorn (Hippophae rhamnoides L.) seed oil nanoemulsion gel for wound healing. Phcog Mag 2018; 14: 647–58.Available from: http://www.phcog.com/text.asp?2018/14/58/647/245913
- 42Miastkowska M, Kulawik-Pióro A, Szczurek M. Nanoemulsion gel formulation optimization for burn wounds: analysis of rheological and sensory properties. Processes. 2020; 8(11): 1416.
- 43Goudarzi R, Nasab ME, Saffari PM, Zamanian G, Park CD, Partoazar A. Evaluation of ROCEN on burn wound healing and thermal pain: transforming growth factor-β1 activation. Int J Low Extrem Wounds. 2020;153473462091532. https://doi.org/10.1177/1534734620915327.
- 44Chandra S, Zafar R, Dwivedi P, Shinde LP, Prita B. Pharmacological and nutritional importance of sea buckthorn (Hippophae). Pharma Innov. 2018; 7(5): 258.
- 45Tkacz K, Wojdyło A, Turkiewicz IP, Bobak Ł, Nowicka P. Anti-oxidant and anti-enzymatic activities of sea buckthorn (Hippophaë rhamnoides L.) fruits modulated by chemical components. Antioxidants. 2019 Dec; 8(12):618. https://doi.org/10.3390/antiox8120618.
- 46Ji M, Gong X, Li X, Wang C, Li M. Advanced research on the antioxidant activity and mechanism of polyphenols from Hippophae species—a review. Molecules. 2020 Jan; 25(4):917. https://doi.org/10.3390/molecules25040917.
- 47Ion VA, Parvulescu OC, Velcea D, Popa O, Ahmadi M. Physico-chemical parameters and antioxidant activity of Romanian sea buckthorn berries. Rev Chim. 2019; 70: 4187-4193.
- 48Gęgotek A, Jastrząb A, Jarocka-Karpowicz I, Muszyńska M, Skrzydlewska E. The effect of sea buckthorn (Hippophae rhamnoides L.) seed oil on UV-induced changes in lipid metabolism of human skin cells. Antioxidants (Basel). 2018; 7(9):110. https://doi.org/10.3390/antiox7090110.
- 49Niimi Y, Fukuda S, Alharbi S, Prough DS, Enkhbaatar P. Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research. Regen Ther. 2020; 14: 341-343. https://doi.org/10.1016/j.reth.2020.04.007.
- 50Upadhyay NK, Kumar R, Siddiqui MS, Gupta A. Mechanism of wound-healing activity of Hippophae rhamnoides L. leaf extract in experimental burns. Evid Based Complement Alternat Med. 2011; 2011: 659705.
- 51Pundir S, Garg P, Dviwedi A, et al. Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: a review. J Ethnopharmacol. 2020; 2:113434. https://doi.org/10.1016/j.jep.2020.113434.
- 52Ivanišová E, Blašková M, Terentjeva M, Grygorieva O, Vergun O, Brindza J. Biological properties of sea buckthorn (Hippophae rhamnoides L.) derived products. Acta Sci Pol Technol Aliment. 2020; 19(2): 195-205. https://doi.org/10.17306/J.AFS.2020.0809.