Eluates from DAT-positive patients with or without hemolysis after high-dose IVIG yield predominantly IgG isoagglutinins of IgG2 subclass
Gisella Puga Yung PhD
Division of Immunology and Allergy, University Hospitals and Medical Facility, Geneva, Switzerland
Search for more papers by this authorJoerg D. Seebach MD, PhD
Division of Immunology and Allergy, University Hospitals and Medical Facility, Geneva, Switzerland
Search for more papers by this authorNatasha Baerenzung BS
Division of Immunology and Allergy, University Hospitals and Medical Facility, Geneva, Switzerland
Search for more papers by this authorJacob Pendergrast MD
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorChristine Cserti-Gazdewich MD
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorDonald R. Branch PhD
Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Centre for Innovation, Canadian Blood Services, Toronto, Ontario, Canada
Search for more papers by this authorGisella Puga Yung PhD
Division of Immunology and Allergy, University Hospitals and Medical Facility, Geneva, Switzerland
Search for more papers by this authorJoerg D. Seebach MD, PhD
Division of Immunology and Allergy, University Hospitals and Medical Facility, Geneva, Switzerland
Search for more papers by this authorNatasha Baerenzung BS
Division of Immunology and Allergy, University Hospitals and Medical Facility, Geneva, Switzerland
Search for more papers by this authorJacob Pendergrast MD
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorChristine Cserti-Gazdewich MD
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorDonald R. Branch PhD
Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Centre for Innovation, Canadian Blood Services, Toronto, Ontario, Canada
Search for more papers by this authorCONFLICT OF INTEREST
The authors have disclosed no conflicts of interest.
REFERENCES
- 1Pendergrast J, Binnington B, Tong TN, et al. Incidence and risk factors for IVIG-mediated hemolysis. Blood 2017; 130: 2398.
- 2Pendergrast J, Willie-Ramharack K, Sampson L, et al. The role of inflammation in intravenous immune globulin-mediated hemolysis. Transfusion 2015; 55: S65-73.
- 3Branch DR, Hellberg A, Bruggeman CW, et al. ABO zygosity, but not secretor or Fc receptor status, is a significant risk factor for IVIG-associated hemolysis. Blood 2018; 131: 830-5.
- 4Stussi G, Huggel K, Lutz HU, et al. Isotype-specific detection of ABO blood group antibodies using a novel flow cytometric method. Br J Haematol 2005; 130: 954-63.
- 5Devine D. Important information regarding IVIG-associated hemolysis (customer letter 2009-02). [cited 2009 Feb 19]. https://blood.ca/sites/default/files/CL_2009-02.pdf.
- 6Valenzuela NM, Schaub S. The biology of IgG subclasses and their clinical relevance to transplantation. Transplantation 2018; 102(1S Suppl 1): S7-13.
- 7Branch DR. Anti-A and anti-B: what are they and where do they come from? Transfusion 2015; 55(Suppl 2): S74-9.
- 8Bruhns P, Iannascoli B, England P, et al. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 2009; 113: 3716-25.
- 9Parren PW, Warmerdam PA, Boeije LC, et al. On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2. J Clin Invest 1992; 90: 1537-46.