Use of next-generation sequencing to detect polymorphism of 11 HLA allele loci in the Chinese Han population and variance from other common and well-documented lists
Funding information: National Natural Science Foundation of China, Grant/Award Number: 82070180; Jiangsu Provincial Key Research and Development Program, Grant/Award Number: BE2019656
Abstract
The focus of this study was to analyze polymorphisms in the HLA gene at 11 loci in 4845 Chinese Han populations using next-generation sequencing methods, and to compare common and well-documented (CWD) allelic differences between China and other CWD lists. A total of 44 DPB1 alleles, 13 DPA1 alleles, 20 DQA1 alleles and 19 DRB3/4/5 alleles were detected in this study. About 20%–50% of the CWD alleles in China differ from the American Society for Histocompatibility and Immunogenetics and European Federation for Immunogenetics (EFI) data. The revised list of HLA-CWD alleles in the Han population will provide additional data for the update of the IMGT/HLA database and contribute to a better understanding of hematopoietic stem cell transplantation and organ transplantation.
CONFLICT OF INTEREST
This work was supported by the National Natural Science Foundation of China (Grant No. 82070180), and Jiangsu Provincial Key Research and Development Program (Grant No. BE2019656). We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.
Open Research
DATA AVAILABILITY STATEMENT
The data that supports the findings of this study are available in the supplementary material of this article
