Volume 55, Issue 3 e70031
ORIGINAL ARTICLE

Unraveling the Bidirectional Associations of Psychotic-Like Experiences With Depressive Symptoms and Suicidal Ideation Among Adolescents

Dongfang Wang

Dongfang Wang

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Contribution: Conceptualization (equal), Data curation (equal), Writing - original draft (equal)

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Brendan Ross

Brendan Ross

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Contribution: Conceptualization (equal), Writing - review & editing (equal)

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Meng Sun

Meng Sun

Department of Social Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China

Contribution: Conceptualization (equal), Writing - review & editing (equal)

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Huolian Li

Huolian Li

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Contribution: ​Investigation (equal), Writing - review & editing (equal)

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Xiangting Zhang

Xiangting Zhang

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Contribution: ​Investigation (equal), Writing - review & editing (equal)

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Xuan Wang

Xuan Wang

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Contribution: ​Investigation (equal), Writing - review & editing (equal)

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Yang Qiu

Yang Qiu

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Contribution: ​Investigation (equal), Writing - review & editing (equal)

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Zijuan Ma

Corresponding Author

Zijuan Ma

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Correspondence:

Zijuan Ma ([email protected])

Fang Fan ([email protected])

Contribution: Conceptualization (equal), Data curation (equal), Supervision (equal), Writing - review & editing (equal)

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Fang Fan

Corresponding Author

Fang Fan

School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China

Correspondence:

Zijuan Ma ([email protected])

Fang Fan ([email protected])

Contribution: Conceptualization (equal), Data curation (equal), Funding acquisition (equal), Supervision (equal), Writing - review & editing (equal)

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First published: 25 June 2025

Funding: This study was funded by the Philosophy and Social Science Planning Project of Guangdong Province (GD25YXL16), Fundamental and Applied Basic Research Program in Guangzhou (2025A04J3416; 2024A1515220104), Science and Technology Program of Guangzhou (2024A04J10000, 2024A03J0223), Psychological services and counseling bases for the Happy Guangzhou project, which received funding from the Guangzhou Government, and Striving for the First-Class, Improving Weak Links and Highlighting Features (SIH) Key Discipline for Psychology in South China Normal University.

ABSTRACT

Background

Previous literature suggests that adolescent psychotic-like experiences (PLEs) are associated with depressive symptoms and suicidal ideation. This study aimed to explore these prospective relationships between PLEs, depressive symptoms, and suicidal ideation among adolescents.

Methods

A large-scale web-based survey was conducted using repeated measures at three time points: from 21 April to 12 May 2021 (T1), from 17 to 26 December 2021 (T2), and from 17 May to 6 June 2022 (T3). A total of 17,722 adolescents were assessed at both T1 and T2, and 15,694 adolescents also provided complete responses at both T1 and T3. Self-reported scales were used to assess PLEs and depressive symptoms, and suicidal ideation was assessed.

Results

PLEs at baseline were significantly associated with increased odds of depressive symptoms and suicidal ideation at both follow-up intervals after adjusting for covariates (all p < 0.001). Moreover, baseline depressive symptoms and suicidal ideation were significantly associated with increased likelihoods of subsequent PLEs (all p < 0.001).

Conclusions

This study underscores bidirectional prospective associations between PLEs, depressive symptoms, and suicidal ideation among adolescents, and its findings underscore the critical educational and clinical importance of screening for PLEs while treating depressive symptoms and suicidal ideation.

Conflicts of Interest

The authors declare no conflicts of interest.

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