Nontuberculous mycobacteria in diffuse panbronchiolitis
Corresponding Author
Takahiro Tsuji
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Correspondence: Takahiro Tsuji, Department of Respiratory Medicine, Tenri Hospital, 200 Mishima-cho, Tenri City, Nara 632-8552, Japan. Email: [email protected]Search for more papers by this authorEisaku Tanaka
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorIkkoh Yasuda
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorYoshinari Nakatsuka
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorYusuke Kaji
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorTakehiro Yasuda
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorSeishu Hashimoto
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorMoon Hee Hwang
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorTakashi Hajiro
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorYoshio Taguchi
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorCorresponding Author
Takahiro Tsuji
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Correspondence: Takahiro Tsuji, Department of Respiratory Medicine, Tenri Hospital, 200 Mishima-cho, Tenri City, Nara 632-8552, Japan. Email: [email protected]Search for more papers by this authorEisaku Tanaka
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorIkkoh Yasuda
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorYoshinari Nakatsuka
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorYusuke Kaji
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorTakehiro Yasuda
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorSeishu Hashimoto
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorMoon Hee Hwang
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorTakashi Hajiro
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorYoshio Taguchi
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan
Search for more papers by this authorAbstract
Background and objective
Nontuberculous mycobacterial (NTM) lung disease secondary to cystic fibrosis (CF) has been reported, but there is limited data about NTM prevalence in non-CF bronchiectasis. We retrospectively investigated the prevalence of NTM associated with diffuse panbronchiolitis (DPB), a disorder also characterized by reduced mucociliary clearance with bronchiectasis.
Methods
We reviewed mycobacterial cultures, patient characteristics and computed tomography findings of 33 patients with DPB between January 2000 and December 2012. Prevalence was based on at least one positive NTM culture.
Results
Mean patient age was 51.5 years. During a mean 162.8-month follow-up, the prevalence of NTM in sputum was 21.2% (seven patients). Of the seven positive patients, six had Mycobacterium avium complex, one had M. kansasii and M. chelonae co-cultured with M. avium complex. Three patients were positive twice, and two had positive smears. The mean time from DPB diagnosis to the first positive result was 194.6 months. NTM-positive patients tended to have lower forced expiratory volume in 1 s (% predicted) than NTM-negative patients (50.0% vs 77.3%, P = 0.03), but there were no radiological or clinical differences between the two groups.
Conclusions
Our observations suggest that NTM is found more often in DPB. Defects of mucociliary clearance may predispose individuals to NTM infection.
Supporting Information
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| resp12412-sup-0001-si.docx117.1 KB |
Figure S1 Trends in forced expiratory volume in 1 s (FEV1) % predicted in the nontuberculous mycobacteria (NTM)-positive patients. Six of seven NTM-positive patients were presented. One patient had received pulmonary function test once (data not shown). Three patients received pulmonary function test both before and after NTM-positive result. FEV1 was improved in two patients, but deteriorated in one patient. Figure S2 Comparison of nontuberculous mycobacteria (NTM) prevalence between patients with diffuse panbronchiolitis (DPB) and chronic obstructive pulmonary disease (COPD). (a) NTM prevalence of total patients who regularly visit the institute. (b) NTM prevalence of patient who received acid fast bacterium (AFB) culture test. P value was calculated using Fisher's exact test as 2 × 2 contingency table. Definition of abbreviations: ATS: American Thoracic Society; IDSA: Infectious Diseases Society of America. Table S1 Microbiological characteristics in DPB patients with or without NTM. Table S2 Respiratory symptoms in DPB patients with or without NTM. Table S3 Radiological progression in DPB patients with or without NTM. Table S4 NTM prevalence in COPD patients. Appendix S1 Methods. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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