Oral Mucositis and Nutritional Status in Children Who Underwent Hematopoietic Cell Transplantation: A Comparison Between Nonmalignant and Malignant Primary Diseases
Fabíola Germano de Castro
Hospital Israelita Albert Einstein, São Paulo, Brazil
School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorFernanda de Paula Eduardo
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorLeticia Mello Bezinelli
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorNelson Hamerschlak
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorGabriele Zamperlini Netto
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorJuliana Folloni Fernandes
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorCorresponding Author
Luciana Corrêa
School of Dentistry, University of São Paulo, São Paulo, Brazil
Correspondence:
Luciana Corrêa ([email protected])
Search for more papers by this authorFabíola Germano de Castro
Hospital Israelita Albert Einstein, São Paulo, Brazil
School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorFernanda de Paula Eduardo
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorLeticia Mello Bezinelli
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorNelson Hamerschlak
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorGabriele Zamperlini Netto
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorJuliana Folloni Fernandes
Hospital Israelita Albert Einstein, São Paulo, Brazil
Search for more papers by this authorCorresponding Author
Luciana Corrêa
School of Dentistry, University of São Paulo, São Paulo, Brazil
Correspondence:
Luciana Corrêa ([email protected])
Search for more papers by this authorABSTRACT
Background
There is a lack of studies analyzing the association between oral mucositis (OM) and nutritional imbalance in children during hematopoietic stem cell transplantation (HSCT). The aim of this study was to compare the risk factors for OM and nutritional imbalance during HSCT in pediatric patients with nonmalignant diseases (NMD) and malignant diseases (MD).
Methods
Data on age, sex, primary disease, transplantation type, conditioning regimen, GVHD prophylaxis, gastrointestinal toxicity, OM, percent body weight loss or gain, nutritional repositioning, and overall survival (OS) were retrospectively collected from the 132 medical records. The data were then compared between patients with NMD (n = 70) and MD (n = 62).
Results
OM had a similar severity between the groups. The primary risk factor for OM in the NMD group was the conditioning regimen with busulfan, while in the MD group it was GVHD prophylaxis with cyclosporin and methotrexate. OM did not have an impact on body weight loss or gain in any of the groups. In the NMD, body weight gain due to fluid overload was more pronounced and associated with a lower age range. OS was similar between the groups and was not affected by OM.
Conclusions
OM pattern was similar in pediatric patients with or without MD, but the factors that determined these oral lesions were different. There were disparities in body weight changes between the two groups, and these changes were not associated to OM.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| petr14820-sup-0001-TableS1.docxWord 2007 document , 18.8 KB |
TABLE S1. Univariate analysis* using variables related to the patient and transplantation with possible significant association with oral mucositis and body weight change. TABLE S2. Univariate analysis* using discrete and continuous variables related to oral mucositis and body weight change with possible significant association with nutritional replacement. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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